Protein Report

Protein Name	Sodium-dependent serotonin transporter
UniPortKB	P31645
No. of Studies (Positive/Negative)	17 (17/0)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
serotonin transporter (5-HTT)	Ichimiya, 2002	patients and normal controls		These findings may suggest the possibility of altered 5-HTT ...... These findings may suggest the possibility of altered 5-HTT in patients with mood disorders. More...
5HT transporter	Ballard, 2002	patients only	P-value<0.01	Major depression was associated with a significant preservat...... Major depression was associated with a significant preservation of 5HT transporter re-uptake sites in the parietal neocortex compared with non-affected cases (BA 7a area 1 t = 3.3, P = 0.004; BA 7a area 3 t = 3.8, P = 0.001). More...
serotonin transporter	Lima, 2002	patients and normal controls		Lymphocytes serotonin transporter number was significantly r...... Lymphocytes serotonin transporter number was significantly reduced, while the affinity was unchanged, in patients with major depression disorder as compare to controls. More...
serotonin transporter (5-HTT)	Meyer, 2004	patients and normal controls	P-value<0.01	In the MDE(major depressive episodes) subjects, increased 5-...... In the MDE(major depressive episodes) subjects, increased 5-HTT BP was strongly associated with more negativistic dysfunctional attitudes in brain regions primarily sampling serotonergic nerve terminals (prefrontal cortex, anterior cingulate, thalamus, caudate, and putamen; r = 0.64-0.74 [P values, .003 to <.001]). More...
serotonin transporter	Newberg, 2005	patients and normal controls	P-value = 0.01	(123)I-ADAM binding to SERT(serotonin transporter) in the mi...... (123)I-ADAM binding to SERT(serotonin transporter) in the midbrain was significantly lower (P = 0.01) in MDD patients (1.81 +/- 0.07) than in controls (1.95 +/- 0.13). More...
5-HT transporter	Staley, 2006	patients and normal controls		Diencephalon 5-HT transporter availability is decreased in d...... Diencephalon 5-HT transporter availability is decreased in depressed patients. More...
serotonin transporter	Parsey, 2006	patients and normal controls		Post hoc analysis revealed lower binding potential(serotonin...... Post hoc analysis revealed lower binding potential(serotonin transporter binding potential) in subjects with major depressive disorder, relative to the comparison subjects. The lower binding potential was more pronounced in the depressed subjects who had never received antidepressants. More...
5HTT	Iritani, 2006	animal model		The results showed more VMAT2-immunoreactive varicose fibers...... The results showed more VMAT2-immunoreactive varicose fibers in the pyramidal cell layer of hippocampus and parahippocampal cortexes, and more intense 5HTT-immunoreactivity in the pyramidal cell layer and the area CA4 of hippocampus in the animal models of depression compared to those of the controls. On the other hand, lower density of 5HT1a-immunoreactive deposits in the pyramidal cell layer of hippocampus and the parahippocampal cortex was observed in the animal models of depression compared to those of the controls. More...
serotonin transporter (5-HTT)	Cannon, 2007	patients and normal controls		Relative to the healthy group both MDD and BD groups showed ...... Relative to the healthy group both MDD and BD groups showed significantly increased 5-HTT BP in the thalamus (24%, 14%, respectively), insula (15%) and striatum (12%). The unipolar-depressives had elevated 5-HTT BP relative to both BD (bipolar-depressives) and HC (healthy-controls) groups in the vicinity of the periaqueductal gray (PAG, 20%, 22%, respectively). More...
serotonin transporter (5-HTT)	Bhagwagar, 2007	patients and normal controls		Men who recover from depression have normal availability of ...... Men who recover from depression have normal availability of 5-HTT in brain regions thought to be involved in the pathophysiology of depression. More...
serotonin transporters (5-HTT)	Reimold, 2008	patients and normal controls	P-value=0.005	Patients with major depression displayed reduced 5-HTT avail...... Patients with major depression displayed reduced 5-HTT availability in the thalamus (P=0.005). More...
