MK4MDD

Brain Morphology and Function Report

Basic Information
Name Caudate nucleus
Brain Morphology "The caudate nuclei are located near the center of the brain, sitting astride the thalamus. There is a caudate nucleus within each hemisphere of the brain. Individually, they resemble a C-shape structure with a wider ""head"" at the front, tapering to a ""body"" (corpus) and a ""tail"" (cauda). Sometimes a part of the caudate nucleus is referred to as the ""knee"" (genu). Together the caudate and putamen form the dorsal striatum."
Brain Function The caudate nucleus is an important part of the brain's learning and memory system. Its function also includes language comprehension and threshold control.
Picture Caudate nucleus Source Magnify
No. of Studies (Positive/Negative) 29(29/0) Help

Positive relationships between Caudate nucleus and MDD (count: 13)
Name in Literature Reference Research Type Statistical Result Relation Description Help
caudate Forbes, 2009 patients and normal controls Diminished activation in a caudate region associated with th...... Diminished activation in a caudate region associated with this depression group difference was correlated with lower subjective positive affect in natural environments, particularly within the depressed group More...
caudate Pizzagalli, 2009 patients and normal controls Relative to comparison subjects, participants with major dep...... Relative to comparison subjects, participants with major depression showed significantly weaker responses to gains in the caudate bilaterally. More...
caudate nucleus McCabe, 2009 patients and normal controls Patients showed increases in the caudate nucleus to the aver...... Patients showed increases in the caudate nucleus to the aversive stimulus. More...
caudate nucleus Awata, 1998 patients and normal controls (patients with major depressive disorder in late life) compa...... (patients with major depressive disorder in late life) compared with 13 age-matched controls, relative rCBF(regional cerebral blood flow) was significantly decreased bilaterally in the caudate nucleus. More...
caudate Vythilingam, 2003 patients and normal controls Compared with control subjects, MDD patients had a significa...... Compared with control subjects, MDD patients had a significantly lower mean NAA/Cr amplitude in the caudate and a significantly higher mean Cho/Cr amplitude in the putamen, particularly on the right side. More...
caudate Lee, 2008 patients and normal controls When shown pictures of sad faces, patients with MDD relative...... When shown pictures of sad faces, patients with MDD relative controls showed decreased activations bilaterally in the caudate. More...
caudate Selvaraj, 2011 patients and normal controls The depressed patients had lowered 5-HTT binding in several ...... The depressed patients had lowered 5-HTT binding in several brain regions including caudate More...
bilateral caudate Bluhm, 2009 patients and normal controls Direct comparison showed significantly reduced correlation b...... Direct comparison showed significantly reduced correlation between the P/PCC(precuneus/posterior cingulate cortex) and the bilateral caudate in depression compared with controls and no areas of increased connectivity in the depressed group. More...
caudate nucleus Scheuerecker, 2010 patients and normal controls Depressed patients showed increased activity during emotion ...... Depressed patients showed increased activity during emotion recognition in the caudate nucleus. More...
caudate nucleus Khundakar, 2011 patients and normal controls Evidence of moderate reductions in neuronal density was foun...... Evidence of moderate reductions in neuronal density was found in the depressed group in both the dorsolateral and ventromedial areas of the caudate nucleus. More...
caudate Ritchey, 2011 patients and normal controls Prior to treatment and relative to controls, patients exhibi...... Prior to treatment and relative to controls, patients exhibited diminished discrimination between emotional and neutral items in the amygdala, caudate, and hippocampus. More...
caudate nucleus Zhang, 2011 patients and normal controls The MDD patients exhibited increased nodal centralities, pre...... The MDD patients exhibited increased nodal centralities, predominately in the caudate nucleus. More...
caudate nucleus Levesque, 2011 high-risk people In children whose mothers exhibited higher depressive sympto...... In children whose mothers exhibited higher depressive symptomatology, compared to children whose mothers displayed lower depressive symptomatology, altered neural responses to sad film excerpts were noted in brain regions known to be involved in sadness and MD, notably the insula, anterior cingulate cortex and caudate nucleus, even though the children did not differ in current mood. More...

Positive relationships between Caudate nucleus and other components at different levels (count: 21) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Caudate nucleus in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Caudate nucleus and MDD (count: 0)
Negative relationships between Caudate nucleus and other components at different levels (count: 0) Help