Cognition and Behavior Report

Basic Information

Name	anhedonic-like behavior from animal model
No. of Studies (Positive/Negative)	16 (15/1)

Positive relationships betweenanhedonic-like behavior from animal model and MDD (count: 0)

Positive relationships between anhedonic-like behavior from animal model and other level components at different levels (count: 23)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
anhedonic-like behavior		BDNF(brain-derived neurotrophic factor (BDNF))	gene	Autry, 2009	animal model	The loss of BDNF lowers the threshold for female mice studie...... The loss of BDNF lowers the threshold for female mice studied at random throughout estrus to display anxiogenic and anhedonic behaviors after chronic stress compared with wild-type female mice. More...
anhedonic-like behavior		MBNL1(MBNL1 (Muscleblind-like 1))	gene	Matynia A, 2010	animal model	Cognitive and behavioral abnormalities were observed only in...... Cognitive and behavioral abnormalities were observed only in Mbnl1 deficient mice, which demonstrate behavior consistent with motivational deficits in the Morris water maze, a complex visuo-spatial task and in the sucrose consumption test for anhedonia. More...
anhedonic-like behavior		SETDB1(SETDB1)	gene	Jiang Y, 2010	animal model	Transgenic mice with increased Setdb1 expression in adult fo...... Transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. More...
anhedonic-like behavior		SLC17A7(VGLUT1)	gene	Tordera RM, 2011	animal model	VGLUT1 mice showed helpless and anhedonic-like behavior VGLUT1 mice showed helpless and anhedonic-like behavior
anhedonic-like behavior		TNFRSF1B(TNFR2)	gene	Simen BB, 2006	animal model	mice lacking TNFR2 demonstrate a hedonic response in a sucro...... mice lacking TNFR2 demonstrate a hedonic response in a sucrose drinking test compared with wildtype littermates More...
anhedonic-like behavior		Brain-derived neurotrophic factor(BDNF)	protein	Schmidt HD, 2010	animal model	Peripheral BDNF administration increased mobility in the FST...... Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM More...
anhedonic-like behavior		Cyclic AMP-responsive element-binding protein 1(cAMP response element-binding protein (CREB))	protein	Muschamp JW, 2011	animal model	Elevated CREB within the nucleus accumbens shell produced in...... Elevated CREB within the nucleus accumbens shell produced increases in intracranial self-stimulation thresholds, a depressive-like sign reflecting anhedonia More...
anhedonic-like behavior		Brain-derived neurotrophic factor(BDNF)	protein	Ye Y, 2011	animal model	Results revealed that CUMS induced anhedonic-like behaviors ...... Results revealed that CUMS induced anhedonic-like behaviors in sucrose consumption and open field performances, which were partially reversed by BDNF infusion More...
anhedonic-like behavior		Anabasine(nicotine (NC))	molecule	Hayase T, 2011	animal model	NC antagonized the IM-induced anhedonic attenuation of sucro...... NC antagonized the IM-induced anhedonic attenuation of sucrose consumption in the sucrose test More...
anhedonic-like behavior		Aldosterone(aldosterone)	molecule	Hlavacova, 2011	animal model	Aldosterone treatment induced an anhedonic state manifested ...... Aldosterone treatment induced an anhedonic state manifested by decreased sucrose preference More...
anhedonic-like behavior		apoptosis(Apoptosis)	pathway	Bergstrom A, 2007	animal model	upregulation of apoptotic pathway upregulation of apoptotic pathway
anhedonic-like behavior		mapkkk cascade(ERK pathway)	pathway	Qi X, 2009	animal model	The inhibition of the ERK pathway in dHP resulted in anhedon...... The inhibition of the ERK pathway in dHP resulted in anhedonia and anxiety-like behavior, and the ERK pathway inhibition in the mPFC induced anhedonia and locomotor impairment in rats More...
anhedonic-like behavior		Forebrain(forebrain)	brain morphology and function	Jiang Y, 2010	animal model	Transgenic mice with increased Setdb1 expression in adult fo...... Transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. More...
anhedonic-like behavior		Hippocampus(hippocampus)	brain morphology and function	Qi X, 2009	animal model	The inhibition of the ERK pathway in dorsal hippocampus resu...... The inhibition of the ERK pathway in dorsal hippocampus resulted in anhedonia and anxiety-like behavior More...
anhedonic-like behavior		Nucleus accumbens(nucleus accumbens (NAcc))	brain morphology and function	Muschamp JW, 2011	animal model	Elevated CREB within the nucleus accumbens shell produced in...... Elevated CREB within the nucleus accumbens shell produced increases in intracranial self-stimulation thresholds, a depressive-like sign reflecting anhedonia More...
anhedonic-like behavior		Fronto-parietal connection(frontal cortex)	brain morphology and function	Tordera RM, 2011	animal model	gene expression changes in the frontal cortex gene expression changes in the frontal cortex
anhedonic-like behavior		Fronto-parietal connection(frontal cortex)	brain morphology and function	Qi X, 2009	animal model	The ERK pathway inhibition in the medial prefrontal cortex i...... The ERK pathway inhibition in the medial prefrontal cortex induced anhedonia and locomotor impairment in rats More...
anhedonic-like behavior		Exploration in a novel environment(exploration in a novel environment)	cognition and behavior	Hollis F, 2011	animal model	Rats are known to exhibit either high locomotor activity and...... Rats are known to exhibit either high locomotor activity and sustained exploration consumed more sucrose solution than low activity with minimal exploration rats, but reduced consumption after exposure to defeat More...
anhedonic-like behavior		Stress(stress)	environment	Tordera RM, 2011	animal model	CMS mice showed helpless and anhedonic-like behavior CMS mice showed helpless and anhedonic-like behavior
anhedonic-like behavior		Stress(stress)	environment	Elizalde N, 2010	animal model	CMS-induced lasting anhedonia and region-specific changes in...... CMS-induced lasting anhedonia and region-specific changes in neuronal activity (c-Fos immunoreactivity) and neurotransmitter (glutamate and GABA) levels More...
anhedonic-like behavior		Stress(stress)	environment	Garcia-Garcia AL, 2009	animal model	CMS induced anhedonia, helplessness, anxiety, and impaired r...... CMS induced anhedonia, helplessness, anxiety, and impaired recognition memory More...
anhedonic-like behavior		Stress(stress)	environment	Hayase T, 2011	animal model	Depression-related anhedonic behavioral alterations, as judg...... Depression-related anhedonic behavioral alterations, as judged in the sucrose test, were observed only in the immobilization stress group More...
anhedonic-like behavior		Social defeat(social defeat)	environment	Hollis F, 2011	animal model	Rats are known to exhibit either high locomotor activity and...... Rats are known to exhibit either high locomotor activity and sustained exploration consumed more sucrose solution than low activity with minimal exploration rats, but reduced consumption after exposure to defeat More...

Positive relationship network of anhedonic-like behavior from animal model in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships betweenanhedonic-like behavior from animal model and MDD (count: 0)

Negative relationships between anhedonic-like behavior from animal model and other level components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
anhedonic-like behavior		Brain-derived neurotrophic factor(BDNF)	protein	Lucca G, 2008	animal model		BDNF protein levels were not significantly correlated with t...... BDNF protein levels were not significantly correlated with the decrease of sweet food consumption observed in CMS exposed animals More...