|Citation||Eker, 2010 PubMed
|Full Info||Eker, C., Kitis, O., Taneli, F., Eker, O.D., Ozan, E., Yucel, K., Coburn, K. and Gonul, A.S. (2010) Correlation of serum BDNF levels with hippocampal volumes in first episode, medication-free depressed patients. Eur Arch Psychiatry Clin Neurosci, 260, 527-533.
|Hypothesis or Background
The hippocampus seems to be affected in MDD, and brain-derived neurotrophic factor (BDNF) has positive effects on neurogenesis within the hippocampus. Although there are inconsistencies among study results, a smaller hippocampal volume in depressed patients is thought to be related to the pathophysiology of the disease.
|Sample Information||first-episode MDD patients (18 female, 7 male; mean age = 32.1 +/- 9.3) and healthy controls (17 female, 5 male; mean age = 29.7 +/- 6.4)|
|Method Detail||We looked at the correlation between serum BDNF (sBDNF) levels and hippocampal volumes (HCV) of first-episode MDD patients and healthy controls. Region of interest analysis was conducted on the images acquired via MRI.
|Method Keywords||magnetic resonance imaging (MRI); blood analysis
|Result||sBDNF levels and HCV correlated only in the MDD group (right: r = 0.46, P = 0.02; left: r = 0.47, P = 0.02); however, HCV did not differ between MDD patients and healthy controls (right: F = 2.45, df = 1.46, P > 0.05; left: F = 0.05, df = 1.46, P > 0.05)
|Conclusions||BDNF may be a factor underlying HCV differences between MDD and healthy control subjects, which become apparent as severe and multiple episodes are experienced.
Relationships reported by Eker, 2010