MK4MDD

Protein Report

Basic Information
Protein Name Sodium-dependent serotonin transporter
UniPortKB P31645
No. of Studies (Positive/Negative) 17 (17/0) Help
Type Literature-origin
Positive relationship between Sodium-dependent serotonin transporter and MDD (count: 14)
Name in Literature Reference Research Type Statistical Result Relation Description Help
serotonin transporter (5-HTT) Ichimiya, 2002 patients and normal controls These findings may suggest the possibility of altered 5-HTT ...... These findings may suggest the possibility of altered 5-HTT in patients with mood disorders. More...
5HT transporter Ballard, 2002 patients only P-value<0.01 Major depression was associated with a significant preservat...... Major depression was associated with a significant preservation of 5HT transporter re-uptake sites in the parietal neocortex compared with non-affected cases (BA 7a area 1 t = 3.3, P = 0.004; BA 7a area 3 t = 3.8, P = 0.001). More...
serotonin transporter Lima, 2002 patients and normal controls Lymphocytes serotonin transporter number was significantly r...... Lymphocytes serotonin transporter number was significantly reduced, while the affinity was unchanged, in patients with major depression disorder as compare to controls. More...
serotonin transporter (5-HTT) Meyer, 2004 patients and normal controls P-value<0.01 In the MDE(major depressive episodes) subjects, increased 5-...... In the MDE(major depressive episodes) subjects, increased 5-HTT BP was strongly associated with more negativistic dysfunctional attitudes in brain regions primarily sampling serotonergic nerve terminals (prefrontal cortex, anterior cingulate, thalamus, caudate, and putamen; r = 0.64-0.74 [P values, .003 to <.001]). More...
serotonin transporter Newberg, 2005 patients and normal controls P-value = 0.01 (123)I-ADAM binding to SERT(serotonin transporter) in the mi...... (123)I-ADAM binding to SERT(serotonin transporter) in the midbrain was significantly lower (P = 0.01) in MDD patients (1.81 +/- 0.07) than in controls (1.95 +/- 0.13). More...
5-HT transporter Staley, 2006 patients and normal controls Diencephalon 5-HT transporter availability is decreased in d...... Diencephalon 5-HT transporter availability is decreased in depressed patients. More...
serotonin transporter Parsey, 2006 patients and normal controls Post hoc analysis revealed lower binding potential(serotonin...... Post hoc analysis revealed lower binding potential(serotonin transporter binding potential) in subjects with major depressive disorder, relative to the comparison subjects. The lower binding potential was more pronounced in the depressed subjects who had never received antidepressants. More...
5HTT Iritani, 2006 animal model The results showed more VMAT2-immunoreactive varicose fibers...... The results showed more VMAT2-immunoreactive varicose fibers in the pyramidal cell layer of hippocampus and parahippocampal cortexes, and more intense 5HTT-immunoreactivity in the pyramidal cell layer and the area CA4 of hippocampus in the animal models of depression compared to those of the controls. On the other hand, lower density of 5HT1a-immunoreactive deposits in the pyramidal cell layer of hippocampus and the parahippocampal cortex was observed in the animal models of depression compared to those of the controls. More...
serotonin transporter (5-HTT) Cannon, 2007 patients and normal controls Relative to the healthy group both MDD and BD groups showed ...... Relative to the healthy group both MDD and BD groups showed significantly increased 5-HTT BP in the thalamus (24%, 14%, respectively), insula (15%) and striatum (12%). The unipolar-depressives had elevated 5-HTT BP relative to both BD (bipolar-depressives) and HC (healthy-controls) groups in the vicinity of the periaqueductal gray (PAG, 20%, 22%, respectively). More...
serotonin transporter (5-HTT) Bhagwagar, 2007 patients and normal controls Men who recover from depression have normal availability of ...... Men who recover from depression have normal availability of 5-HTT in brain regions thought to be involved in the pathophysiology of depression. More...
serotonin transporters (5-HTT) Reimold, 2008 patients and normal controls P-value=0.005 Patients with major depression displayed reduced 5-HTT avail...... Patients with major depression displayed reduced 5-HTT availability in the thalamus (P=0.005). More...
serotonin transporter (5-HTT) Miller, 2008 patients and normal controls Non-remitters had lower 5-HTT binding than controls in midbr...... Non-remitters had lower 5-HTT binding than controls in midbrain, amygdala, and anterior cingulate. More...
serotonin transporter (5-HTT) Selvaraj, 2011 patients and normal controls The depressed patients had lowered 5-HTT binding in several ...... The depressed patients had lowered 5-HTT binding in several brain regions including brain stem, thalamus, caudate, putamen, anterior cingulate cortex and frontal cortex. More...
Serotonin transporter Rivera-Baltanas T, 2012 patients and normal controls We found an increase in SERT cluster size, but not the numbe...... We found an increase in SERT cluster size, but not the number of SERT clusters, in naive depression patients compared to control subjects. More...

Positive relationships between Sodium-dependent serotonin transporter and other components at different levels (count: 17) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Positive relationship network of Sodium-dependent serotonin transporter in MK4MDD
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1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Sodium-dependent serotonin transporter and MDD (count: 0)
Negative relationships between Sodium-dependent serotonin transporter and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 Literature-origin; Protein mapped 56 (44/12)