MK4MDD

Brain Morphology and Function Report

Basic Information
Name White matter
Brain Morphology "White matter is one of the two components of the central nervous system and consists mostly of myelinated axons. White matter tissue of the freshly cut brain appears pinkish white to the naked eye because myelin is composed largely of lipid tissue veined with capillaries. Its white color is due to its usual preservation in formaldehyde. A 20 year-old male has around 176,000 km of myelinated axons in his brain."
No. of Studies (Positive/Negative) 42(42/0) Help

Positive relationships between White matter and MDD (count: 31)
Name in Literature Reference Research Type Statistical Result Relation Description Help
white matter Alexopoulos, 2009 patients only Depressed elders (N=27) had lower FA (fractional anisotropy)...... Depressed elders (N=27) had lower FA (fractional anisotropy) than controls (N=27) in several frontolimbic areas. More...
frontal white matter Kumar, 2002 patients and normal controls myo-Inositol/creatine and choline/creatine ratios were signi...... myo-Inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. More...
hippocampal white matter fibers Frodl, 2002 patients and normal controls Both male and female patients showed significant alterations...... Both male and female patients showed significant alterations of left-right asymmetry and significant reductions of left and right hippocampal white matter fibers in relation to healthy comparison subjects. More...
white matter hyperintensities Nebes, 2002 patients and normal controls exceeded the 95% Confidence Intervals (CI) The individual who became depressed during the followup show...... The individual who became depressed during the followup showed an increase in WMH (white matter hyperintensities) volume that exceeded the 95% Confidence Intervals (CI) for change in the comparison group. More...
white matter Tupler, 2002 patients and normal controls Late-onset depressed patients had more severe hyperintensity...... Late-onset depressed patients had more severe hyperintensity ratings in deep white matter than early-onset patients and controls. More...
frontal white matter Steingard, 2002 patients and normal controls Significantly smaller frontal white matter volumes were foun...... Significantly smaller frontal white matter volumes were found in the depressed subjects, after controlling for age and whole brain volume. More...
white matter hyperintensities (WMH) Taylor, 2003 patients only P-value = .01 The depressed subgroup that achieved and sustained remission...... The depressed subgroup that achieved and sustained remission had significantly less increases in WMH volume (11.5%) than did the group that did not achieve or sustain remission (31.6%) (P =.01). More...
white matter Ballmaier, 2004 patients and normal controls Depressed patients also exhibited significant bilateral whit...... Depressed patients also exhibited significant bilateral white matter volume reductions and significant CSF volume increases in the anterior cingulate and the gyrus rectus. More...
occipital white matter Kumar, 2004 patients and normal controls Patients had significantly lower MTRs(Magnetization transfer...... Patients had significantly lower MTRs(Magnetization transfer ratios) in the genu and splenium of the corpus callosum, the right caudate nucleus and putamen, and the occipital white matter compared with controls. More...
white matter hyperintensities (WMH) Lin, 2005 patients and normal controls P-value = 0.024 Relative to control subjects, patients with late-life major ...... Relative to control subjects, patients with late-life major depressive disorder showed more severe brain atrophy (p = 0.043) and white matter hyperintensities (p = 0.024), especially in the periventricular area (p = 0.012). More...
white matter hyperintensities (WMH) Iosifescu, 2005 patients and normal controls Hypofolatemic and hypertensive patients had more severe WMHs...... Hypofolatemic and hypertensive patients had more severe WMHs than normal controls. More...
white matter lesion volume MacFall, 2006 patients and normal controls subjects with depression exhibited significantly greater tot...... subjects with depression exhibited significantly greater total white matter lesion volume in both hemispheres and in both frontal lobes than did control subjects More...
white matter hyperintensities (WMH) Iosifescu, 2007 patients only MDD with anger attacks was associated with higher severity o...... MDD with anger attacks was associated with higher severity of subcortical WMH and of total WMH. More...
white matter Ma, 2007 patients and normal controls The patient group exhibited significantly lower fractional a...... The patient group exhibited significantly lower fractional anisotropy values than healthy comparison subjects in the white matter of the right middle frontal gyrus, the left lateral occipitotemporal gyrus, and the subgyral and angular gyri of the right parietal lobe. More...
white matter Li, 2007 patients and normal controls Compared with healthy controls, patients with MDD showed sig...... Compared with healthy controls, patients with MDD showed significantly lower fractional anisotropy (FA) values in prefrontal white matter at bilateral 20 mm, right 16 mm and right 12 mm above the AC-PC(anterior commissure-posterior commissure). More...
white matter Chen, 2009 patients and normal controls The biochemical abnormalities in late-life major depressive ...... The biochemical abnormalities in late-life major depressive disorder were found on the left side of the frontal white matter. More...
