MK4MDD

Brain Morphology and Function Report

Basic Information
Name Frontal Lobe
Brain Morphology "The frontal lobe is located at the front of each cerebral hemisphere and positioned anterior to the parietal lobes and superior and anterior to the temporal lobes. It is separated from the parietal lobe by the post-central gyrus primary motor cortex, which controls voluntary movements of specific body parts associated with the precentral gyrus posteriorly, inferiorly by lateral sulcus[slyvian] which separates it from the temporal lobe, superiorly by the superior margin of the hemisphere and anteriorly by the frontal pole. The frontal lobe contains most of the dopamine-sensitive neurons in the cerebral cortex."
Brain Function "Frontal Lobe- associated with reasoning, planning, parts of speech, movement, emotions, and problem solving"
Picture Frontal Lobe Source Magnify
No. of Studies (Positive/Negative) 16(15/1) Help

Positive relationships between Frontal Lobe and MDD (count: 12)
Name in Literature Reference Research Type Statistical Result Relation Description Help
frontal regions Aihara, 2007 patients only Prior to treatment of the unmedicated MDD, a significant hyp...... Prior to treatment of the unmedicated MDD, a significant hypometabolism in various frontal regions were observed compared with controls. More...
frontal gray matter volumes Steingard, 2002 patients and normal controls Significantly larger frontal gray matter volumes were found ...... Significantly larger frontal gray matter volumes were found in the depressed subjects, after controlling for age and whole brain volume. More...
frontal cortices Messa, 2003 patients and normal controls P-value = 0.003 ANOVA; P-value = 0.001 ANCOVA A significant reduction in binding index (BI) of [(18)F]FESP...... A significant reduction in binding index (BI) of [(18)F]FESP ( P=0.003 ANOVA, P=0.001 ANCOVA) was found in DN(drug-naive) patients in the frontal, occipital, temporal and cingulate cortices More...
frontal cortices Kano, 2004 patients and normal controls Binding (histamine H1 receptor (H(1)R) binding) potential va...... Binding (histamine H1 receptor (H(1)R) binding) potential values for [(11)C]-doxepin binding in the frontal and prefrontal cortices, and cingulate gyrus were significantly lower in the depressed patients than those in the normal control subjects. More...
frontal regions Perico, 2005 patients and normal controls Our findings confirmed the prediction that separate symptom ...... Our findings confirmed the prediction that separate symptom domains of the MDD syndrome are related to specific rCBF patterns, and extend results from prior studies that suggested the involvement of anterior cingulate, frontal, limbic and basal ganglia regions in the pathophysiology of MDD. More...
frontal lobes Taki, 2005 high-risk people and normal controls Male subjects with Sd(subthreshold depression) had significa...... Male subjects with Sd(subthreshold depression) had significantly smaller volumes of the medial part of the bilateral frontal lobes and the right precentral gyrus than normal male subjects. More...
frontal lobe volumes Frodl, 2006 patients and normal controls Hippocampal volumes and frontal lobe volumes were significan...... Hippocampal volumes and frontal lobe volumes were significantly smaller in patients, compared with healthy control subjects. More...
bilateral frontal gyri Hosokawa, 2009 patients and normal controls Compared with healthy controls, the depressed UP (unipolar m...... Compared with healthy controls, the depressed UP (unipolar mood disorder) patients showed significantly lower glucose metabolism in the bilateral frontal gyri. More...
frontal regions Werner, 2009 patients and normal controls during encoding, depressive patients showed increased activi...... during encoding, depressive patients showed increased activity in the left parahippocampal gyrus and decreased activity in frontal and parietal regions. More...
frontal regions Paquette, 2009 patients only Before treatment, excessive high-beta (18-30 Hz) activity wa...... Before treatment, excessive high-beta (18-30 Hz) activity was noted in several brain regions located in the fronto-temporal regions. More...
frontal lobe Wu, 2011 patients and normal controls Fractional anisotropy was significantly lower and apparent d...... Fractional anisotropy was significantly lower and apparent diffusion coefficient was significantly higher in the right superior longitudinal fasciculus (SLF) within the frontal lobe, right middle frontal and left parietal white matter in the MDD group compared with the healthy group. More...
frontal lobe Jarnum, 2011 patients and normal controls A significant decrease in perfusion in the frontal lobes in ...... A significant decrease in perfusion in the frontal lobes in non-remitters compared with healthy controls at baseline More...

Positive relationships between Frontal Lobe and other components at different levels (count: 3) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Frontal Lobe in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Frontal Lobe and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
frontal cortices Ballmaier, 2004 patients and normal controls No significant group differences were detected in frontal co...... No significant group differences were detected in frontal cortices or any other anatomical region. More...

Negative relationships between Frontal Lobe and other components at different levels (count: 0) Help