Gene Report

Basic Information

Approved Symbol	MYO3A
Approved Name	myosin IIIA
Previous Symbol	DFNB30
Previous Name	deafness, autosomal recessive 30
Location	10p11.1
Position	chr10:26223002-26501465 (+)
External Links	Entrez Gene: 53904 Ensembl: ENSG00000095777 UCSC: uc001isn.2 HGNC ID: 7601
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between MYO3A and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
MYO3A	Unschuld, 2009	patients and normal controls		The associated SNPs lie within a 16KB linkage disequilibrium...... The associated SNPs lie within a 16KB linkage disequilibrium-block, including putative 5' GAD2-promoter-elements as well as the 3' end of the gene MYO3A. More...

Positive relationships between MYO3A and other components at different levels (count: 0)

Positive relationship network of MYO3A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between MYO3A and MDD (count: 0)

Negative relationships between MYO3A and other components at different levels (count: 0)

MYO3A related SNPs in MK4MDD (count: 0)

MYO3A related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Myosin-IIIa	Q8NEV4	0(0/0)	Gene mapped

MYO3A related GO terms (count: 29)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IDA[12672820]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0031941	filamentous actin	cellular component	IDA[12672820]
GO:0043531	ADP binding	molecular function	IDA[12672820]
GO:0007601	visual perception	biological process	IEA
GO:0032433	filopodium tip	cellular component	IEA
GO:0007605	sensory perception of sound	biological process	IMP[12032315]
GO:0051491	positive regulation of filopodium assembly	biological process	IEA
GO:0051015	actin filament binding	molecular function	IEA
GO:0005737	cytoplasm	cellular component	IEA
GO:0030898	actin-dependent ATPase activity	molecular function	IDA[12672820]
GO:0000146	microfilament motor activity	molecular function	IDA[1262820]; IMP[17021180]
GO:0046777	protein autophosphorylation	biological process	IDA[12672820]
GO:0018107	peptidyl-threonine phosphorylation	biological process	IEA
GO:0001917	photoreceptor inner segment	cellular component	IEA
GO:0030175	filopodium	cellular component	IDA[17021180]
GO:0005524	ATP binding	molecular function	IEA
GO:0060002	plus-end directed microfilament motor activity	molecular function	IDA[12672820]
GO:0004672	protein kinase activity	molecular function	IDA[12672820]
GO:0050896	response to stimulus	biological process	IEA
GO:0048839	inner ear development	biological process	IEA
GO:0032426	stereocilium bundle tip	cellular component	IEA
GO:0016459	myosin complex	cellular component	IEA
GO:0018105	peptidyl-serine phosphorylation	biological process	IEA
GO:0005516	calmodulin binding	molecular function	IDA[12672820]
GO:0004674	protein serine/threonine kinase activity	molecular function	IEA

MYO3A related KEGG pathways (count: 0)

MYO3A related BioCarta pathways (count: 0)

MYO3A related Reactome pathways (count: 0)

MYO3A related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
MYO3A	GRINL1A	No	yeast 2-hybrid	16169070
MYO3A	TGFBR1	No	in vivo	15761153

Gene Report

Literature-origin GO terms

Gene mapped GO terms