Cognition and Behavior Report

Name	Depression-like behaviors from animal model
Description	Depression-like behaviors from animal model.
No. of Studies (Positive/Negative)	12 (12/0)

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
depressive-like behavior		SETDB1(SETDB1)	gene	Jiang Y, 2010	animal model		Transgenic mice with increased Setdb1 expression in adult fo...... Transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. More...
depressive-like behavior		DUSP14(MKP-1)	gene	Duric, 2010	animal model		Increased hippocampal MKP-1 expression in rat causes depress...... Increased hippocampal MKP-1 expression in rat causes depressive behaviors More...
depression-like behavior		CLIC6(CLIC6)	gene	Andrus, 2010	animal model		Differentially expressed depression genes hippocampus, (fold...... Differentially expressed depression genes hippocampus, (fold change > 2). More...
depressive-like behavior		F5(F5)	gene	Andrus, 2010	animal model		Differentially expressed depression genes hippocampus, (fold...... Differentially expressed depression genes hippocampus, (fold change > 2). More...
depressive-like behavior		MFRP(MFRP)	gene	Andrus, 2010	animal model		Differentially expressed depression genes hippocampus, (fold...... Differentially expressed depression genes hippocampus, (fold change > 2). More...
depressive-like behavior		OTX2(OTX2)	gene	Andrus, 2010	animal model		Differentially expressed depression genes hippocampus, (fold...... Differentially expressed depression genes hippocampus, (fold change > 2). More...
depressive-like behavior		PRLR(PRLR)	gene	Andrus, 2010	animal model		Differentially expressed depression genes hippocampus, (fold...... Differentially expressed depression genes hippocampus, (fold change > 2). More...
depressive-like behavior		SLC4A4(SLC4A5)	gene	Andrus, 2010	animal model		Differentially expressed depression genes hippocampus, (fold...... Differentially expressed depression genes hippocampus, (fold change > 2). More...
depressive-like behavior		SOSTDC1(SOSTDC1)	gene	Andrus, 2010	animal model		Differentially expressed depression genes hippocampus, (fold...... Differentially expressed depression genes hippocampus, (fold change > 2). More...
depressive-like behavior		TTR(TTR)	gene	Andrus, 2010	animal model		Differentially expressed depression genes hippocampus, (fold...... Differentially expressed depression genes hippocampus, (fold change > 2). More...
depressive-like behavior		GALR2(galanin receptor 2)	gene	Wardi-Le Maitre, 2011	animal model		Three age groups of the transgenic mice (overexpressing a ga...... Three age groups of the transgenic mice (overexpressing a galanin receptor 2 (GalR2)-enhanced, green fluorescent protein (EGFP)-construct under the platelet-derived growth factor-B promoter) demonstrated decreased levels of immobility in the forced swim test, indicative of antidepressive-like behavior and/or increased stress resistance. More...
depressive-like behavior		TNFRSF1A(TNFR1)	gene	Simen BB, 2006	animal model		We show that deletion of either TNFR1 or TNFR2 leads to an a...... We show that deletion of either TNFR1 or TNFR2 leads to an antidepressant-like response in the forced swim test More...
depressive-like behavior		TNFRSF1B(TNFR2)	gene	Simen BB, 2006	animal model		We show that deletion of either TNFR1 or TNFR2 leads to an a...... We show that deletion of either TNFR1 or TNFR2 leads to an antidepressant-like response in the forced swim test More...
depressive-like behavior		ADCY7(AC7)	gene	Hines LM, 2006	animal model; patients and nomal controls		Genetic manipulation of AC7 influences depression-like behav...... Genetic manipulation of AC7 influences depression-like behavior in mice More...
depressive-like behavior		Protein S100-A10(p11)	protein	Svenningsson, 2006	animal model; patients and normal controls		p11 decreased in an animal model of depression and in brain ...... p11 decreased in an animal model of depression and in brain tissue from depressed patients. More...
depressive-like behavior		Brain-derived neurotrophic factor(BDNF)	protein	Schmidt HD, 2010	animal model		Peripheral BDNF administration increased mobility in the FST...... Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM More...
depressive-like behavior		B1 bradykinin receptor(Kinin B1 receptors)	protein	Viana AF, 2010	animal model		Depression-like behavior was significantly reduced by treatm...... Depression-like behavior was significantly reduced by treatment with the selective B1 receptor antagonists R-715 and SSR240612 More...
depressive-like behavior		Tumor necrosis factor(TNFalpha)	protein	Viana AF, 2010	animal model		The depression-like behavior was virtually abolished in TNFa...... The depression-like behavior was virtually abolished in TNFalpha p55 receptor-knockout mice More...
depressive-like behavior		Protein piccolo(piccolo)	protein	Furukawa-Hibi Y, 2010	animal model		To clarify the association of piccolo with depression, we pr...... To clarify the association of piccolo with depression, we produced a transgenic mouse overexpressing the C2A domain of piccolo, and investigated the behavior of these mice. The mice exhibited depression-like behavior in both forced swim and tail suspension tests, suggesting that piccolo might regulate the depressive behavior. More...
depressive-like behavior		Corticosterone(corticosterone)	molecule	Murray, 2008	animal model		Acute and 7 day but not 14 or 21 day treatment with corticos...... Acute and 7 day but not 14 or 21 day treatment with corticosterone gave rise to a depressed phenotype in the forced swim test. More...
depressive-like behavior		Flutamide(flutamide)	molecule	Zhang, 2010	animal model		Compared to the vehicle-treated controls, neonatal-flutamide...... Compared to the vehicle-treated controls, neonatal-flutamide treatment caused a significant increase in depression-like behaviors in preadolescent male rats More...
depressive-like behavior		R 715(R-715)	molecule	Viana AF, 2010	animal model		Depression-like behavior was significantly reduced by treatm...... Depression-like behavior was significantly reduced by treatment with the selective B1 receptor antagonists R-715 and SSR240612 More...
depressive-like behavior		SSR240612(SSR240612)	molecule	Viana AF, 2010	animal model		Depression-like behavior was significantly reduced by treatm...... Depression-like behavior was significantly reduced by treatment with the selective B1 receptor antagonists R-715 and SSR240612 More...
depressive-like behavior		Forebrain(forebrain)	brain morphology and function	Jiang Y, 2010	animal model		Transgenic mice with increased Setdb1 expression in adult fo...... Transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. More...

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