Protein Report

Protein Name	D(2) dopamine receptor
UniPortKB	P14416
No. of Studies (Positive/Negative)	10 (10/0)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
dopamine D2 receptor	D'Haenen H, 1994	patients and normal controls		The basal ganglia/cerebellum 123I-iodobenzamide (a high-affi...... The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. More...
dopamine D2 receptor	Shah, 1997	patients and normal controls		Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratio...... Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratios were significantly higher in depressed patients than controls. More...
dopamine D2 receptor	Klimek, 2002	patients and normal controls		The binding of [(125)I]epidepride to D2 receptors was signif...... The binding of [(125)I]epidepride to D2 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects. More...
D(2) receptor	Meyer, 2006	patients only		The depressed subjects exhibiting motor retardation had sign...... The depressed subjects exhibiting motor retardation had significantly higher D(2) binding potential in both the left and right putamen than did healthy subjects More...
D2 receptor	Montgomery, 2007	patients and normal controls		[(11)C]raclopride binding was reduced in the dorsal striatum...... [(11)C]raclopride binding was reduced in the dorsal striatum of people taking antidepressants suggesting that D(2/3) expression was reduced compared to untreated controls. More...
D2 receptor	Lehto, 2008	patients and normal controls		Among the major depressives there was a strong bilateral cor...... Among the major depressives there was a strong bilateral correlation between the scores on the 21-item Hamilton Depression Rating Scale and D(2/3) receptor binding. More...
D(2) receptor	Saijo, 2010	patients and normal controls		Electroconvulsive therapy decreased D(2) receptor binding in...... Electroconvulsive therapy decreased D(2) receptor binding in the rostral AC in MDD patients responding to ECT. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
dopamine D2 receptor		Basal ganglia(basal ganglia)	brain morphology and function	D'Haenen H, 1994	patients and normal controls		The basal ganglia/cerebellum 123I-iodobenzamide (a high-affi...... The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. More...
dopamine D2 receptor		Cerebellum(cerebellum)	brain morphology and function	D'Haenen H, 1994	patients and normal controls		The basal ganglia/cerebellum 123I-iodobenzamide (a high-affi...... The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. More...
dopamine D2 receptor		right striatum(right striatal region)	brain morphology and function	Shah, 1997	patients and normal controls		Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratio...... Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratios were significantly higher in depressed patients than controls. More...
dopamine D2 receptor		Amygdala(amygdaloid nuclei)	brain morphology and function	Klimek, 2002	patients and normal controls		The binding of [(125)I]epidepride to D2 receptors was signif...... The binding of [(125)I]epidepride to D2 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects. More...
D(2) receptor		Putamen(putamen)	brain morphology and function	Meyer, 2006	patients only		The depressed subjects exhibiting motor retardation had sign...... The depressed subjects exhibiting motor retardation had significantly higher D(2) binding potential in both the left and right putamen than did healthy subjects More...
D2 receptor		Striatum(striatum)	brain morphology and function	Montgomery, 2007	patients and normal controls		[(11)C]raclopride binding was reduced in the dorsal striatum...... [(11)C]raclopride binding was reduced in the dorsal striatum of people taking antidepressants suggesting that D(2/3) expression was reduced compared to untreated controls. More...
D(2) receptor		right rostral anterior cingulate(right rostral anterior cingulate)	brain morphology and function	Saijo, 2010	patients and normal controls	P-value < 0.001	Significant changes in D(2) receptor binding, a mean of 25.2...... Significant changes in D(2) receptor binding, a mean of 25.2% reduction, were found in the right rostral anterior cingulate (AC) following ECT (P < .001). More...
dopamine D2 receptor		Reaction time(reaction time)	cognition and behavior	Shah, 1997	patients and normal controls		There were significant correlations between 123I-IBZM (dopam...... There were significant correlations between 123I-IBZM (dopamine D2/3 ligand) binding in left and right striatum and measures of reaction time. More...
dopamine D2 receptor		Language(verbal fluency)	cognition and behavior	Shah, 1997	patients and normal controls		There were significant correlations between 123I-IBZM (dopam...... There were significant correlations between 123I-IBZM (dopamine D2/3 ligand) binding in left and right striatum and measures of verbal fluency. More...
dopamine D2 receptor		Anhedonia(anhedonia)	symptoms	Laruelle, 1995	normal people		The d-amphetamine injection induced a 15% +/- 4% (mean +/- s...... The d-amphetamine injection induced a 15% +/- 4% (mean +/- s.d.) decrease in D2 receptor availability. The d-amphetamine injection induced marked increase in euphoria scores. The intensity of these behavioral responses correlated with the decrease in D2 availability measured with SPECT. More...
dopamine D2 receptor		Increased agitation(psychomotor change)	symptoms	Laruelle, 1995	normal people		The d-amphetamine injection induced a 15% +/- 4% (mean +/- s...... The d-amphetamine injection induced a 15% +/- 4% (mean +/- s.d.) decrease in D2 receptor availability. The d-amphetamine injection induced marked increase in alertness and restlessness scores. The intensity of these behavioral responses correlated with the decrease in D2 availability measured with SPECT. More...
dopamine D2 receptor		Low energy(psychomotor retardation)	symptoms	Ebert, 1996	patients and normal controls		123I-IBZM (dopamine D2/3 ligand) binding was increased in de...... 123I-IBZM (dopamine D2/3 ligand) binding was increased in depressed patients with psychomotor retardation. More...
dopamine D2 receptor		Depressed mood(depressed mood)	symptoms	Willner, 2005	patients and normal controls		In the antidepressant-treated depressed patients, sulpiride ...... In the antidepressant-treated depressed patients, sulpiride caused a substantial reinstatement of depressed mood. More...
putamen D(2) receptor		Low energy(motor retardation)	symptoms	Meyer, 2006	patients only		The depressed subjects exhibiting motor retardation had sign...... The depressed subjects exhibiting motor retardation had significantly higher D(2) binding potential in both the left and right putamen than did healthy subjects, and putamen D(2) binding potential correlated significantly with motor speed in the depressed subjects. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
DRD2	dopamine receptor D2	Literature-origin; Protein mapped	4 (3/1)