Gene Report

Basic Information

Approved Symbol	RAPGEF6
Approved Name	Rap guanine nucleotide exchange factor (GEF) 6
Previous Symbol	PDZGEF2
Previous Name	"PDZ domain containing guanine nucleotide exchange factor (GEF) 2"
Symbol Alias	RA-GEF-2, PDZ-GEF2
Location	5q31.1
Position	chr5:130970724-130970921 (-)
External Links	Entrez Gene: 51735 Ensembl: ENSG00000158987 UCSC: uc010jdi.2 HGNC ID: 20655
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RAPGEF6 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
RAPGEF6	Chu TT, 2009	Patients and nomal controls		Down regulation, fold change([MD] vs [C]) 2.022933 Down regulation, fold change([MD] vs [C]) 2.022933

Positive relationships between RAPGEF6 and other components at different levels (count: 0)

Positive relationship network of RAPGEF6 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RAPGEF6 and MDD (count: 0)

Negative relationships between RAPGEF6 and other components at different levels (count: 0)

RAPGEF6 related SNPs in MK4MDD (count: 0)

RAPGEF6 related proteins in MK4MDD (count: 0)

RAPGEF6 related GO terms (count: 15)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005886	plasma membrane	cellular component	IDA[11524421]
GO:0030139	endocytic vesicle	cellular component	IDA[22797597]
GO:0030033	microvillus assembly	biological process	IGI[22797597]
GO:0005515	protein binding	molecular function	IPI[12095257\|14698303\|17240990]
GO:0017016	Ras GTPase binding	molecular function	IDA[11524421]
GO:0043087	regulation of GTPase activity	biological process	NAS[11524421]
GO:0005829	cytosol	cellular component	IDA[22797597]
GO:0030742	GTP-dependent protein binding	molecular function	IDA[11524421]
GO:0090557	establishment of endothelial intestinal barrier	biological process	IMP[23885123]
GO:0043547	positive regulation of GTPase activity	biological process	IMP[22797597]
GO:0016324	apical plasma membrane	cellular component	IDA[22797597]
GO:0072659	protein localization to plasma membrane	biological process	IMP[22797597]
GO:0007265	Ras protein signal transduction	biological process	NAS[11524421]
GO:0005085	guanyl-nucleotide exchange factor activity	molecular function	IDA[11524421]
GO:0070300	phosphatidic acid binding	molecular function	IDA[22797597]

RAPGEF6 related KEGG pathways (count: 0)

RAPGEF6 related BioCarta pathways (count: 0)

RAPGEF6 related Reactome pathways (count: 0)

RAPGEF6 related interactors from protein-protein interaction data in HPRD (count: 6)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
RAPGEF6	RAP2A	No	in vitro;in vivo	11524421 , 12581858
RAPGEF6	MRAS	No	in vitro;in vivo	11524421
RAPGEF6	PTPN13	No	in vitro;yeast 2-hybrid	12095257
RAPGEF6	ABCA1	No	in vitro	16192288
RAPGEF6	YWHAG	No	in vivo	15324660
RAPGEF6	RAP1A	No	in vitro;in vivo	11524421 , 12581858

Gene Report

Gene mapped GO terms