Gene Report

Basic Information

Approved Symbol	HSD17B6
Approved Name	hydroxysteroid (17-beta) dehydrogenase 6
Previous Name	hydroxysteroid (17-beta) dehydrogenase 6, "hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)"
Symbol Alias	HSE, RODH, SDR9C6
Name Alias	oxidative 3-alpha-hydroxysteroid-dehydrogenase, "3(alpha->beta)-hydroxysteroid epimerasel", "retinol dehydrogenase", "oxidoreductase", "NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase", "3-hydroxysteroid epimerase", "short chain dehydrogenase/reductase family 9C, member 6"
Location	12q13.3
Position	chr12:57157108-57181574 (+)
External Links	Entrez Gene: 8630 Ensembl: ENSG00000025423 UCSC: uc001smg.1 HGNC ID: 23316
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between HSD17B6 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
3-Hydroxysteroid epimerase	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between HSD17B6 and other components at different levels (count: 0)

Positive relationship network of HSD17B6 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between HSD17B6 and MDD (count: 0)

Negative relationships between HSD17B6 and other components at different levels (count: 0)

HSD17B6 related SNPs in MK4MDD (count: 0)

HSD17B6 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
17-beta-hydroxysteroid dehydrogenase type 6	O14756	0(0/0)	Gene mapped

HSD17B6 related GO terms (count: 12)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0016491	oxidoreductase activity	molecular function	NAS[9188497]
GO:0000166	nucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0031901	early endosome membrane	cellular component	IEA
GO:0047035	testosterone dehydrogenase (NAD+) activity	molecular function	IEA
GO:0004745	retinol dehydrogenase activity	molecular function	IEA
GO:0009055	electron carrier activity	molecular function	TAS[9188497]
GO:0005783	endoplasmic reticulum	cellular component	IEA
GO:0006702	androgen biosynthetic process	biological process	NAS[9188497]
GO:0006710	androgen catabolic process	biological process	TAS[9188497]
GO:0004303	estradiol 17-beta-dehydrogenase activity	molecular function	IEA
GO:0003824	catalytic activity	molecular function	TAS[9188497]
GO:0005622	intracellular	cellular component	NAS[11513953]

HSD17B6 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa00140	steroid hormone_biosynthesis	Steroid hormone biosynthesis	Steroid hormones derived from cholesterol are a class of bio...... Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 compound, to the first C21 steroid, pregnenolone, which is converted by a bifunctional enzyme complex to the gestagen hormone, progesterone. Pregnenolone and progesterone are the starting materials for the three groups of steroids: C21 steroids of glucocorticoids and mineralocorticoids, C19 steroids of androgens, and C18 steroids of estrogens. (i) Progesterone is converted by hydroxylations at carbons 21 and 11 to corticosterone, which is further modified by hydroxylation and oxydoreduction at carbon 18 to yield aldosterone, a mineralcorticoid. Cortisol, the main glucocorticoid, is formed from 17alpha-hydroxyprogesterone with 11-deoxycortisol as an intermediate. (ii) Male hormone testosterone is formed from pregnenolone by two pathways, delta5 pathway via dehydroepiandrosterone and delta4 pathway via androstenedione. The enzyme CYP17A1 is responsible for the 17,20 lyase and 17alpha-hydroxylase activities in respective pathways. (iii) Female hormones estrone and estradiol are formed from testosterone and 4-androstene-3,17-dione by oxidative removal of the C19 methyl group and subsequent aromatization of ring A. In addition to these three groups, recent studies show that there is another group, termed neurosteroids, synthesized in the brain rather than the peripheral endocrine gland. More...

HSD17B6 related BioCarta pathways (count: 0)

HSD17B6 related Reactome pathways (count: 0)

HSD17B6 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways