Molecule Report

Name	Corticosterone
Description	An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
MeSH ID	D003345
No. of Studies (Positive/Negative)	2(2/0)

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
corticosterone		Metabotropic glutamate receptor 5(metabotropic glutamate receptor subtype 5 (mGluR5))	protein	Iyo, 2010	animal model	P-value=0.0006	The results revealed that while there was a significant redu...... The results revealed that while there was a significant reduction (-27%, P=0.0006) in mGluR5 protein expression in the hippocampus from CORT treated rats, mRNA levels were unchanged. More...
corticosterone		granule cell(granule cell)	cell	Murray, 2008	animal model		Chronic (14 days) but not acute treatment with corticosteron...... Chronic (14 days) but not acute treatment with corticosterone resulted in reduced hippocampal cell proliferation and granule cell layer volume More...
corticosterone		Hippocampus(Hippocampus)	brain morphology and function	Murray, 2008	animal model		Chronic (14 days) but not acute treatment with corticosteron...... Chronic (14 days) but not acute treatment with corticosterone resulted in reduced hippocampal cell proliferation and granule cell layer volume More...
corticosterone		Anxiety-like behaviors from animal model(anxiety-like behavior)	cognition and behavior	Murray, 2008	animal model		Mice treated for 14 days with corticosterone also developed ...... Mice treated for 14 days with corticosterone also developed an anxious phenotype in the light dark box but only upon repeated testing More...
corticosterone		Depression-like behaviors from animal model(depressive-like behavior)	cognition and behavior	Murray, 2008	animal model		Acute and 7 day but not 14 or 21 day treatment with corticos...... Acute and 7 day but not 14 or 21 day treatment with corticosterone gave rise to a depressed phenotype in the forced swim test. More...

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