white matter Kieseppa, 2010 patients and normal controls Compared with controls, the MDD patients showed a trend for ...... Compared with controls, the MDD patients showed a trend for lower values of fractional anisotropy (FA) in the left sagittal stratum, and suggestive decreased FA in the right cingulate cortex and posterior body of corpus callosum. A novel observer-independent DTI method showed decreased FA in the middle-aged MDD patients in white matter regions More...
hippocampal white matter Frodl, 2010 patients and normal controls Significantly smaller hippocampal white matter and prefronta...... Significantly smaller hippocampal white matter and prefrontal gray matter volume was observed in patients with MD compared to healthy controls. More...
white matter (WM) Cullen, 2010 patients and normal controls Adolescents with MDD demonstrated lower fractional anisotrop...... Adolescents with MDD demonstrated lower fractional anisotropy (FA) in the WM tract connecting subgenual ACC to amygdala in the right hemisphere. 10 clusters where adolescents with MDD had significantly lower (uncorrected) FA than the healthy group within WM tracts including right and left uncinate and supragenual cingulum. More...
white matter Hwang, 2010 patients and normal controls Late-onset depression was associated with smaller volumes in...... Late-onset depression was associated with smaller volumes in several regions of white matter (subcallosal cingulate cortex, floor of lateral ventricles, parahippocampal region, insula, and the cerebellum). More...
white matter Dalby, 2010 patients and normal controls We showed a significant positive association between depress...... We showed a significant positive association between depression severity and fiber tracts intersected by WMLs (white matter lesions) in the left superior longitudinal fasciculus and the right uncinate fasciculus. More...
white matter Huang, 2011 high-risk people and normal controls Adolescents at high risk for unipolar depression had lower f...... Adolescents at high risk for unipolar depression had lower fractional anisotropy (FA) values in the left cingulum, splenium of the corpus callosum, superior longitudinal fasciculi, uncinate, and inferior fronto-occipital fasciculi than did controls. Altered white matter integrity in healthy adolescents at familial risk for unipolar depression suggests that it might serve as a vulnerability marker for the illness. More...
prefrontal white matter Blood, 2010 patients and normal controls Fractional anisotropy (FA) values were reduced in dorsolater...... Fractional anisotropy (FA) values were reduced in dorsolateral prefrontal white matter in MDD subjects. More...
white matter Wu, 2011 patients and normal controls Fractional anisotropy was significantly lower and apparent d...... Fractional anisotropy was significantly lower and apparent diffusion coefficient was significantly higher in the right superior longitudinal fasciculus (SLF) within the frontal lobe, right middle frontal and left parietal white matter in the MDD group compared with the healthy group. More...
white matter Korgaonkar, 2010 patients and normal controls Significant WM (white matter) integrity deficits were seen o...... Significant WM (white matter) integrity deficits were seen only for the melancholic MDD participants compared with controls. More...
white matter Aizenstein, 2011 patients and normal controls The depressed group showed a significantly greater interacti...... The depressed group showed a significantly greater interaction of white matter hyperintensity (WMH) by fMRI activity effect than the nondepressed group. More...
white matter Gabbay, 2012 patients and normal controls P-value = 0.04 Anterior cingulate cortex white matter was also significantl...... Anterior cingulate cortex white matter was also significantly decreased in adolescents with MDD compared with controls (P = .04). More...
inferior fronto-occipital fasciculus Frodl, 2012 high-risk people and normal controls The unaffected first-degree healthy relatives (UHRs) showed ...... The unaffected first-degree healthy relatives (UHRs) showed greater fractional anisotropy than controls in the inferior fronto-occipital fasciculus (IFO), More...
right fornix Frodl, 2012 high-risk people and normal controls The unaffected first-degree healthy relatives (UHRs) showed ...... The unaffected first-degree healthy relatives (UHRs) showed greater fractional anisotropy than controls in the right fornix. More...
fractional anisotropy Zhang, 2012 patients and normal controls P-value < 0.05 Significantly decreased fractional anisotropy (FA) and incre...... Significantly decreased fractional anisotropy (FA) and increased radial diffusivity of the right UF were observed in MDD patients compared with HC (p<0.05) More...
uncinate fasciculus Zhang, 2012 patients and normal controls r=-0.53, P-value = 0.02 Significantly decreased fractional anisotropy (FA) and incre...... Significantly decreased fractional anisotropy (FA) and increased radial diffusivity of the right UF were observed in MDD patients compared with HC (p<0.05). Among MDD subjects, depression severity had a significant negative correlation with normalized number of fibers (NNF) in the right UF (r=-0.53, p=0.02). More...

Positive relationships between White matter and other components at different levels (count: 16) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of White matter in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between White matter and MDD (count: 0)
Negative relationships between White matter and other components at different levels (count: 0) Help