Gene Report

Basic Information

Approved Symbol	AANAT
Approved Name	aralkylamine N-acetyltransferase
Previous Name	arylalkylamine N-acetyltransferase
Symbol Alias	SNAT
Name Alias	serotonin N-acetyltransferase
Location	17q25
Position	chr17:74449433-74466199 (+)
External Links	Entrez Gene: 15 Ensembl: ENSG00000129673 UCSC: uc002jro.3 HGNC ID: 19
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; SNP mapped

Positive relationships between AANAT and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
AANAT	Soria, 2010	patients and normal controls	P-value<0.01	Common variants (MAF > 2%) were included in a case-control a...... Common variants (MAF > 2%) were included in a case-control association analysis that showed significant association after multiple testing correction of two SNPs located in the promoter region of AANAT with MD: rs3760138 (P = 0.00006) and rs4238989 (P = 0.005) More...

Positive relationships between AANAT and other components at different levels (count: 0)

Positive relationship network of AANAT in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between AANAT and MDD (count: 0)

Negative relationships between AANAT and other components at different levels (count: 0)

AANAT related SNPs in MK4MDD (count: 2)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs4238989	chr17:74463388(Forward)	downstream_gene_variant; intron_variant; upstream_gene_variant	1(1/0)
rs3760138	chr17:74463109(Forward)	downstream_gene_variant; intron_variant; upstream_gene_variant	1(1/0)

AANAT related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Serotonin N-acetyltransferase	Q16613	0(0/0)	Gene mapped

AANAT related GO terms (count: 10)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0004059	aralkylamine N-acetyltransferase activity	molecular function	IDA[11313340]; NAS[8661026]
GO:0071320	cellular response to cAMP	biological process	IDA[11313340]
GO:0046219	indolalkylamine biosynthetic process	biological process	TAS
GO:0006474	N-terminal protein amino acid acetylation	biological process	IDA[11313340]
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0007623	circadian rhythm	biological process	IMP[12736803]; NAS[8661026]
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS
GO:0005829	cytosol	cellular component	TAS
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[11313340]
GO:0030187	melatonin biosynthetic process	biological process	IDA[11313340]; IEA; NAS[8661026]

AANAT related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00380	tryptophan metabolism	Tryptophan metabolism

AANAT related BioCarta pathways (count: 0)

AANAT related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15513	amine derived_hormones	Catecholamines and thyroxine are synthesized from tyrosine, ...... Catecholamines and thyroxine are synthesized from tyrosine, and serotonin and melatonin from tryptophan. More...
REACT_15314	hormone biosynthesis	Hormones are chemicals released in very small quantities by ...... Hormones are chemicals released in very small quantities by cells that affect cellular metabolism in other parts of the body. They can also act as chemical messengers that transport signals from one cell to another. All multicellular organisms produce hormones; these are often transported in the blood. Cells respond to a hormone when they express a specific receptor for that hormone. The hormone binds to the receptor, resulting in the activation of a signal transduction mechanism that ultimately leads to cell type-specific responses. The events annotated here describe the biosynthesis of many types of hormones. More...

AANAT related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
AANAT	F2	No	in vitro	11427721
AANAT	PRKACA	No	in vitro	11336675
AANAT	YWHAZ	No	in vitro;in vivo	11336675 , 11427721

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways