MK4MDD

Brain Morphology and Function Report

Basic Information
Name Temporal Lobe
Brain Morphology The temporal lobe is a region of the cerebral cortex that is located beneath the Sylvian fissure on both cerebral hemispheres of the mammalian brain. The temporal lobe is involved in auditory perception and is home to the primary auditory cortex.
Brain Function "Temporal Lobe- associated with perception and recognition of auditory stimuli, memory, and speech"
Picture Temporal Lobe Source Magnify
No. of Studies (Positive/Negative) 18(18/0) Help

Positive relationships between Temporal Lobe and MDD (count: 14)
Name in Literature Reference Research Type Statistical Result Relation Description Help
temporal regions Sackeim, 1990 patients and normal controls Both approaches indicated that the depressed sample had an a...... Both approaches indicated that the depressed sample had an abnormality in topographic distribution of blood flow, in addition to the global deficit. The scaled subprofile model identified the topographic abnormality as being due to flow reduction in the depressed patients in selective frontal, central, superior temporal, and anterior parietal regions. More...
temporal cortices Messa, 2003 patients and normal controls P-value = 0.003 ANOVA; P-value = 0.001 ANCOVA A significant reduction in binding index (BI) of [(18)F]FESP...... A significant reduction in binding index (BI) of [(18)F]FESP ( P=0.003 ANOVA, P=0.001 ANCOVA) was found in DN(drug-naive) patients in the frontal, occipital, temporal and cingulate cortices More...
temporal lobe Agid, 2003 patients and normal controls P-value = 0.004 Mean volume of T2-WIH was significantly greater (p=0.004) in...... Mean volume of T2-WIH was significantly greater (p=0.004) in depressed subjects. In the control group T2-WIH(T2-weighted image 'hyperintensities') were exclusively located in the supratentorial hemispheral white matter while in the depressed group T2-WIH were also found in basal ganglia, temporal lobe, cerebellum and brainstem. More...
temporal regions Canli, 2004 patients and normal controls For happy words, depressed subjects exhibited less activatio...... For happy words, depressed subjects exhibited less activation than did controls to happy words in fronto-temporal and limbic regions. For sad words, depressed subjects showed more activation than did controls in the inferior parietal lobule and less activation in the superior temporal gyrus and cerebellum More...
parietotemporal cortical regions Oquendo, 2005 patients only Depressed borderline patients had greater relative activity ...... Depressed borderline patients had greater relative activity in parietotemporal cortical regions (BA 40, BA 22, and BA 42) before and after FEN (fenfluramine) activation compared to those without BPD (borderline personality disorder). Borderline pathology in the context of a Major Depressive Disorder is associated with altered activity in parietotemporal cortical regions. More...
temporal areas Langenecker, 2007 patients and normal controls The MDD participants had greater activation compared with th...... The MDD participants had greater activation compared with the control group in frontal and anterior temporal areas during correct rejections (inhibition). More...
temporal lobe Hasler, 2007 patients only Comorbid MDD was associated with a significantly more pronou...... Comorbid MDD was associated with a significantly more pronounced reduction in 5-HT(1A) receptor binding in TLE ( temporal lobe epilepsy) patients, extending into non-lesional limbic brain areas outside the epileptic focus. More...
temporal lobes Halari, 2009 patients and normal controls Adolescents with depression compared to healthy controls dem...... Adolescents with depression compared to healthy controls demonstrated reduced activation in putamen, insula and temporal lobes during the Switch task. More...
temporal regions Paquette, 2009 patients only Before treatment, excessive high-beta (18-30 Hz) activity wa...... Before treatment, excessive high-beta (18-30 Hz) activity was noted in several brain regions located in the fronto-temporal regions. More...
temporal lobe Abe, 2010 patients and normal controls Local areas showing an increase of MD (mean diffusivity) in ...... Local areas showing an increase of MD (mean diffusivity) in depressive patients were observed in the temporal lobe More...
temporal cortices Townsend, 2010 patients and normal controls In a between-group comparison, patients showed significantly...... In a between-group comparison, patients showed significantly reduced activation in the insula, temporal and occipital cortices. More...
temporal lobes Ahdidan, 2011 patients and normal controls Depressed patients were found to have smaller temporal lobes...... Depressed patients were found to have smaller temporal lobes bilaterally, medulla and right hippocampus at baseline. More...
temporal regions Zhang, 2011 patients and normal controls The MDD patients exhibited reduced nodal centralities in the...... The MDD patients exhibited reduced nodal centralities in the temporal regions. More...
temporal cortice Jin, 2011 patients and normal controls Our results showed that the topological properties of depres...... Our results showed that the topological properties of depressed adolescents' networks were significantly disrupted compared with HC. Dysregulation of brain regions were found in the temporal cortices. More...

Positive relationships between Temporal Lobe and other components at different levels (count: 5) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Temporal Lobe in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Temporal Lobe and MDD (count: 0)
Negative relationships between Temporal Lobe and other components at different levels (count: 0) Help