Protein Report

Protein Name	Brain-derived neurotrophic factor
UniPortKB	P23560
No. of Studies (Positive/Negative)	20 (19/1)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
BDNF	Lee, 2007	patients and normal controls	P-value<0.001	Plasma BDNF levels were significantly lower in MDD patients ...... Plasma BDNF levels were significantly lower in MDD patients than in normal control subjects (p<0.001). More...
BDNF	Deveci, 2007	patients and normal controls	P-value = 0.004	Mean serum BDNF levels were significantly lower in the suici...... Mean serum BDNF levels were significantly lower in the suicide group (21.2 +/- 12.4 ng/ml) and the major depressive disorder group (21.2 +/- 11.3 ng/ml) than the control group (31.4 +/- 8.8 ng/ml; p = 0.004). More...
BDNF	Grassi-Oliveira, 2008	patients and normal controls	P-value<0.001	Major depressive disorder patients showed lower plasma BDNF ...... Major depressive disorder patients showed lower plasma BDNF concentrations than healthy control subjects (p < .001). More...
BDNF	Dunham, 2009	patients and normal controls		In MDD, reductions in (pro)BDNF were seen in all layers of t...... In MDD, reductions in (pro)BDNF were seen in all layers of the right but not the left hippocampus with no changes in the dentate gyrus More...
BDNF	Ozan, 2010	patients and normal controls	P-value<0.0001	Patients had a lower serum BDNF level than healthy subjects ...... Patients had a lower serum BDNF level than healthy subjects (22.47 vs. 27.49; p<0.0001). More...
brain-derived neurotrophic factor (BDNF)	Shi, 2010	patients and normal controls	P-value = 0.037	Baseline plasma BDNF and tPA levels were significantly lower...... Baseline plasma BDNF and tPA levels were significantly lower in LGD(late-onset geriatric depression) patients compared to controls (P = 0.037 and P = 0.000, respectively). There was a heightening tendency of plasma BDNF level after treatment. More...
BDNF	Dell'Osso, 2010	patients only		BDNF plasma levels were significantly lower in the patients ...... BDNF plasma levels were significantly lower in the patients with the severest illness compared with the others More...
BDNF	Yoshimura, 2010	patients and normal controls		The serum BDNF levels in patients with dysthymic and major d...... The serum BDNF levels in patients with dysthymic and major depressive disorder were significantly lower than those in the control subjects More...
brain-derived neurotrophic factor	Chu CL, 2011	patients and normal controls	P-value<0.001	We found that plasma BDNF was significantly lower in the maj...... We found that plasma BDNF was significantly lower in the major depressive group (mean, 115.1 pg/mL; SD, 57.2) than in the nondepressive group (mean, 548.8 pg/mL; SD, 370.6; P < .001). The BDNF plasma concentrations in the subclinically depressive group (mean, 231.8 pg/mL; SD, 92.4; P < .001) and control group were also significantly different. More...
Glial cell-line derived neurotrophic factor	Diniz BS, 2012	patients and normal controls	P-value < 0.001	Patients with major depression showed a significant reducti...... Patients with major depression showed a significant reduction in GDNF levels as compared to healthy elderly controls (p < 0.001) More...
BDNF	Hasselbalch BJ, 2012	patients and normal controls		patients with unipolar depressive disorder had decreased lev...... patients with unipolar depressive disorder had decreased levels of BDNF compared to healthy control individuals [B = -7.4, 95% CI (-11.2, -3.7), = 0.21 P < 0.001]. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
BDNF		Cyclic AMP-responsive element-binding protein 1(CREB)	protein	Schmidt HD, 2010	animal model		Expression of pCREB and pERK were elevated in the hippocampu...... Expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF More...
BDNF		Glial fibrillary acidic protein(glial fibrillary acidic protein)	protein	Ye Y, 2011	animal model		CUMS produced decreased glial fibrillary acidic protein (GFA...... CUMS produced decreased glial fibrillary acidic protein (GFAP) expression and increased s100 calcium binding protein b (s100b) expression in rat hippocampus, which were partially rescued by BDNF administration More...
BDNF		Protein S100-B(s100 calcium binding protein b)	protein	Ye Y, 2011	animal model		CUMS produced decreased glial fibrillary acidic protein (GFA...... CUMS produced decreased glial fibrillary acidic protein (GFAP) expression and increased s100 calcium binding protein b (s100b) expression in rat hippocampus, which were partially rescued by BDNF administration More...
brain-derived neurotrophic factor (BDNF)		Paroxetine(paroxetine)	molecule	Yasui-Furukori, 2011	patients only	P-value < 0.05	Changes in plasma BDNF level were correlated with plasma dru...... Changes in plasma BDNF level were correlated with plasma drug concentration after 2 (r = 0.309, p < 0.05) and 6 weeks (r = 0.329, p < 0.05) but not correlated with plasma drug concentration after 1 week (r = 0.284, ns). More...
BDNF		mapkkk cascade(ERK)	pathway	Schmidt HD, 2010	animal model		Expression of pCREB and pERK were elevated in the hippocampu...... Expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF More...
