Gene Report

Basic Information

Approved Symbol	CRP
Approved Name	C-reactive protein, pentraxin-related
Symbol Alias	PTX1
Name Alias	"pentraxin 1"
Location	1q23.2
Position	chr1:159684276-159684379 (-)
External Links	Entrez Gene: 1401 Ensembl: ENSG00000132693 UCSC: uc001ftw.3 HGNC ID: 2367
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between CRP and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CRP	Bankier, 2009	patients and normal controls	beta=0.262, P-value=0.02	Stepwise multiple regression analyses showed a significant a...... Stepwise multiple regression analyses showed a significant association between MDD and CRP (beta=0.262, P=.02), excluding all other demographic and medical variables from the models, except age (beta=0.266, P=.02). More...

Positive relationships between CRP and other components at different levels (count: 0)

Positive relationship network of CRP in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CRP and MDD (count: 0)

Negative relationships between CRP and other components at different levels (count: 0)

CRP related SNPs in MK4MDD (count: 0)

CRP related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
C-reactive protein	P02741	9(8/1)	Literature-origin

CRP related GO terms (count: 20)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006954	inflammatory response	biological process	TAS[10408362]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0045908	negative regulation of vasodilation	biological process	IDA[24141169]; IMP[24141169]
GO:0010628	positive regulation of gene expression	biological process	IDA[24141169]
GO:0005576	extracellular region	cellular component	NAS[14718574]
GO:2000482	regulation of interleukin-8 secretion	biological process	IDA[21037097]
GO:0050750	low-density lipoprotein particle receptor binding	molecular function	IPI[24141169]
GO:0001849	complement component C1q binding	molecular function	IDA[23544079]
GO:0010745	negative regulation of macrophage derived foam cell differentiation	biological process	IDA[18322245]
GO:0005615	extracellular space	cellular component	IDA[23544079]
GO:0032930	positive regulation of superoxide anion generation	biological process	IDA[24141169]
GO:0005515	protein binding	molecular function	IPI[17785206\|21037097\|25416956]
GO:0030169	low-density lipoprotein particle binding	molecular function	IDA[18322245]
GO:0008228	opsonization	biological process	TAS[2477488]
GO:0070062	extracellular exosome	cellular component	IDA[23376485]
GO:0010888	negative regulation of lipid storage	biological process	IDA[18322245]
GO:0005509	calcium ion binding	molecular function	IDA[23544079]
GO:0050830	defense response to Gram-positive bacterium	biological process	TAS[2477488]
GO:0006953	acute-phase response	biological process	TAS[2477488]
GO:0033265	choline binding	molecular function	TAS[2477488]
GO:0046790	virion binding	molecular function	IDA[23544079]

CRP related KEGG pathways (count: 0)

CRP related BioCarta pathways (count: 0)

CRP related Reactome pathways (count: 0)

CRP related interactors from protein-protein interaction data in HPRD (count: 12)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CRP	FCGR1A	No	in vivo	12471137
CRP	HIST1H1A	No	in vivo	1989977
CRP	GP6	No	in vitro	11027634
CRP	HIST1H2AL	No	in vitro;in vivo	1989977
CRP	FCGR2B	No	in vivo	12471137
CRP	APCS	No	in vitro	8144569 , 1477104
CRP	CFH	No	in vitro;in vivo	10490997
CRP	CRP	Yes	in vitro	12037301 , 265538
CRP	SNRNP70	No	in vivo	2477447
CRP	FN1	No	in vitro	6693419
CRP	LEP	No	in vitro;in vivo	16582918
CRP	FCGR2A	No	in vivo	10675363

Gene Report

Literature-origin GO terms

Gene mapped GO terms