Study Report
Reference
| Citation | Muschamp JW, 2011 PubMed |
| Full Info | Muschamp JW, Van't Veer A, Parsegian A, Gallo MS, Chen M, Neve RL et al. Activation of CREB in the Nucleus Accumbens Shell Produces Anhedonia and Resistance to Extinction of Fear in Rats. J Neurosci 2011; 31(8): 3095-3103
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Study
| Hypothesis or Background |
Stress triggers psychiatric conditions including depressive and anxiety disorders. The mechanisms by which stress produces persistent changes in behavior are not fully understood.
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| Sample Information | rat |
|---|
| Method Detail | To determine whether neuroadaptations that produce anhedonia subsequently affect vulnerability to stress-induced behavioral adaptations, we subjected rats with altered CREB function in the NAS to fear conditioning |
| Method Keywords | transgenic method; fear conditioning |
| Result | Elevation of CREB impaired extinction of conditioned fear |
| Conclusions | These findings demonstrate that activation of CREB in the NAS produces multiple behavioral signs (anhedonia, impaired extinction) characteristic of experience-dependent psychiatric conditions such as posttraumatic stress disorder. Although CREB activation is a common trigger, expression of these individual signs appears to involve divergent downstream mechanisms. |
Relationships reported by
Muschamp JW, 2011
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
anhedonic-like behavior from animal model (anhedonic-like behavior)
|
cognition and behavior |
Nucleus accumbens (nucleus accumbens (NAcc)) |
brain morphology and function |
|
Elevated CREB within the nucleus accumbens shell produced increases in intracranial self-stimulation thresholds, a depressive-like sign reflecting anhedonia |
Positive
|
|
Emotion (conditioned fear)
|
cognition and behavior |
Nucleus accumbens (nucleus accumbens (NAcc)) |
brain morphology and function |
|
Elevation of CREB within the nucleus accumbens shell impaired extinction of conditioned fear |
Positive
|
|
Emotion (conditioned fear)
|
cognition and behavior |
Cyclic AMP-responsive element-binding protein 1 (cAMP response element-binding protein (CREB)) |
protein |
|
Elevation of CREB within the nucleus accumbens shell impaired extinction of conditioned fear |
Positive
|
|
anhedonic-like behavior from animal model (anhedonic-like behavior)
|
cognition and behavior |
Cyclic AMP-responsive element-binding protein 1 (cAMP response element-binding protein (CREB)) |
protein |
|
Elevated CREB within the nucleus accumbens shell produced increases in intracranial self-stimulation thresholds, a depressive-like sign reflecting anhedonia |
Positive
|
