Pathway Report

Basic Information

Name	nucleotide binding
GO Link	ID: GO:0000166 Name: nucleotide binding Type: molecular function
Description	Genes annotated by the GO term GO:0000166. Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.
No. of Studies (Positive/Negative)	1 (1/0)

Positive relationship between nucleotide binding and MDD (count: 0)

Positive relationships between nucleotide binding and other components at different levels (count: 2)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
Nucleotide binding		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model	genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
Nucleotide binding		Stress(stress)	environment	Tordera RM, 2011	animal model	After CMS, Specifically, a dowregulation in genes that promo...... After CMS, Specifically, a dowregulation in genes that promote cell proliferation (Anapc7), cell growth (CsnK1g1), cell survival (Hdac3), and inhibition of apoptosis (Dido1) was observed. Genes linked to cytoskeleton (Hspg2, Invs), psychiatric disorders (Grin1, MapK12) or an antioxidant enzyme (Gpx2) were also downregulated. Moreover, genes that inhibit the MAPK pathways (Dusp14), stimulate oxidative metabolism (Eif4a2) and enhance glutamate transmission (Rab8b) were upregulated. More...

Positive relationship network of nucleotide binding in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between nucleotide binding and MDD (count: 0)

Negative relationships between nucleotide binding and other components at different levels (count: 0)

Pathway nucleotide binding related genes in MK4MDD (count: 10)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
SRSF10	serine/arginine-rich splicing factor 10	Literature-origin	1(1/0)
SYNJ2	synaptojanin 2	Literature-origin	1(1/0)
HSD17B6	hydroxysteroid (17-beta) dehydrogenase 6	Literature-origin	1(1/0)
CRY1	cryptochrome 1 (photolyase-like)	Literature-origin; SNP mapped	1(1/0)
AHCY	adenosylhomocysteinase	Literature-origin	1(1/0)
SFPQ	splicing factor proline/glutamine-rich	Literature-origin	1(1/0)
REV3L	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	Literature-origin	1(1/0)
RBM8A	RNA binding motif protein 8A	Literature-origin	1(1/0)
CELF2	CUGBP, Elav-like family member 2	Literature-origin	1(1/0)
MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Literature-origin	1(1/0)