MK4MDD

Pathway Report

Basic Information
Name mapkkk cascade
GO Link ID: GO:0000165
Name: MAPK cascade
Type: biological process
Description Genes annotated by the GO term GO:0000165. Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
No. of Studies (Positive/Negative) 4 (4/0) Help

Positive relationship between mapkkk cascade and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
extracellular-regulated protein kinase (ERK) pathway Yuan, 2010 patients and normal controls Levels of most studied protein members of the ERK cascade we...... Levels of most studied protein members of the ERK cascade were lower in individuals with psychiatric disorders than controls More...

Positive relationships between mapkkk cascade and other components at different levels (count: 8) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of mapkkk cascade in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between mapkkk cascade and MDD (count: 0)
Negative relationships between mapkkk cascade and other components at different levels (count: 0) Help
Pathway mapkkk cascade related genes in MK4MDD (count: 41)