MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Perico, 2005 PubMed
Full Info	Perico, C.A., Skaf, C.R., Yamada, A., Duran, F., Buchpiguel, C.A., Castro, C.C., Soares, J.C. and Busatto, G.F. (2005) Relationship between regional cerebral blood flow and separate symptom clusters of major depression: a single photon emission computed tomography study using statistical parametric mapping. Neurosci Lett, 384, 265-270.

Study

Hypothesis or Background	This study examined the relationship between resting regional cerebral blood flow (rCBF) patterns in patients with major depressive disorder (MDD) and specific symptom clusters derived from ratings on the Hamilton Rating Scale for Depression (HRSD) and the Mini Mental State Examination. We hypothesized that the functional activity in frontal, parietal, anterior cingulate, basal ganglia and limbic regions would be related to specific symptom domains.
Sample Information	Fifteen patients fulfilling DSM-IV criteria for MDD who were off all psychotropic medications for >4 weeks and 15 normal volunteers were recruited.
Method Detail	Single photon emission computed tomography (SPECT) images were obtained after (99m)Tc-ECD injection, and correlations between rCBF patterns and symptom severity ratings were calculated on a voxel-by-voxel basis, using statistical parametric mapping (SPM).
Method Keywords	single photon emission computed tomography (SPECT)
Result	Severity of depressive mood was inversely correlated with rCBF in the left amygdala, lentiform nucleus, and parahippocampal gyrus, and directly correlated with rCBF in the right postero-lateral parietal cortex (p < 0.001, uncorrected for multiple comparisons). Insomnia severity was inversely correlated with rCBF in the right rostral and subgenual anterior cingulate cortices, insula and claustrum. Anxiety severity was directly correlated with rCBF in the right antero-lateral orbitofrontal cortex, while cognitive performance was directly correlated with rCBF in the right postero-medial orbitofrontal cortex and in the left lentiform nucleus.
Conclusions	Our findings confirmed the prediction that separate symptom domains of the MDD syndrome are related to specific rCBF patterns, and extend results from prior studies that suggested the involvement of anterior cingulate, frontal, limbic and basal ganglia regions in the pathophysiology of MDD.

Relationships reported by Perico, 2005

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
Depressed mood (depressive mood)	symptoms	right postero-lateral parietal cortex (right postero-lateral parietal cortex)	brain morphology and function		Severity of depressive mood was inversely correlated with rCBF in the left amygdala, lentiform nucleus, and parahippocampal gyrus, and directly correlated with rCBF in the right postero-lateral parietal cortex (p < 0.001, uncorrected for multiple comparisons).	Positive
Depressed mood (depressive mood)	symptoms	Parahippocampal gyrus (parahippocampal gyrus)	brain morphology and function	P-value < 0.001, uncorrected for multiple comparisons	Severity of depressive mood was inversely correlated with rCBF in the left amygdala, lentiform nucleus, and parahippocampal gyrus, and directly correlated with rCBF in the right postero-lateral parietal cortex (p < 0.001, uncorrected for multiple comparisons).	Positive
Increased agitation (anxiety)	symptoms	right antero-lateral orbitofrontal cortex (right antero-lateral orbitofrontal cortex)	brain morphology and function		Anxiety severity was directly correlated with rCBF in the right antero-lateral orbitofrontal cortex.	Positive
Depressed mood (depressive mood)	symptoms	Left amygdala (left amygdala)	brain morphology and function	P-value < 0.001, uncorrected for multiple comparisons	Severity of depressive mood was inversely correlated with rCBF in the left amygdala, lentiform nucleus, and parahippocampal gyrus, and directly correlated with rCBF in the right postero-lateral parietal cortex (p < 0.001, uncorrected for multiple comparisons).	Positive
Depressed mood (depressive mood)	symptoms	Lentiform nucleus (lentiform nucleus)	brain morphology and function	P-value < 0.001, uncorrected for multiple comparisons	Severity of depressive mood was inversely correlated with rCBF in the left amygdala, lentiform nucleus, and parahippocampal gyrus, and directly correlated with rCBF in the right postero-lateral parietal cortex (p < 0.001, uncorrected for multiple comparisons).	Positive
Sleep disturbances (insomnia)	symptoms	Claustrum (claustrum)	brain morphology and function		Insomnia severity was inversely correlated with rCBF in the right rostral and subgenual anterior cingulate cortices, insula and claustrum.	Positive
Sleep disturbances (insomnia)	symptoms	Insula (insula)	brain morphology and function		Insomnia severity was inversely correlated with rCBF in the right rostral and subgenual anterior cingulate cortices, insula and claustrum.	Positive
MDD	syndrome	Frontal Lobe (frontal regions)	brain morphology and function		Our findings confirmed the prediction that separate symptom domains of the MDD syndrome are related to specific rCBF patterns, and extend results from prior studies that suggested the involvement of anterior cingulate, frontal, limbic and basal ganglia regions in the pathophysiology of MDD.	Positive
MDD	syndrome	Basal ganglia (basal ganglia regions)	brain morphology and function		Our findings confirmed the prediction that separate symptom domains of the MDD syndrome are related to specific rCBF patterns, and extend results from prior studies that suggested the involvement of anterior cingulate, frontal, limbic and basal ganglia regions in the pathophysiology of MDD.	Positive
Sleep disturbances (insomnia)	symptoms	Anterior cingulate cortex (anterior cingulate cortices)	brain morphology and function		Insomnia severity was inversely correlated with rCBF in the right rostral and subgenual anterior cingulate cortices, insula and claustrum.	Positive
MDD	syndrome	Limbic lobe (limbic regions)	brain morphology and function		Our findings confirmed the prediction that separate symptom domains of the MDD syndrome are related to specific rCBF patterns, and extend results from prior studies that suggested the involvement of anterior cingulate, frontal, limbic and basal ganglia regions in the pathophysiology of MDD.	Positive
Cognitive performance (cognitive performance)	cognition and behavior	left lentiform nucleus (left lentiform nucleus)	brain morphology and function		Cognitive performance was directly correlated with rCBF in the right postero-medial orbitofrontal cortex and in the left lentiform nucleus.	Positive
MDD	syndrome	Anterior cingulate cortex (anterior cingulate)	brain morphology and function		Our findings confirmed the prediction that separate symptom domains of the MDD syndrome are related to specific rCBF patterns, and extend results from prior studies that suggested the involvement of anterior cingulate, frontal, limbic and basal ganglia regions in the pathophysiology of MDD.	Positive
Cognitive performance (cognitive performance)	cognition and behavior	right postero-medial orbitofrontal cortex (right postero-medial orbitofrontal cortex)	brain morphology and function		Cognitive performance was directly correlated with rCBF in the right postero-medial orbitofrontal cortex and in the left lentiform nucleus.	Positive