MK4MDD

Pathway Report

Basic Information
Name Cell adhesion molecules
KEGG Link ID: hsa04514
Name: cell adhesion_molecules_cams
Brief Description: Cell adhesion molecules (CAMs)
Full Description: Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cellcell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
No. of Studies (Positive/Negative) 2 (2/0) Help

Positive relationship between Cell adhesion molecules and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
cell adhesion molecules Thomas, 2002 patients and normal controls We found significant increases in CAMs in the grey matter of...... We found significant increases in CAMs in the grey matter of the DLPFC in the depression group but no comparable differences in the ACC or occipital cortex. More...
Cell adhesion molecules Kao CF, 2012 patients and normal controls We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

Positive relationships between Cell adhesion molecules and other components at different levels (count: 0) Help
Positive relationship network of Cell adhesion molecules in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Cell adhesion molecules and MDD (count: 0)
Negative relationships between Cell adhesion molecules and other components at different levels (count: 0) Help
Pathway Cell adhesion molecules related genes in MK4MDD (count: 19)