Pathway Report

Basic Information

Name	inflammatory response
GO Link	ID: GO:0006954 Name: inflammatory response Type: biological process
Description	Genes annotated by the GO term GO:0006954. The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
No. of Studies (Positive/Negative)	2 (2/0)

Positive relationship between inflammatory response and MDD (count: 0)

Positive relationships between inflammatory response and other components at different levels (count: 2)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
inflammation		Aldosterone(aldosterone)	molecule	Hlavacova, 2011	animal model	Aldosterone treatment resulted in transcriptional changes of...... Aldosterone treatment resulted in transcriptional changes of genes in the hippocampus involved in inflammation. More...
Inflammatory response		Stress(stress)	environment	Tordera RM, 2011	animal model	After CMS, Specifically, a dowregulation in genes that promo...... After CMS, Specifically, a dowregulation in genes that promote cell proliferation (Anapc7), cell growth (CsnK1g1), cell survival (Hdac3), and inhibition of apoptosis (Dido1) was observed. Genes linked to cytoskeleton (Hspg2, Invs), psychiatric disorders (Grin1, MapK12) or an antioxidant enzyme (Gpx2) were also downregulated. Moreover, genes that inhibit the MAPK pathways (Dusp14), stimulate oxidative metabolism (Eif4a2) and enhance glutamate transmission (Rab8b) were upregulated. More...

Positive relationship network of inflammatory response in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between inflammatory response and MDD (count: 0)

Negative relationships between inflammatory response and other components at different levels (count: 0)

Pathway inflammatory response related genes in MK4MDD (count: 28)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
IL1B	interleukin 1, beta	Literature-origin; SNP mapped; Protein mapped	3(2/1)
CNR2	cannabinoid receptor 2 (macrophage)	Literature-origin	1(1/0)
PROK2	prokineticin 2	Literature-origin	1(1/0)
CRHBP	corticotropin releasing hormone binding protein	Literature-origin; SNP mapped; Protein mapped	2(1/1)
CCL2	chemokine (C-C motif) ligand 2	Literature-origin; SNP mapped; Protein mapped	2(1/1)
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	Literature-origin; Protein mapped	1(1/0)
LTA4H	leukotriene A4 hydrolase	Literature-origin	1(1/0)
IL18	interleukin 18 (interferon-gamma-inducing factor)	Literature-origin; Protein mapped	1(1/0)
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	Literature-origin; Protein mapped	2(2/0)
TNF	tumor necrosis factor	Literature-origin; SNP mapped; Protein mapped	5(5/0)
TAC1	tachykinin, precursor 1	Literature-origin; Protein mapped	2(2/0)
IL9	interleukin 9	Literature-origin	1(1/0)
IL8	interleukin 8	Literature-origin	1(1/0)
PRKCQ	protein kinase C, theta	Literature-origin	1(1/0)
HDAC5	histone deacetylase 5	Literature-origin	3(3/0)
IL6	interleukin 6 (interferon, beta 2)	Literature-origin; Protein mapped	1(0/1)
P2RX7	purinergic receptor P2X, ligand-gated ion channel, 7	Literature-origin; SNP mapped	6(5/1)
CRP	C-reactive protein, pentraxin-related	Literature-origin; Protein mapped	1(1/0)
IL1A	interleukin 1, alpha	Literature-origin	2(2/0)
GAL	galanin/GMAP prepropeptide	Literature-origin; SNP mapped	2(1/1)
IL5	interleukin 5 (colony-stimulating factor, eosinophil)	Literature-origin; Protein mapped	1(1/0)
IL13	interleukin 13	Literature-origin; Protein mapped	1(1/0)
IL10	interleukin 10	Literature-origin; Protein mapped	4(2/2)
FOS	FBJ murine osteosarcoma viral oncogene homolog	Literature-origin; Protein mapped	1(1/0)
NOS2	nitric oxide synthase 2, inducible	Literature-origin; SNP mapped	2(1/1)
IL15	interleukin 15	Literature-origin	2(2/0)
LIPA	lipase A, lysosomal acid, cholesterol esterase	Literature-origin	1(1/0)
TOLLIP	toll interacting protein	Literature-origin	1(1/0)