Gene Report

Basic Information

Approved Symbol	AHCY
Approved Name	adenosylhomocysteinase
Previous Name	S-adenosylhomocysteine hydrolase
Symbol Alias	SAHH
Location	20q11.22
Position	chr20:32868071-32899608 (-)
External Links	Entrez Gene: 191 Ensembl: ENSG00000101444 UCSC: uc002xai.3 HGNC ID: 343
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between AHCY and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
S-adenosylhomocysteine hydrolase	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between AHCY and other components at different levels (count: 0)

Positive relationship network of AHCY in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between AHCY and MDD (count: 0)

Negative relationships between AHCY and other components at different levels (count: 0)

AHCY related SNPs in MK4MDD (count: 0)

AHCY related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Adenosylhomocysteinase	P23526	0(0/0)	Gene mapped

AHCY related GO terms (count: 11)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0000166	nucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0000096	sulfur amino acid metabolic process	biological process	TAS
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS
GO:0006805	xenobiotic metabolic process	biological process	TAS
GO:0032259	methylation	biological process	TAS
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0042470	melanosome	cellular component	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0005737	cytoplasm	cellular component	NAS
GO:0006730	one-carbon metabolic process	biological process	NAS
GO:0004013	adenosylhomocysteinase activity	molecular function	TAS

AHCY related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa00450	selenoamino acid_metabolism	Selenoamino acid metabolism
hsa00270	cysteine and_methionine_metabolism	Cysteine and methionine metabolism	Cysteine and methionine are sulfur-containing amino acids. C...... Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway. More...

AHCY related BioCarta pathways (count: 0)

AHCY related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_6959	phase ii_conjugation	Phase II of biotransformation is concerned with conjugation,...... Phase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involved are a set of transferases which perform the transfer of the cofactor group to the substrate. The resultant conjugation results in greatly increasing the excretory potential of compounds. Although most conjugations result in pharmacological inactivation or detoxification, some can result in bioactivation. Most of the phase II enzymes are located in the cytosol except UDP-glucuronosyltransferases (UGT), which are microsomal. Phase II reactions are typically much faster than phase I reactions therefore the rate-limiting step for biotransformation of a compound is usually the phase I reaction. Phase II metabolism can deal with all the products of phase I metabolism, be they reactive (Type I substrate) or unreactive/poorly active (Type II substrate) compounds. With the exception of glutathione, the conjugating species needs to be made chemically reactive after synthesis. The availability of the cofactor in the synthesis may be a rate-limiting factor in some phase II pathways as it may prevent the formation of enough conjugating species to deal with the substrate or it's metabolite. As many substrates and/or their metabolites are chemically reactive, their continued presence may lead to toxicity. More...
REACT_13433	biological oxidations	All organisms are constantly exposed to foreign chemicals ev...... All organisms are constantly exposed to foreign chemicals every day. These can be man-made. Once chemicals undergo functionalization, the electrophilic or nucleophilic species can be detrimental to biological systems. Electrophiles can react with electron-rich macromolecules such as proteins, DNA and RNA by covalent interaction whilst nucleophiles have the potential to interact with biological receptors. That's why conjugation is so important as it mops up these potentially reactive species. Many chemicals, when exposed to certain metabolizing enzymes can induce those enzymes, a process called enzyme induction. The effect of this is that these chemicals accelerate their own biotransformation and excretion. The reverse is also true where some chemicals cause enzyme inhibition. Some other factors that alter enzyme levels are sex, age and genetic predisposition. Between species, there can be considerable differences in biotransformation ability which is a problem faced by drug researchers interpreting toxicological results to humans. More...

AHCY related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways