MK4MDD

Brain Morphology and Function Report

Basic Information
Name Orbitofrontal cortex
Brain Morphology "The orbitofrontal cortex (OFC) is a prefrontal cortex region in the frontal lobes in the brain which is involved in the cognitive processing of decision-making. It consists in non-human primates of the association cortex areas brodmann area 11, 12 and 13; in humans it consists of brodmann area 10, 11 and 47 Because of its functions in emotion and reward, the OFC is considered by some to be a part of the limbic system. The OFC anatomically is defined as the part of the prefrontal cortex that receives projections from the magnocellular, medial nucleus of the mediodorsal thalamus. It gets its name from its position immediately above the orbits in which are located the eyes."
Brain Function "The human OFC is among the least-understood regions of the human brain; but it has been proposed that the OFC is involved in sensory integration, in representing the affective value of reinforcers, and in decision-making and expectation. In particular, the human OFC is thought to regulate planning behavior associated with sensitivity to reward and punishment."
Picture Orbitofrontal cortex From Wiki. Magnify
No. of Studies (Positive/Negative) 34(34/0) Help

Positive relationships between Orbitofrontal cortex and MDD (count: 25)
Name in Literature Reference Research Type Statistical Result Relation Description Help
orbitofrontal cortex Smoski, 2009 patients and normal controls MDD participants showed hyperresponsivity in orbitofrontal c...... MDD participants showed hyperresponsivity in orbitofrontal cortex during reward selection. More...
orbitofrontal cortex Gron, 2002 patients and normal controls Contrasting patients who had major depressive disorder with ...... Contrasting patients who had major depressive disorder with seniors or patients who had Alzheimer's disease showed bilateral activation of the orbitofrontal cortex and the anterior cingulate. More...
orbitofrontal cortical volume Bremner, 2002 patients and normal controls 32% smaller Patients with depression had a statistically significant 32%...... Patients with depression had a statistically significant 32% smaller medial orbitofrontal (gyrus rectus) cortical volume More...
orbitofrontal cortex Ballmaier, 2004 patients and normal controls the depressed group showed significant CSF volume reductions...... the depressed group showed significant CSF volume reductions in the orbitofrontal cortex relative to the comparison subjects More...
orbitofrontal cortex (OFC) Lacerda, 2004 patients and normal controls in right medial two-way analysis of covariance F(1,60) = 4.285, P-value =.043; left lateral OFC F(1,60) = 4.252; P-value =.044 The MDD patients had smaller gray matter volumes in right me...... The MDD patients had smaller gray matter volumes in right medial [two-way analysis of covariance F(1,60) = 4.285; p =.043] and left lateral OFC [F(1,60) = 4.252; p =.044]. More...
orbitofrontal cortex Neumeister, 2004 patients and normal controls Compared with sham depletion, TD (tryptophan depletion) was ...... Compared with sham depletion, TD (tryptophan depletion) was associated with an increase in regional cerebral glucose utilization in the orbitofrontal cortex in patients with remitted MDD but not in controls. More...
orbitofrontal cortex Rajkowska, 2005 patients and normal controls decreased in MDD (by 30%) The overall (layers I-VI) packing density of ORB neurons wit...... The overall (layers I-VI) packing density of ORB neurons with pyramidal morphology was markedly decreased in MDD (by 30%) as compared with control subjects. More...
orbitofrontal cortex (OFC) Lavretsky, 2005 patients and normal controls P-value < .01 The depressed group had smaller corrected orbitofrontal cort...... The depressed group had smaller corrected orbitofrontal cortex (OFC) total and gray matter volumes compared to the controls (p < .01). More...
orbital cortex Dunn, 2005 patients and normal controls Unipolars had significantly fewer positive regional correlat...... Unipolars had significantly fewer positive regional correlation coefficients than healthy controls and bipolars. These were significantly different from controls in orbital cortex, anterior cingulate, posterior cingulate, and posterior temporal cortex More...
orbitofrontal cortex (ORB) Rajkowska, 2007 patients and normal controls The density of CB-IR neurons was significantly reduced by 50...... The density of CB-IR neurons was significantly reduced by 50% in depression in the dlPFC and there was a trend toward reduction in the ORB. The size of CB-IR somata was significantly decreased (18%) in depression in the dlPFC with a trend toward reduction in the ORB. More...
orbitofrontal cortex Bielau, 2007 patients and normal controls In the orbitofrontal cortex, a higher neuronal density was f...... In the orbitofrontal cortex, a higher neuronal density was found in bipolar and unipolar patients compared with controls. More...
