Pathway Report

Basic Information

Name	synaptic transmission
GO Link	ID: GO:0007268 Name: synaptic transmission Type: biological process
Description	Genes annotated by the GO term GO:0007268. The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
No. of Studies (Positive/Negative)	1 (1/0)

Positive relationship between synaptic transmission and MDD (count: 0)

Positive relationships between synaptic transmission and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Synaptic transmission		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model		genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...

Positive relationship network of synaptic transmission in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between synaptic transmission and MDD (count: 0)

Negative relationships between synaptic transmission and other components at different levels (count: 0)

Pathway synaptic transmission related genes in MK4MDD (count: 79)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Literature-origin; SNP mapped	4(3/1)
HCRTR1	hypocretin (orexin) receptor 1	Literature-origin; SNP mapped	2(2/0)
PMP22	peripheral myelin protein 22	Literature-origin	1(1/0)
CACNG3	calcium channel, voltage-dependent, gamma subunit 3	Literature-origin	1(1/0)
COMT	catechol-O-methyltransferase	Literature-origin; SNP mapped	6(6/0)
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	Literature-origin; SNP mapped	1(1/0)
GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	Literature-origin; SNP mapped	2(2/0)
GABRB2	gamma-aminobutyric acid (GABA) A receptor, beta 2	Literature-origin	2(2/0)
GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	Literature-origin; Protein mapped	1(1/0)
GALR2	galanin receptor 2	Literature-origin	1(1/0)
SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Literature-origin	1(1/0)
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	Literature-origin	1(1/0)
GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	Literature-origin	1(1/0)
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	Literature-origin; Protein mapped	1(1/0)
CORT	cortistatin	Literature-origin	1(1/0)
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	Literature-origin	1(1/0)
TAC1	tachykinin, precursor 1	Literature-origin; Protein mapped	2(2/0)
SLC17A7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	Literature-origin; Protein mapped	4(4/0)
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	Literature-origin; Protein mapped	2(2/0)
GRIA1	glutamate receptor, ionotropic, AMPA 1	Literature-origin; Protein mapped	1(1/0)
GNG3	guanine nucleotide binding protein (G protein), gamma 3	Literature-origin	1(1/0)
GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2	Literature-origin	2(2/0)
NPY	neuropeptide Y	Literature-origin; SNP mapped; Protein mapped	6(5/1)
MAPK1	mitogen-activated protein kinase 1	Literature-origin	2(2/0)
ADCY3	adenylate cyclase 3	Literature-origin; SNP mapped	1(0/1)
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Literature-origin; Protein mapped	3(3/0)
GABRG1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	Literature-origin	1(1/0)
GRIK5	glutamate receptor, ionotropic, kainate 5	Literature-origin	1(1/0)
KCND2	potassium voltage-gated channel, Shal-related subfamily, member 2	Literature-origin	1(1/0)
STX1A	syntaxin 1A (brain)	Literature-origin	1(1/0)
ADCY7	adenylate cyclase 7	Literature-origin; SNP mapped	2(2/0)
KCNN3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Literature-origin	1(1/0)
SLC18A2	solute carrier family 18 (vesicular monoamine), member 2	Literature-origin; Protein mapped	1(1/0)
HTR3B	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	Literature-origin; SNP mapped	1(1/0)
SYPL1	synaptophysin-like 1	Literature-origin	1(1/0)
KCNK2	potassium channel, subfamily K, member 2	Literature-origin; SNP mapped	2(2/0)
MBP	myelin basic protein	Literature-origin; Protein mapped	2(2/0)
GABRA2	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Literature-origin	1(1/0)
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Literature-origin; SNP mapped; Protein mapped	3(2/1)
GRM3	glutamate receptor, metabotropic 3	Literature-origin; SNP mapped; Protein mapped	3(3/0)
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	Literature-origin; SNP mapped; Protein mapped	5(4/1)
CREB1	cAMP responsive element binding protein 1	Literature-origin; Protein mapped	12(10/2)
SYN2	synapsin II	Literature-origin; Protein mapped	1(1/0)
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	Literature-origin	2(2/0)
GABRR1	gamma-aminobutyric acid (GABA) A receptor, rho 1	Literature-origin	1(1/0)
GRIK3	glutamate receptor, ionotropic, kainate 3	Literature-origin	1(1/0)
GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	Literature-origin	1(1/0)
GAD1	glutamate decarboxylase 1 (brain, 67kDa)	Literature-origin; Protein mapped	2(1/1)
GLRB	glycine receptor, beta	Literature-origin	1(1/0)
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Literature-origin; SNP mapped; Protein mapped	3(3/0)
GRM1	glutamate receptor, metabotropic 1	Literature-origin; SNP mapped	2(2/0)
DLG2	discs, large homolog 2 (Drosophila)	Literature-origin	1(1/0)
CNP	2',3'-cyclic nucleotide 3' phosphodiesterase	Literature-origin; Protein mapped	2(2/0)
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	Literature-origin; Protein mapped	2(2/0)
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	Literature-origin; Protein mapped	1(1/0)
SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	Literature-origin; Protein mapped	3(3/0)
AMPH	amphiphysin	Literature-origin; Protein mapped	1(1/0)
SNAP25	synaptosomal-associated protein, 25kDa	Literature-origin; Protein mapped	1(1/0)
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	Literature-origin	1(1/0)
GLUL	glutamate-ammonia ligase	Literature-origin; Protein mapped	3(3/0)
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	Literature-origin; SNP mapped; Protein mapped	9(7/2)
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	Literature-origin	1(1/0)
MAOA	monoamine oxidase A	Literature-origin; SNP mapped; Protein mapped	12(9/3)
SST	somatostatin	Literature-origin; Protein mapped	2(2/0)
ADCY8	adenylate cyclase 8 (brain)	Literature-origin	2(2/0)
SLC32A1	solute carrier family 32 (GABA vesicular transporter), member 1	Literature-origin; Protein mapped	1(1/0)
DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	Literature-origin; Protein mapped	1(1/0)
GRIA3	glutamate receptor, ionotropic, AMPA 3	Literature-origin; Protein mapped	1(1/0)
DLG4	discs, large homolog 4 (Drosophila)	Literature-origin; Protein mapped	1(1/0)
PLP1	proteolipid protein 1	Literature-origin	1(1/0)
GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	Literature-origin	2(2/0)
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	Literature-origin	1(1/0)
SYN1	synapsin I	Literature-origin; Protein mapped	1(1/0)
GNAL	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	Literature-origin; Protein mapped	1(0/1)
GRIA2	glutamate receptor, ionotropic, AMPA 2	Literature-origin	1(1/0)
CHRNA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	Literature-origin	1(1/0)
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	Literature-origin	1(1/0)
RAB3A	RAB3A, member RAS oncogene family	Literature-origin	1(1/0)
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	Literature-origin; Protein mapped	2(2/0)