MK4MDD

Protein Report

Basic Information
Protein Name Brain-derived neurotrophic factor
UniPortKB P23560
No. of Studies (Positive/Negative) 22 (21/1) Help
Type Literature-origin
Positive relationship between Brain-derived neurotrophic factor and MDD (count: 12)
Name in Literature Reference Research Type Statistical Result Relation Description Help
BDNF Lee, 2007 patients and normal controls P-value<0.001 Plasma BDNF levels were significantly lower in MDD patients ...... Plasma BDNF levels were significantly lower in MDD patients than in normal control subjects (p<0.001). More...
BDNF Deveci, 2007 patients and normal controls P-value = 0.004 Mean serum BDNF levels were significantly lower in the suici...... Mean serum BDNF levels were significantly lower in the suicide group (21.2 +/- 12.4 ng/ml) and the major depressive disorder group (21.2 +/- 11.3 ng/ml) than the control group (31.4 +/- 8.8 ng/ml; p = 0.004). More...
BDNF Grassi-Oliveira, 2008 patients and normal controls P-value<0.001 Major depressive disorder patients showed lower plasma BDNF ...... Major depressive disorder patients showed lower plasma BDNF concentrations than healthy control subjects (p < .001). More...
BDNF Dunham, 2009 patients and normal controls In MDD, reductions in (pro)BDNF were seen in all layers of t...... In MDD, reductions in (pro)BDNF were seen in all layers of the right but not the left hippocampus with no changes in the dentate gyrus More...
BDNF Ozan, 2010 patients and normal controls P-value<0.0001 Patients had a lower serum BDNF level than healthy subjects ...... Patients had a lower serum BDNF level than healthy subjects (22.47 vs. 27.49; p<0.0001). More...
brain-derived neurotrophic factor (BDNF) Shi, 2010 patients and normal controls P-value = 0.037 Baseline plasma BDNF and tPA levels were significantly lower...... Baseline plasma BDNF and tPA levels were significantly lower in LGD(late-onset geriatric depression) patients compared to controls (P = 0.037 and P = 0.000, respectively). There was a heightening tendency of plasma BDNF level after treatment. More...
BDNF Dell'Osso, 2010 patients only BDNF plasma levels were significantly lower in the patients ...... BDNF plasma levels were significantly lower in the patients with the severest illness compared with the others More...
BDNF Yoshimura, 2010 patients and normal controls The serum BDNF levels in patients with dysthymic and major d...... The serum BDNF levels in patients with dysthymic and major depressive disorder were significantly lower than those in the control subjects More...
brain-derived neurotrophic factor Chu CL, 2011 patients and normal controls P-value<0.001 We found that plasma BDNF was significantly lower in the maj...... We found that plasma BDNF was significantly lower in the major depressive group (mean, 115.1 pg/mL; SD, 57.2) than in the nondepressive group (mean, 548.8 pg/mL; SD, 370.6; P < .001). The BDNF plasma concentrations in the subclinically depressive group (mean, 231.8 pg/mL; SD, 92.4; P < .001) and control group were also significantly different. More...
Glial cell-line derived neurotrophic factor Diniz BS, 2012 patients and normal controls P-value < 0.001 Patients with major depression showed a significant reducti...... Patients with major depression showed a significant reduction in GDNF levels as compared to healthy elderly controls (p < 0.001) More...
BDNF Hasselbalch BJ, 2012 patients and normal controls patients with unipolar depressive disorder had decreased lev...... patients with unipolar depressive disorder had decreased levels of BDNF compared to healthy control individuals [B = -7.4, 95% CI (-11.2, -3.7), = 0.21 P < 0.001]. More...
BDNF Zhou L, 2013 patients and normal controls the protein and serum levels of proBDNF, sortilin and p75NTR...... the protein and serum levels of proBDNF, sortilin and p75NTR were higher in major depressive patients than in healthy controls while mature BDNF and TrkB levels were lower More...

Positive relationships between Brain-derived neurotrophic factor and other components at different levels (count: 21) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Positive relationship network of Brain-derived neurotrophic factor in MK4MDD
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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Brain-derived neurotrophic factor and MDD (count: 0)
Negative relationships between Brain-derived neurotrophic factor and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
BDNF brain-derived neurotrophic factor Literature-origin; SNP mapped; Protein mapped 28 (19/9)