MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Lee, 2011 PubMed
Full Info	Lee, T.W., Yu, Y.W., Chen, M.C. and Chen, T.J. (2011) Cortical mechanisms of the symptomatology in major depressive disorder: a resting EEG study. J Affect Disord, 131, 243-250.

Study

Hypothesis or Background	Diagnosis and treatment rely on symptom criteria in modern psychiatry. However, the cortical mechanisms of symptomatology in major depressive disorder (MDD) are still not clear. This study examined neural correlates of symptom clusters of MDD by electroencephalography (EEG).
Sample Information	196 depressive patients
Method Detail	Resting state eye-closed EEG signals were recorded in 196 depressive patients. Quantitative EEG (qEEG) of regional power, coherence and power series correlation across delta, theta, alpha and beta frequencies were used to correlate with overall depression severity evaluated by the Hamilton Depression Rating Scale (HDRS). Further, statistical comparisons between patients with high vs. low qEEG indices (median-split) were undertaken regarding symptom severity of core depression, sleep, activity, psychic anxiety, somatic anxiety, and delusion.
Method Keywords	electroencephalogram (EEG)
Result	None of the qEEG indices significantly correlated with overall depression severity or differentiated symptom severity of core depression, sleep, activity and psychic anxiety. A higher symptom severity of somatic anxiety was associated with higher regional power over widespread cortical regions and lower strengths at bi-temporal, temporo-parietal and fronto-parietal connections. A higher symptom severity of delusion was associated with higher regional power in the frontal and temporal regions, and lower strengths at inter-hemispheric (frontal, temporal and parietal) and fronto-temporo-parietal connections.
Conclusions	Our results suggest that cortical mechanisms play important roles in the symptom manifestation of cognitive distortion (sub-score of delusion) and somatic anxiety in MDD. Our findings further imply that psychic anxiety and somatic anxiety are distinct entities.
Remark	LIMITATIONS: Our EEG recording with sampling rate of 128Hz and 20 electrodes may provide restricted spatial and temporal precision.

Relationships reported by Lee, 2011

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
Increased agitation (somatic anxiety)	symptoms	Fronto-parietal connection (fronto-parietal connection)	brain morphology and function		A higher symptom severity of somatic anxiety was associated with higher regional power over widespread cortical regions and lower strengths at bi-temporal, temporo-parietal and fronto-parietal connections.	Positive
Increased agitation (somatic anxiety)	symptoms	bi-temporal connection (bi-temporal connection)	brain morphology and function		A higher symptom severity of somatic anxiety was associated with higher regional power over widespread cortical regions and lower strengths at bi-temporal, temporo-parietal and fronto-parietal connections.	Positive
Psychotic symptoms (delusion)	symptoms	Frontal Lobe (frontal regions)	brain morphology and function		A higher symptom severity of delusion was associated with higher regional power in the frontal and temporal regions, and lower strengths at inter-hemispheric (frontal, temporal and parietal) and fronto-temporo-parietal connections.	Positive
Increased agitation (somatic anxiety)	symptoms	Temporo-parietal connection (temporo-parietal connection)	brain morphology and function		A higher symptom severity of somatic anxiety was associated with higher regional power over widespread cortical regions and lower strengths at bi-temporal, temporo-parietal and fronto-parietal connections.	Positive
Psychotic symptoms (delusion)	symptoms	Temporal Lobe (temporal regions)	brain morphology and function		A higher symptom severity of delusion was associated with higher regional power in the frontal and temporal regions, and lower strengths at inter-hemispheric (frontal, temporal and parietal) and fronto-temporo-parietal connections.	Positive
Psychotic symptoms (delusion)	symptoms	Parietal Lobe (parietal regions)	brain morphology and function		A higher symptom severity of delusion was associated with higher regional power in the frontal and temporal regions, and lower strengths at inter-hemispheric (frontal, temporal and parietal) and fronto-temporo-parietal connections.	Positive