Symptoms Report

Name	Feelings of hopelessness, worthlessness, and guilt
Description	Depressed people may be preoccupied with, or ruminate over, thoughts and feelings of worthlessness, inappropriate guilt or regret, helplessness, hopelessness, and self-hatred.
No. of Studies (Positive/Negative)	13 (13/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
feelings of worthlessness	Wilcox, 2004	patients and normal controls		The earliest and most frequently occurring forerunners of ad...... The earliest and most frequently occurring forerunners of adult-onset MDD were persistent depressed mood, anhedonia, feelings of worthlessness, and thoughts of death or suicide, with persistent anhedonia and worthlessness having a special prognostic value. More...
felt more helpless	Diener, 2009	patients and normal controls		Depressed participants also felt more helpless than controls...... Depressed participants also felt more helpless than controls. More...
sense of failure, dissatisfaction, and self-dislike	Pasquini, 2008	patients only	P-value <.0001	Sense of failure, dissatisfaction, and self-dislike were hig...... Sense of failure, dissatisfaction, and self-dislike were higher among MDD patients than among IFN-alpha patients (P<.0001). More...
sense of guilt	Pasquini, 2008	patients only	P-value <.0001	Sense of guilt was higher among MDD patients (56.5%) and was...... Sense of guilt was higher among MDD patients (56.5%) and was lower among cancer patients (4%) (P<.0001). More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
helplessness		HTR1B(5-HT(1B))	gene	McDevitt, 2011	animal model		The 5-HT(1B) autoreceptors originating in the caudal DRN reg...... The 5-HT(1B) autoreceptors originating in the caudal DRN regulate behavioral expression of helplessness and fear.Overexpression of 5-HT(1B) in the caudal DRN increased swimming in the forced swim test. More...
feeling of guilt		Slow wave potential(temporal slow waves)	neurobiological system	Motomura, 2002	patients and normal controls	P-value <0.01	each score of HAMD in patients with temporal slow waves show...... each score of HAMD in patients with temporal slow waves showed a significantly lower score for feeling of guilt (P<0.01) More...
hopelessness		Posterior cingulate cortex(posterior cingulate cortex)	brain morphology and function	Grimm, 2009	patients and normal controls		MDD patients showed significantly reduced NBRs (negative blo...... MDD patients showed significantly reduced NBRs (negative blood oxygenation level-dependent responses) in several regions of the default-mode network such as the pregenual anterior cingulate cortex, the ventromedial prefrontal cortex, and the posterior cingulate cortex. Decreased NBRs in MDD patients correlated with depression severity and feelings of hopelessness. More...
hopelessness		pregenual anterior cingulate cortex(pregenual anterior cingulate cortex)	brain morphology and function	Grimm, 2009	patients and normal controls		MDD patients showed significantly reduced NBRs (negative blo...... MDD patients showed significantly reduced NBRs (negative blood oxygenation level-dependent responses) in several regions of the default-mode network such as the pregenual anterior cingulate cortex, the ventromedial prefrontal cortex, and the posterior cingulate cortex. Decreased NBRs in MDD patients correlated with depression severity and feelings of hopelessness. More...
hopelessness		ventromedial prefrontal cortex(ventromedial prefrontal cortex)	brain morphology and function	Grimm, 2009	patients and normal controls		MDD patients showed significantly reduced NBRs (negative blo...... MDD patients showed significantly reduced NBRs (negative blood oxygenation level-dependent responses) in several regions of the default-mode network such as the pregenual anterior cingulate cortex, the ventromedial prefrontal cortex, and the posterior cingulate cortex. Decreased NBRs in MDD patients correlated with depression severity and feelings of hopelessness. More...
hopelessness		right insula(right insula)	brain morphology and function	Yao, 2009	patients and normal controls		Hopelessness severity was positively correlated with the ReH...... Hopelessness severity was positively correlated with the ReHo (regional homogeneity) in the right ventral anterior cingulate gyrus and the right insula. More...
hopelessness		right ventral anterior cingulate gyrus(right ventral anterior cingulate gyrus)	brain morphology and function	Yao, 2009	patients and normal controls		Hopelessness severity was positively correlated with the ReH...... Hopelessness severity was positively correlated with the ReHo (regional homogeneity) in the right ventral anterior cingulate gyrus and the right insula. More...
hopelessness		dorsomedial prefrontal cortex (DMPFC)(dorsomedial prefrontal cortex (DMPFC))	brain morphology and function	Grimm, 2009	patients and normal controls		Signal changes in the DMPFC correlated with depression sever...... Signal changes in the DMPFC correlated with depression severity and hopelessness. More...
helplessness		Dorsal raphe nucleus(dorsal raphe nucleus)	brain morphology and function	McDevitt, 2011	animal model		The 5-HT(1B) autoreceptors originating in the caudal DRN reg...... The 5-HT(1B) autoreceptors originating in the caudal DRN regulate behavioral expression of helplessness and fear.Overexpression of 5-HT(1B) in the caudal DRN increased swimming in the forced swim test. More...
hopelessness		Attribution and attitude(higher ratings of self-relatedness)	cognition and behavior	Grimm, 2011	patients and normal controls		Behaviourally, MDD subjects showed significantly higher rati...... Behaviourally, MDD subjects showed significantly higher ratings of self-relatedness that also correlated with depression symptoms such as hopelessness. More...
hopeless		Suicide(suicide intent)	symptoms	Horesh, 2003	patients only		Suicidal versus nonsuicidal adolescents were more depressed,...... Suicidal versus nonsuicidal adolescents were more depressed, hopeless, and aggressive, but not more angry or impulsive. More...
hopelessness		Suicide(suicide intent)	symptoms	Barbe, 2005	patients only	P-value = .001	Depressed suicidal youth were more hopeless (p = .001). Amon...... Depressed suicidal youth were more hopeless (p = .001). Among postpubertal depressed females, suicidal girls were more frequently hopeless (p = .008). More...
feelings of worthlessness		Suicide(suicidal behavior)	symptoms	Liu, 2006	patients only		Only feelings of worthlessness was related to all 4 suicidal...... Only feelings of worthlessness was related to all 4 suicidal behaviors, after adjustment for other depressive symptoms, comorbid disorders, and demographics. Feelings of worthlessness may play a central role in the development of suicidal behavior. More...
helplessness		Stress(stress)	environment	Garcia-Garcia AL, 2009	animal model		CMS induced anhedonia, helplessness, anxiety, and impaired r...... CMS induced anhedonia, helplessness, anxiety, and impaired recognition memory More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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