MK4MDD

Symptoms Report

Basic Information
Name Sleep disturbances
Description "Sleep disturbances mainly include insomnia and hypersomnia. Insomnia is most often defined by an individual's report of sleeping difficulties. Insomnia is typically followed by functional impairment while awake. One definition of insomnia is difficulties initiating and/or maintaining sleep, or nonrestorative sleep, associated with impairments of daytime functioning or marked distress for more than 1 month. Hypersomnia is a disorder characterized by excessive amounts of sleepiness. Hypersomnia can be caused by brain damage and disorders such as clinical depression. Insomnia affects at least 80% of depressed people. Hypersomnia, or oversleeping, can also happen, affecting 15% of depressed people."
No. of Studies (Positive/Negative) 32 (32/0) Help

Positive relationship between Sleep disturbances and MDD (count: 18)
Name in Literature Reference Research Type Statistical Result Relation Description Help
sleep dysregulation Emslie, 2001 patients only P-value = 0.005 On baseline sleep polysomnography, subjects with a later rec...... On baseline sleep polysomnography, subjects with a later recurrence had decreased sleep efficiency and delayed sleep onset (sleep latency > 10 min). Probability of recurrence at 12 months was 0.39 compared to 0.15 in subjects with non-delayed sleep onset (p = 0.005). Baseline suicidal ideation and sleep dysregulation on sleep polysomnography predicted recurrence in a large sample of depressed children and adolescents. More...
sleep continuity disturbances Staner, 2003 patients only Compared to the two other clusters, cluster I (n=26) patient...... Compared to the two other clusters, cluster I (n=26) patients showed the most severe sleep continuity disturbances. More...
sleep alterations Antonijevic, 2003 patients and normal controls Sleep alterations typically associated with depression, name...... Sleep alterations typically associated with depression, namely a reduction in sleep continuity and slow wave sleep (SWS) and an increase in REM density, were prominent in post- but not in premenopausal patients. More...
sleep disorders Serretti, 2004 patients only The most frequently represented depressive symptoms in MDD w...... The most frequently represented depressive symptoms in MDD were Loss of energy/tiredness, Loss of pleasure, Poor concentration, and Sleep disorders. More...
sleep disorders Bertocci, 2005 patients and normal controls Depressed subjects reported significantly worse sleep on fou...... Depressed subjects reported significantly worse sleep on four scales: subjective sleep quality, perceived number of awakenings, estimated minutes awake, and perceived ease of waking. I More...
insomnia Perlis, 2006 normal people These data suggest that elderly participants with persistent...... These data suggest that elderly participants with persistent insomnia are at greater risk for the development of new onset depression. More...
hypersomnia Liu, 2007 patients only 9.0% had hypersomnia alone Of the total sample, 72.7% had sleep disturbance: 53.5% had ...... Of the total sample, 72.7% had sleep disturbance: 53.5% had insomnia alone, 9.0% had hypersomnia alone, and 10.1% had both disturbances. More...
insomnia Liu, 2007 patients only 53.5% had insomnia alone Of the total sample, 72.7% had sleep disturbance: 53.5% had ...... Of the total sample, 72.7% had sleep disturbance: 53.5% had insomnia alone, 9.0% had hypersomnia alone, and 10.1% had both disturbances. More...
sleep disturbance Liu, 2007 patients only 72.7% had sleep disturbance Of the total sample, 72.7% had sleep disturbance: 53.5% had ...... Of the total sample, 72.7% had sleep disturbance: 53.5% had insomnia alone, 9.0% had hypersomnia alone, and 10.1% had both disturbances. More...
sleep disturbance Lopes, 2007 patients and normal controls MDD patients had evidence of disturbed sleep with both analy...... MDD patients had evidence of disturbed sleep with both analyses, but CAP(cyclic alternating pattern analysis) revealed more important changes in NREM(non-rapid eye movement) sleep of MDD patients at baseline than did conventional sleep staging. More...
sleep disturbance Forbes, 2008 patients and normal controls The MDD group exhibited less time awake than the control gro...... The MDD group exhibited less time awake than the control group and less stage 1 sleep than the anxiety or control group. More...
sleep disturbances Friess, 2008 patients and normal controls As expected patients with depression showed disturbed sleep ...... As expected patients with depression showed disturbed sleep continuity and prolonged latency until slow wave sleep in the first sleep cycle. More...
insomnia Gureje, 2009 normal people OR = 3.9, 95% CI 2.5-6.1 Insomnia was comorbid with major depressive disorder (OR = 3...... Insomnia was comorbid with major depressive disorder (OR = 3.9, 95% CI 2.5-6.1) More...
oversleeping Yonkers, 2009 patients and normal controls Appetite increase, oversleeping and increase in energy (e.g....... Appetite increase, oversleeping and increase in energy (e.g., agitation) were uninformative with regard to an MDD diagnosis. More...
insomnia van Mill, 2010 patients only ORs for insomnia ranging from 1.42 to 3.23 Both current and remitted depressive disorder and current an...... Both current and remitted depressive disorder and current anxiety disorder were associated with insomnia and short sleep duration with odds ratios (ORs) for insomnia ranging from 1.42 to 3.23 and for short sleep duration ranging from 1.41 to 2.53. More...
sleep disturbance Yetkin, 2010 patients and normal controls Compared to the normal controls, the PTSD (post-traumatic st...... Compared to the normal controls, the PTSD (post-traumatic stress disorder) patients with MDD had difficulty initiating sleep, poor sleep efficiency, decreased total sleep time, decreased slow wave sleep (SWS), and a reduced rapid eye movement (REM) sleep latency. More...
insomnia Sunderajan, 2010 patients only Insomnia symptoms were associated with several indicators of...... Insomnia symptoms were associated with several indicators of a more severe depressive illness. More...
insomnia O'Brien, 2011 patients only Among the patients with MDD, 24.7% endorsed severe insomnia ...... Among the patients with MDD, 24.7% endorsed severe insomnia symptoms. More...

Positive relationships between Sleep disturbances and other components at different levels (count: 28) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Sleep disturbances in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
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Negative relationships between Sleep disturbances and MDD (count: 0)
Negative relationships between Sleep disturbances and other components at different levels (count: 0) Help