orbitofrontal gray matter volumes Lavretsky, 2007 patients and normal controls The depressed group had smaller orbitofrontal gray matter vo...... The depressed group had smaller orbitofrontal gray matter volumes compared to the age-matched normal comparison group. More...
orbitofrontal cortex Wagner, 2008 patients and normal controls Voxel-based morphometry (VBM) revealed grey matter decreases...... Voxel-based morphometry (VBM) revealed grey matter decreases in the orbitofrontal cortex. The relative hyperactivation of the rACC in terms of inability to deactivate this region during the Stroop Color-Word Test showed an inverse correlation with grey matter reduction in the orbitofrontal cortex. More...
orbitofrontal cortex Stockmeier, 2009 patients and normal controls Antagonist of Serotonin-1A binding was significantly decreas...... Antagonist of Serotonin-1A binding was significantly decreased in outer layers of orbitofrontal cortex in MDD. More...
orbital frontal cortices Zhang, 2009 patients and normal controls Compared with healthy participants, patients with major depr...... Compared with healthy participants, patients with major depressive disorder showed significantly decreased local gyrification index in the orbital frontal cortices, More...
orbitofrontal cortex (OFC) Eddington, 2009 patients and normal controls patients showed significantly decreased left OFC and increas...... patients showed significantly decreased left OFC and increased right OFC activation compared to controls on trials in which they were exposed incidentally to their promotion and prevention goals More...
orbitofrontal cortex (OFC) Frodl, 2010 patients and normal controls The OFC plays a key role in the pathophysiology of major dep...... The OFC plays a key role in the pathophysiology of major depression. More...
orbitofrontal cortex van Wingen, 2010 patients and normal controls The fusiform gyrus was involved in memory formation and retr...... The fusiform gyrus was involved in memory formation and retrieval of happy faces in both patient groups, whereas it was involved in memory formation and retrieval of neutral faces in healthy individuals. Similar trait effects were observed during memory retrieval in the orbitofrontal cortex and left inferior frontal gyrus. More...
orbitofrontal cortex Scheuerecker, 2010 patients and normal controls As shown by voxel-based morphometry, depressed patients had ...... As shown by voxel-based morphometry, depressed patients had reductions in orbitofrontal cortex volume and increases in cerebellar volume. More...
orbitofrontal areas Hsu, 2010 patients and normal controls In MDD patients, positive correlations were found bilaterall...... In MDD patients, positive correlations were found bilaterally in orbitofrontal areas 11 l/47/12m, which are involved in representing negatively valenced stimuli. More...
orbitofrontal cortex Cooney, 2010 patients and normal controls Depressed participants exhibited increased activation in the...... Depressed participants exhibited increased activation in the orbitofrontal cortex, subgenual anterior cingulate, and dorsolateral prefrontal cortex as compared with healthy controls during rumination versus concrete distraction. More...
orbital cortices Nugent, 2011 patients and normal controls These results are consistent with the known roles of network...... These results are consistent with the known roles of networks within the orbital cortex in both autonomic control and the pathophysiology of MDD. More...
orbitofrontal cortex (OFC) Holsen, 2011 patients and normal controls fMRI results showed greater BOLD signal intensity changes in...... fMRI results showed greater BOLD signal intensity changes in controls versus MDD in hypothalamus, amygdala, hippocampus, OFC, ACC, and subgenual ACC, findings unrelated to medication status. More...
frontal (orbital part) regions Zhang, 2011 patients and normal controls The MDD patients exhibited reduced nodal centralities in the...... The MDD patients exhibited reduced nodal centralities in the frontal (orbital part) regions. More...
orbital frontal cortex Dichter, 2012 patients and normal controls During the outcome phase of the task, the rMDD group was cha...... During the outcome phase of the task, the rMDD group was characterized by relatively decreased activation in bilateral orbital frontal cortex, right frontal pole, left insular cortex, and left thalamus. More...

Positive relationships between Orbitofrontal cortex and other components at different levels (count: 34) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Orbitofrontal cortex in MK4MDD
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1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Orbitofrontal cortex and MDD (count: 0)
Negative relationships between Orbitofrontal cortex and other components at different levels (count: 0) Help