Gene Report

Basic Information

Approved Symbol	AANAT
Approved Name	aralkylamine N-acetyltransferase
Previous Name	"arylalkylamine N-acetyltransferase"
Symbol Alias	SNAT
Name Alias	"serotonin N-acetyltransferase"
Location	17q25.1
Position	chr17:74466053-74466199 (+)
External Links	Entrez Gene: 15 Ensembl: ENSG00000129673 UCSC: uc002jro.3 HGNC ID: 19
No. of Studies (Positive/Negative)	2(1/1)
Type	Literature-origin

Positive relationships between AANAT and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
AANAT	Soria, 2010	patients and normal controls	P-value<0.01	Common variants (MAF > 2%) were included in a case-control a...... Common variants (MAF > 2%) were included in a case-control association analysis that showed significant association after multiple testing correction of two SNPs located in the promoter region of AANAT with MD: rs3760138 (P = 0.00006) and rs4238989 (P = 0.005) More...

Positive relationships between AANAT and other components at different levels (count: 0)

Positive relationship network of AANAT in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between AANAT and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
AANAT	Byrne EM, 2014	Patients and nomal controls	P-Values=0.24	These results show that while there are several circadian ge...... These results show that while there are several circadian genes that harbor SNPs with nominally significant P-values, there are no associations beyond what would be expected after controlling for the number of SNPs in each gene. The gene-based test not only controls for the number of SNPs, but also combines evidence from multiple SNPs after controlling for the linkage disequilibrium between them More...

Negative relationships between AANAT and other components at different levels (count: 0)

AANAT related SNPs in MK4MDD (count: 0)

AANAT related proteins in MK4MDD (count: 0)

AANAT related GO terms (count: 21)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0034097	response to cytokine	biological process	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0007623	circadian rhythm	biological process	IMP[12736803]; NAS[8661026]
GO:0071320	cellular response to cAMP	biological process	IDA[11313340]
GO:0032868	response to insulin	biological process	IEA
GO:0004060	arylamine N-acetyltransferase activity	molecular function	IEA
GO:0046219	indolalkylamine biosynthetic process	biological process	TAS
GO:0010043	response to zinc ion	biological process	IEA
GO:0051412	response to corticosterone	biological process	IEA
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS
GO:0030187	melatonin biosynthetic process	biological process	IDA[11313340]; IEA; NAS[8661026]
GO:0046688	response to copper ion	biological process	IEA
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0009648	photoperiodism	biological process	IEA
GO:0004059	aralkylamine N-acetyltransferase activity	molecular function	IDA[11313340]; NAS[8661026]
GO:0051592	response to calcium ion	biological process	IEA
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[11313340]
GO:0034695	response to prostaglandin E	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[25416956]
GO:0006474	N-terminal protein amino acid acetylation	biological process	IDA[11313340]
GO:0071889	14-3-3 protein binding	molecular function	IEA

AANAT related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00380	tryptophan metabolism	Tryptophan metabolism

AANAT related BioCarta pathways (count: 0)

AANAT related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15314	hormone biosynthesis	Hormones are chemicals released in very small quantities by ...... Hormones are chemicals released in very small quantities by cells that affect cellular metabolism in other parts of the body. They can also act as chemical messengers that transport signals from one cell to another. All multicellular organisms produce hormones; these are often transported in the blood. Cells respond to a hormone when they express a specific receptor for that hormone. The hormone binds to the receptor, resulting in the activation of a signal transduction mechanism that ultimately leads to cell type-specific responses. The events annotated here describe the biosynthesis of many types of hormones. More...
REACT_15513	amine derived_hormones	Catecholamines and thyroxine are synthesized from tyrosine, ...... Catecholamines and thyroxine are synthesized from tyrosine, and serotonin and melatonin from tryptophan. More...

AANAT related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
AANAT	PRKACA	No	in vitro	11336675
AANAT	F2	No	in vitro	11427721
AANAT	YWHAZ	No	in vitro;in vivo	11336675 , 11427721

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways