Gene Report

Basic Information

Approved Symbol	OTX2
Approved Name	orthodenticle homeobox 2
Previous Name	"orthodenticle homolog 2 (Drosophila)"
Location	14q22.3
Position	chr14:57277094-57277194 (-)
External Links	Entrez Gene: 5015 Ensembl: ENSG00000165588 UCSC: uc031qor.1 HGNC ID: 8522
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between OTX2 and MDD (count: 0)

Positive relationships between OTX2 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
OTX2		Depression-like behaviors from animal model(depressive-like behavior)	cognition and behavior	Andrus, 2010	animal model		Differentially expressed depression genes hippocampus, (fold...... Differentially expressed depression genes hippocampus, (fold change > 2). More...

Positive relationship network of OTX2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between OTX2 and MDD (count: 0)

Negative relationships between OTX2 and other components at different levels (count: 0)

OTX2 related SNPs in MK4MDD (count: 0)

OTX2 related proteins in MK4MDD (count: 0)

OTX2 related GO terms (count: 31)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0046982	protein heterodimerization activity	molecular function	IEA
GO:0007492	endoderm development	biological process	IEA
GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular function	IDA[12559959\|20530484]
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[12559959\|20530484]
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	biological process	TAS[15705863]
GO:0043234	protein complex	cellular component	IDA[20530484]
GO:0071542	dopaminergic neuron differentiation	biological process	IGI[19951692]; TAS[24431302]
GO:0009953	dorsal/ventral pattern formation	biological process	IEA
GO:0030901	midbrain development	biological process	TAS[15705863]
GO:0030900	forebrain development	biological process	TAS[15705863]
GO:0005515	protein binding	molecular function	IPI[20530484]
GO:0040019	positive regulation of embryonic development	biological process	ISS
GO:0008589	regulation of smoothened signaling pathway	biological process	TAS[15705863]
GO:0006366	transcription from RNA polymerase II promoter	biological process	IDA[12559959\|20530484]
GO:2000543	positive regulation of gastrulation	biological process	ISS
GO:0005634	nucleus	cellular component	IDA[24399192]
GO:0005737	cytoplasm	cellular component	IEA
GO:0090009	primitive streak formation	biological process	ISS
GO:0042472	inner ear morphogenesis	biological process	IEA
GO:0022037	metencephalon development	biological process	IEA
GO:0048664	neuron fate determination	biological process	IEA
GO:0007411	axon guidance	biological process	IDA[16267555]
GO:0048852	diencephalon morphogenesis	biological process	IEA
GO:0001708	cell fate specification	biological process	IEA
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular function	IDA[12559959]
GO:0030426	growth cone	cellular component	IDA[16267555]
GO:0032525	somite rostral/caudal axis specification	biological process	IEA
GO:0008190	eukaryotic initiation factor 4E binding	molecular function	TAS[15705863]
GO:0045893	positive regulation of transcription, DNA-templated	biological process	ISS
GO:0042706	eye photoreceptor cell fate commitment	biological process	IEA
GO:0006461	protein complex assembly	biological process	IDA[20530484]

OTX2 related KEGG pathways (count: 0)

OTX2 related BioCarta pathways (count: 0)

OTX2 related Reactome pathways (count: 0)

OTX2 related interactors from protein-protein interaction data in HPRD (count: 5)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
OTX2	TLE4	No	in vivo	15105370
OTX2	FOXA2	No	in vitro	10623575
OTX2	MITF	No	in vitro	12663655
OTX2	DMBX1	No	in vitro	15890343
OTX2	ATXN1	No	yeast 2-hybrid	16713569

Gene Report

Gene mapped GO terms