MK4MDD

Brain Morphology and Function Report

Basic Information
Name Basal ganglia
Brain Morphology "The basal ganglia are a group of nuclei of varied origin in the brains of vertebrates that act as a cohesive functional unit. They are situated at the base of the forebrain and strongly connected with the cerebral cortex, thalamus and other brain areas. The main components of the basal ganglia are the striatum (also called neostriatum) composed of caudate and putamen, globus pallidus or pallidum composed of globus pallidus externa (GPe) and globus pallidus interna (GPi), substantia nigra composed of both substantia nigra pars compacta (SNc) and substantia nigra pars reticulata (SNr), and the subthalamic nucleus (STN)."
Brain Function "The basal ganglia are associated with a variety of functions, including voluntary motor control, procedural learning relating to routine behaviors or ""habits"" such as bruxism, eye movements, and cognitive, emotional functions. Currently popular theories implicate the basal ganglia primarily in action selection, that is, the decision of which of several possible behaviors to execute at a given time. Experimental studies show that the basal ganglia exert an inhibitory influence on a number of motor systems, and that a release of this inhibition permits a motor system to become active. The ""behavior switching"" that takes place within the basal ganglia is influenced by signals from many parts of the brain, including the prefrontal cortex, which plays a key role in executive functions."
Picture Basal ganglia From Wiki. Magnify
No. of Studies (Positive/Negative) 12(12/0) Help

Positive relationships between Basal ganglia and MDD (count: 9)
Name in Literature Reference Research Type Statistical Result Relation Description Help
basal ganglia D'Haenen H, 1994 patients and normal controls Mann-Whitney U test P-value = 0.025; The mean basal ganglia/cerebellum uptake ratio was 1.94 (SD= 0.27) in the depressed patients versus 1.74 (SD= 0.17) in the controls. The basal ganglia/cerebellum 123I-iodobenzamide (a high-affi...... The basal ganglia/cerebellum 123I-iodobenzamide (a high-affinity ligand for D2 receptors) uptake ratio was higher in depressed patients than controls. More...
basal ganglia Videbech, 2002 patients and normal controls The patients had increased blood flow to the basal ganglia. The patients had increased blood flow to the basal ganglia.
basal ganglia Agid, 2003 patients and normal controls P-value = 0.004 Mean volume of T2-WIH was significantly greater (p=0.004) in...... Mean volume of T2-WIH was significantly greater (p=0.004) in depressed subjects. In the control group T2-WIH(T2-weighted image 'hyperintensities') were exclusively located in the supratentorial hemispheral white matter while in the depressed group T2-WIH were also found in basal ganglia, temporal lobe, cerebellum and brainstem. More...
basal ganglia structures Milak, 2005 patients only Total HDRS(Hamilton Depression Rating Scale) score correlate...... Total HDRS(Hamilton Depression Rating Scale) score correlated positively with activity in a large bilateral ventral cortical and subcortical region that included limbic, thalamic, and basal ganglia structures. More...
basal ganglia regions Perico, 2005 patients and normal controls Our findings confirmed the prediction that separate symptom ...... Our findings confirmed the prediction that separate symptom domains of the MDD syndrome are related to specific rCBF patterns, and extend results from prior studies that suggested the involvement of anterior cingulate, frontal, limbic and basal ganglia regions in the pathophysiology of MDD. More...
basal ganglia Fujimoto, 2008 patients only The 3D-SSP score map showed increased relative metabolism in...... The 3D-SSP score map showed increased relative metabolism in the basal ganglia in both hemispheres in patients compared with controls. More...
basal ganglia Chen, 2009 patients and normal controls The biochemical abnormalities in late-life major depressive ...... The biochemical abnormalities in late-life major depressive disorder were found on the basal ganglia. More...
basal ganglia Amico, 2011 patients and high-risk people and normal controls Patients with MDD exhibited smaller volumes in the basal gan...... Patients with MDD exhibited smaller volumes in the basal ganglia compared with healthy controls. More...
basal ganglia Kessler, 2011 patients and normal controls Relative to control subjects, patients with depression showe...... Relative to control subjects, patients with depression showed increased hemodynamic responses in limbic-paralimbic and subcortical regions (e.g. amygdala and basal ganglia) but no signal decrease in prefrontal regions. More...

Positive relationships between Basal ganglia and other components at different levels (count: 7) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Basal ganglia in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Basal ganglia and MDD (count: 0)
Negative relationships between Basal ganglia and other components at different levels (count: 0) Help