serotonin transporter (5-HTT)	Miller, 2008	patients and normal controls		Non-remitters had lower 5-HTT binding than controls in midbr...... Non-remitters had lower 5-HTT binding than controls in midbrain, amygdala, and anterior cingulate. More...
serotonin transporter (5-HTT)	Selvaraj, 2011	patients and normal controls		The depressed patients had lowered 5-HTT binding in several ...... The depressed patients had lowered 5-HTT binding in several brain regions including brain stem, thalamus, caudate, putamen, anterior cingulate cortex and frontal cortex. More...
Serotonin transporter	Rivera-Baltanas T, 2012	patients and normal controls		We found an increase in SERT cluster size, but not the numbe...... We found an increase in SERT cluster size, but not the number of SERT clusters, in naive depression patients compared to control subjects. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
serotonin transporter (5-HTT)		HTR2A(HTR2A)	gene	Laje, 2010	patients and normal controls		Genetic variation in HTR2A that was previously associated wi...... Genetic variation in HTR2A that was previously associated with citalopram treatment outcome was also associated with thalamic 5-HTT binding. More...
serotonin transporter (5-HTT)		Anterior cingulate cortex(anterior cingulate)	brain morphology and function	Meyer, 2004	patients and normal controls	P-value<0.01	In the MDE(major depressive episodes) subjects, increased 5-...... In the MDE(major depressive episodes) subjects, increased 5-HTT BP was strongly associated with more negativistic dysfunctional attitudes in brain regions primarily sampling serotonergic nerve terminals (prefrontal cortex, anterior cingulate, thalamus, caudate, and putamen; r = 0.64-0.74 [P values, .003 to <.001]). More...
serotonin transporter (5-HTT)		Caudate nucleus(caudate)	brain morphology and function	Meyer, 2004	patients and normal controls	P-value<0.01	In the MDE(major depressive episodes) subjects, increased 5-...... In the MDE(major depressive episodes) subjects, increased 5-HTT BP was strongly associated with more negativistic dysfunctional attitudes in brain regions primarily sampling serotonergic nerve terminals (prefrontal cortex, anterior cingulate, thalamus, caudate, and putamen; r = 0.64-0.74 [P values, .003 to <.001]). More...
serotonin transporter (5-HTT)		Prefrontal cortex(prefrontal cortex)	brain morphology and function	Meyer, 2004	patients and normal controls	P-value<0.01	In the MDE(major depressive episodes) subjects, increased 5-...... In the MDE(major depressive episodes) subjects, increased 5-HTT BP was strongly associated with more negativistic dysfunctional attitudes in brain regions primarily sampling serotonergic nerve terminals (prefrontal cortex, anterior cingulate, thalamus, caudate, and putamen; r = 0.64-0.74 [P values, .003 to <.001]). More...
serotonin transporter (5-HTT)		Putamen(putamen)	brain morphology and function	Meyer, 2004	patients and normal controls	P-value<0.01	In the MDE(major depressive episodes) subjects, increased 5-...... In the MDE(major depressive episodes) subjects, increased 5-HTT BP was strongly associated with more negativistic dysfunctional attitudes in brain regions primarily sampling serotonergic nerve terminals (prefrontal cortex, anterior cingulate, thalamus, caudate, and putamen; r = 0.64-0.74 [P values, .003 to <.001]). More...
serotonin transporter (5-HTT)		Thalamus(thalamus)	brain morphology and function	Meyer, 2004	patients and normal controls	P-value<0.01	In the MDE(major depressive episodes) subjects, increased 5-...... In the MDE(major depressive episodes) subjects, increased 5-HTT BP was strongly associated with more negativistic dysfunctional attitudes in brain regions primarily sampling serotonergic nerve terminals (prefrontal cortex, anterior cingulate, thalamus, caudate, and putamen; r = 0.64-0.74 [P values, .003 to <.001]). More...