BDNF		Hippocampus(hippocampal volumes)	brain morphology and function	Eker, 2010	patients and normal controls	P-value = 0.02	sBDNF levels and hippocampal volumes correlated only in the ...... sBDNF levels and hippocampal volumes correlated only in the MDD group (right: r = 0.46, P = 0.02; left: r = 0.47, P = 0.02) More...
BDNF		Hippocampus(hippocampus)	brain morphology and function	Schmidt HD, 2010	animal model		Adult hippocampal neurogenesis was increased after chronic, ...... Adult hippocampal neurogenesis was increased after chronic, peripheral BDNF administration More...
BDNF		Hippocampus(hippocampus)	brain morphology and function	Ye Y, 2011	animal model		CUMS produced decreased glial fibrillary acidic protein (GFA...... CUMS produced decreased glial fibrillary acidic protein (GFAP) expression and increased s100 calcium binding protein b (s100b) expression in rat hippocampus, which were partially rescued by BDNF administration More...
BDNF		Memory(memory performance)	cognition and behavior	Grassi-Oliveira, 2008	patients and normal controls		Brain-derived neurotrophic factor levels were negatively rel...... Brain-derived neurotrophic factor levels were negatively related to psychological morbidity and positively correlated to memory performance. Regression models showed that severity of self-reported CPN(childhood physical neglect) and low plasma BDNF predicted impairment on immediate verbal recall More...
BDNF		Anxiety-like behaviors from animal model(anxiety-like behavior)	cognition and behavior	Schmidt HD, 2010	animal model		Peripheral BDNF administration increased mobility in the FST...... Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM More...
BDNF		Depression-like behaviors from animal model(depressive-like behavior)	cognition and behavior	Schmidt HD, 2010	animal model		Peripheral BDNF administration increased mobility in the FST...... Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM More...
BDNF		anhedonic-like behavior from animal model(anhedonic-like behavior)	cognition and behavior	Schmidt HD, 2010	animal model		Peripheral BDNF administration increased mobility in the FST...... Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM More...
BDNF		anhedonic-like behavior from animal model(anhedonic-like behavior)	cognition and behavior	Ye Y, 2011	animal model		Results revealed that CUMS induced anhedonic-like behaviors ...... Results revealed that CUMS induced anhedonic-like behaviors in sucrose consumption and open field performances, which were partially reversed by BDNF infusion More...
brain-derived neurotropic factor (BDNF)		Depressed mood(depressed mood)	symptoms	Yukimasa, 2006	patients only		In addition, the plasma levels of BDNF were significantly in...... In addition, the plasma levels of BDNF were significantly increased by 23 % in responders and partial responders, but not in nonresponders, after rTMS treatment, and a trend for association was found between the changes in Ham-D scores and changes in plasma BDNF levels in all patients after rTMS treatment. More...
BDNF		Suicide(suicide attempt)	symptoms	Kim, 2007	patients and normal controls	F=6.682, P-value=0.002	Plasma BDNF levels were measured by enzyme linked immunosorb...... Plasma BDNF levels were measured by enzyme linked immunosorbent assay. BDNF levels were significantly lower in suicidal MDD patients (430.5+/-397.0 pg/ml) than non-suicidal MDD patients (875.80+/-663.02 pg/ml) or normal controls (889.4+/-611.3 pg/ml) (F=6.682, p=0.002). More...
BDNF		Suicide(suicide attempt)	symptoms	Deveci, 2007	patients and normal controls	P-value = 0.004	Mean serum BDNF levels were significantly lower in the suici...... Mean serum BDNF levels were significantly lower in the suicide group (21.2 +/- 12.4 ng/ml) and the major depressive disorder group (21.2 +/- 11.3 ng/ml) than the control group (31.4 +/- 8.8 ng/ml; p = 0.004). More...
BDNF		Child abuse(childhood physical neglect)	environment	Grassi-Oliveira, 2008	patients and normal controls	P-value<0.05	Major depressive disorder + CPN(childhood physical neglect) ...... Major depressive disorder + CPN(childhood physical neglect) had even lower BDNF levels compared with control subjects and MDD (p < .05). More...
Brain-derived neurotrophic factor (BDNF)		Physical exercise(exercise)	environment	Gustafsson, 2009	patients and normal controls		BDNF increased significantly during exercise in both male an...... BDNF increased significantly during exercise in both male and female patients as well as in male controls, with no significant differences between the groups. BDNF levels declined after exercise, but after 60 min of rest BDNF levels showed tendencies to increase again in male patients More...
BDNF		Child abuse(childhood abuse)	environment	Elzinga, 2011	patients only	P-value = 1.7 ¡Á 10(-7)	Overall, BDNF Met carriers had reduced serum BDNF levels whe...... Overall, BDNF Met carriers had reduced serum BDNF levels when exposed to CA in a dose-dependent way. More...
BDNF		Life events(recent life events)	environment	Elzinga, 2011	patients only		Exposure to recent life events was associated with decreases...... Exposure to recent life events was associated with decreases in BDNF levels More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
BDNF		anhedonic-like behavior from animal model(anhedonic-like behavior)	cognition and behavior	Lucca G, 2008	animal model		BDNF protein levels were not significantly correlated with t...... BDNF protein levels were not significantly correlated with the decrease of sweet food consumption observed in CMS exposed animals More...

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
BDNF	brain-derived neurotrophic factor	Literature-origin; SNP mapped; Protein mapped	23 (17/6)