Pathway Report

Basic Information

Name	response to stress
GO Link	ID: GO:0006950 Name: response to stress Type: biological process
Description	Genes annotated by the GO term GO:0006950. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
No. of Studies (Positive/Negative)	1 (1/0)

Positive relationship between response to stress and MDD (count: 0)

Positive relationships between response to stress and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Response to stress		Stress(stress)	environment	Tordera RM, 2011	animal model		After CMS, Specifically, a dowregulation in genes that promo...... After CMS, Specifically, a dowregulation in genes that promote cell proliferation (Anapc7), cell growth (CsnK1g1), cell survival (Hdac3), and inhibition of apoptosis (Dido1) was observed. Genes linked to cytoskeleton (Hspg2, Invs), psychiatric disorders (Grin1, MapK12) or an antioxidant enzyme (Gpx2) were also downregulated. Moreover, genes that inhibit the MAPK pathways (Dusp14), stimulate oxidative metabolism (Eif4a2) and enhance glutamate transmission (Rab8b) were upregulated. More...

Positive relationship network of response to stress in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between response to stress and MDD (count: 0)

Negative relationships between response to stress and other components at different levels (count: 0)

Pathway response to stress related genes in MK4MDD (count: 9)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
PTK2B	protein tyrosine kinase 2 beta	Literature-origin	2(2/0)
CNR1	cannabinoid receptor 1 (brain)	Literature-origin; SNP mapped; Protein mapped	3(3/0)
TPH2	tryptophan hydroxylase 2	Literature-origin; SNP mapped; Protein mapped	11(10/1)
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	Literature-origin	1(1/0)
MAPK8	mitogen-activated protein kinase 8	Literature-origin	1(1/0)
STIP1	stress-induced-phosphoprotein 1	Literature-origin	1(1/0)
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	Literature-origin	1(0/1)
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	Literature-origin; SNP mapped; Protein mapped	9(7/2)
MAPK1	mitogen-activated protein kinase 1	Literature-origin	2(2/0)