5-HT transporter		Diencephalon(diencephalon)	brain morphology and function	Staley, 2006	patients and normal controls		Diencephalon 5-HT transporter availability is decreased in d...... Diencephalon 5-HT transporter availability is decreased in depressed patients. More...
serotonin transporter		Amygdala(amygdala)	brain morphology and function	Parsey, 2006	patients and normal controls		Post hoc analysis revealed lower binding potential(serotonin...... Post hoc analysis revealed lower binding potential(serotonin transporter binding potential) in subjects with major depressive disorder, relative to the comparison subjects, in the amygdala More...
serotonin transporter		Midbrain(midbrain)	brain morphology and function	Parsey, 2006	patients and normal controls		Post hoc analysis revealed lower binding potential(serotonin...... Post hoc analysis revealed lower binding potential(serotonin transporter binding potential) in subjects with major depressive disorder, relative to the comparison subjects, in the midbrain. More...
serotonin transporter (5-HTT)		Amygdala(amygdala)	brain morphology and function	Miller, 2008	patients and normal controls		Non-remitters had lower 5-HTT binding than controls in midbr...... Non-remitters had lower 5-HTT binding than controls in midbrain, amygdala, and anterior cingulate. More...
serotonin transporter (5-HTT)		Anterior cingulate cortex(anterior cingulate)	brain morphology and function	Miller, 2008	patients and normal controls		Non-remitters had lower 5-HTT binding than controls in midbr...... Non-remitters had lower 5-HTT binding than controls in midbrain, amygdala, and anterior cingulate. More...
serotonin transporter (5-HTT)		Midbrain(midbrain)	brain morphology and function	Miller, 2008	patients and normal controls		Non-remitters had lower 5-HTT binding than controls in midbr...... Non-remitters had lower 5-HTT binding than controls in midbrain, amygdala, and anterior cingulate. More...
serotonin transporter (5-HTT)		Attribution and attitude(negativistic dysfunctional attitudes)	cognition and behavior	Meyer, 2004	patients and normal controls	P-value<0.01	In the MDE(major depressive episodes) subjects, increased 5-...... In the MDE(major depressive episodes) subjects, increased 5-HTT BP was strongly associated with more negativistic dysfunctional attitudes in brain regions primarily sampling serotonergic nerve terminals (prefrontal cortex, anterior cingulate, thalamus, caudate, and putamen; r = 0.64-0.74 [P values, .003 to <.001]). More...
serotonin transporter (5-HTT)		Depressed mood(depression)	symptoms	Cannon, 2007	patients and normal controls		Depression-severity correlated negatively with 5-HTT BP in t...... Depression-severity correlated negatively with 5-HTT BP in the thalamus in MDD-subjects. More...
serotonin transporters (5-HTT)		Increased agitation(anxiety)	symptoms	Reimold, 2008	patients and normal controls	P-value<0.01	In patients, low serotonin transporter availability correlat...... In patients, low serotonin transporter availability correlated with high anxiety (thalamus: r=-0.78, P=0.004; midbrain: r=-0.78, P=0.004; amygdala: r=-0.80, P=0.003). More...
serotonin transporter		Season(season)	environment	Ruhe, 2009	patients and normal controls	P-value = 0.018	In the midbrain the season of scanning showed a significant ...... In the midbrain the season of scanning showed a significant main effect (p = 0.018) with higher serotonin transporter (SERT) availability in winter. More...
brain serotonin transporter (5-HTT)		Child abuse(childhood abuse)	environment	Miller, 2009	patients only	P-value = 0.017	Depressed subjects reporting childhood abuse had lower 5-HTT...... Depressed subjects reporting childhood abuse had lower 5-HTT BP(P) than nonabused depressed subjects across all brain regions examined (P = 0.017). More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Literature-origin; Protein mapped	51 (43/8)