Gene Report

Basic Information

Approved Symbol	GMIP
Approved Name	GEM interacting protein
Symbol Alias	ARHGAP46
Location	19p13.11
Position	chr19:19740285-19754455 (-)
External Links	Entrez Gene: 51291 Ensembl: ENSG00000089639 UCSC: uc002nnd.3 HGNC ID: 24852
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; SNP mapped

Positive relationships between GMIP and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Gem interacting protein, GMIP	Tadokoro, 2005	patients and normal controls	P-value=0.039, odds ratio 1.66, 95% CI 1.05-2.69	We found a significant association with MDD for one single n...... We found a significant association with MDD for one single nucleotide polymorphism (SNP) (-525G/A) located on the 5'-upstream region of the GMIP gene (p=0.039, odds ratio 1.66, 95% CI 1.05-2.69) and stronger evidence for association in a multimarker haplotype analysis (p=0.004). In the MDD patients, was significantly decreased compared with the -525G allele in transient transfection experiments using three types of cell lines More...

Positive relationships between GMIP and other components at different levels (count: 0)

Positive relationship network of GMIP in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GMIP and MDD (count: 0)

Negative relationships between GMIP and other components at different levels (count: 0)

GMIP related SNPs in MK4MDD (count: 4)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs880090	chr19:19740729(Forward)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant	1(1/0)
rs2043293	chr19:19751456(Forward)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant	1(1/0)
rs3794996	chr19:19754942(Forward)	downstream_gene_variant; upstream_gene_variant	1(1/0)
rs2304129	chr19:19746214(Forward)	downstream_gene_variant; intron_variant; nc_transcript_variant	1(1/0)

GMIP related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
GEM-interacting protein	Q9P107	0(0/0)	Gene mapped

GMIP related GO terms (count: 10)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0046872	metal ion binding	molecular function	IEA
GO:0005622	intracellular	cellular component	IC[12093360]
GO:0032321	positive regulation of Rho GTPase activity	biological process	IDA[12093360]
GO:0035556	intracellular signal transduction	biological process	IDA[12093360]
GO:0007264	small GTPase mediated signal transduction	biological process	TAS
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	TAS
GO:0005515	protein binding	molecular function	IPI[12093360]
GO:0005100	Rho GTPase activator activity	molecular function	IDA[12093360]
GO:0005829	cytosol	cellular component	TAS
GO:0034259	negative regulation of Rho GTPase activity	biological process	IDA[12093360]

GMIP related KEGG pathways (count: 0)

GMIP related BioCarta pathways (count: 0)

GMIP related Reactome pathways (count: 1)

Gene mapped Reactome pathways
ID	Name	Description
REACT_11051	rho gtpase_cycle	The cycling of Rho GTPases is tightly controlled by three cl...... The cycling of Rho GTPases is tightly controlled by three classes of protein. These are. More...

GMIP related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GMIP	RHOA	Yes	in vitro;in vivo	12093360
GMIP	GEM	No	in vitro;in vivo	12093360

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways