Pathway Report

Basic Information

Name	Regulation of actin cytoskeleton
KEGG Link	ID: hsa04810 Name: regulation of_actin_cytoskeleton Brief Description: Regulation of actin cytoskeleton Full Description:
No. of Studies (Positive/Negative)	1 (1/0)

Positive relationship between Regulation of actin cytoskeleton and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Regulation of actin cytoskeleton	Kao CF, 2012	patients and normal controls		We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

Positive relationships between Regulation of actin cytoskeleton and other components at different levels (count: 0)

Positive relationship network of Regulation of actin cytoskeleton in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between Regulation of actin cytoskeleton and MDD (count: 0)

Negative relationships between Regulation of actin cytoskeleton and other components at different levels (count: 0)

Pathway Regulation of actin cytoskeleton related genes in MK4MDD (count: 31)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
GSN	gelsolin	Protein mapped	0(0/0)
RHOA	ras homolog family member A	Literature-origin	1(1/0)
MYL10	myosin, light chain 10, regulatory	Literature-origin	1(1/0)
MSN	moesin	Literature-origin	1(1/0)
EGF	epidermal growth factor	Literature-origin; SNP mapped; Protein mapped	1(0/1)
NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	Protein mapped	0(0/0)
CHRM2	cholinergic receptor, muscarinic 2	Literature-origin; SNP mapped; Protein mapped	2(1/1)
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Literature-origin	1(1/0)
ITGB5	integrin, beta 5	Literature-origin	1(1/0)
FGF1	fibroblast growth factor 1 (acidic)	Literature-origin	1(1/0)
APC	adenomatous polyposis coli	Literature-origin; SNP mapped	1(1/0)
MAPK1	mitogen-activated protein kinase 1	Literature-origin	2(2/0)
FGF9	fibroblast growth factor 9 (glia-activating factor)	Literature-origin	1(1/0)
PFN2	profilin 2	Protein mapped	0(0/0)
F2	coagulation factor II (thrombin)	Protein mapped	0(0/0)
RDX	radixin	Literature-origin	1(1/0)
ACTN4	actinin, alpha 4	Protein mapped	0(0/0)
TIAM1	T-cell lymphoma invasion and metastasis 1	Literature-origin	1(1/0)
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	Literature-origin	1(1/0)
FGFR2	fibroblast growth factor receptor 2	Literature-origin	2(2/0)
CYFIP1	cytoplasmic FMR1 interacting protein 1	Protein mapped	0(0/0)
INS	insulin	Literature-origin; Protein mapped	1(1/0)
BDKRB2	bradykinin receptor B2	SNP mapped	0(0/0)
FGFR3	fibroblast growth factor receptor 3	Literature-origin	2(2/0)
FGF2	fibroblast growth factor 2 (basic)	Literature-origin	2(2/0)
BDKRB1	bradykinin receptor B1	Protein mapped	0(0/0)
FGFR1	fibroblast growth factor receptor 1	Literature-origin	3(3/0)
RRAS2	related RAS viral (r-ras) oncogene homolog 2	Literature-origin	1(1/0)
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	Protein mapped	0(0/0)
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	Protein mapped	0(0/0)
PFN1	profilin 1	Protein mapped	0(0/0)