MK4MDD

Protein Report

Basic Information
Protein Name D(2) dopamine receptor
UniPortKB P14416
No. of Studies (Positive/Negative) 10 (10/0) Help
Type Literature-origin
Positive relationship between D(2) dopamine receptor and MDD (count: 7)
Name in Literature Reference Research Type Statistical Result Relation Description Help
dopamine D2 receptor D'Haenen H, 1994 patients and normal controls The basal ganglia/cerebellum 123I-iodobenzamide (a high-affi...... The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. More...
dopamine D2 receptor Shah, 1997 patients and normal controls Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratio...... Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratios were significantly higher in depressed patients than controls. More...
dopamine D2 receptor Klimek, 2002 patients and normal controls The binding of [(125)I]epidepride to D2 receptors was signif...... The binding of [(125)I]epidepride to D2 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects. More...
D(2) receptor Meyer, 2006 patients only The depressed subjects exhibiting motor retardation had sign...... The depressed subjects exhibiting motor retardation had significantly higher D(2) binding potential in both the left and right putamen than did healthy subjects More...
D2 receptor Montgomery, 2007 patients and normal controls [(11)C]raclopride binding was reduced in the dorsal striatum...... [(11)C]raclopride binding was reduced in the dorsal striatum of people taking antidepressants suggesting that D(2/3) expression was reduced compared to untreated controls. More...
D2 receptor Lehto, 2008 patients and normal controls Among the major depressives there was a strong bilateral cor...... Among the major depressives there was a strong bilateral correlation between the scores on the 21-item Hamilton Depression Rating Scale and D(2/3) receptor binding. More...
D(2) receptor Saijo, 2010 patients and normal controls Electroconvulsive therapy decreased D(2) receptor binding in...... Electroconvulsive therapy decreased D(2) receptor binding in the rostral AC in MDD patients responding to ECT. More...

Positive relationships between D(2) dopamine receptor and other components at different levels (count: 14) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Positive relationship network of D(2) dopamine receptor in MK4MDD
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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between D(2) dopamine receptor and MDD (count: 0)
Negative relationships between D(2) dopamine receptor and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
DRD2 dopamine receptor D2 Literature-origin; Protein mapped 5 (3/2)