Protein Report

Basic Information

Protein Name	Tumor necrosis factor
UniPortKB	P01375
No. of Studies (Positive/Negative)	13 (10/3)
Type	Literature-origin

Positive relationship between Tumor necrosis factor and MDD (count: 7)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
TNF-alpha	Pavon, 2006	patients and normal controls		The MDD subjects showed higher levels of cortisol and TNF-al...... The MDD subjects showed higher levels of cortisol and TNF-alpha, More...
TNF-¦Á	Leo, 2006	patients and normal controls		Compared with control subjects, MDD patients had higher base...... Compared with control subjects, MDD patients had higher baseline levels of TNF-¦Á More...
tumor necrosis factor-alpha (TNF-alpha)	Kim, 2007	patients and normal controls		At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN...... At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN-gamma/IL-4 ratio were significantly higher in MDD patients. More...
TNF-¦Á	Piletz, 2010	patients and normal controls	P-value=0.04	Compared to controls, patients with MDD had significantly hi...... Compared to controls, patients with MDD had significantly higher baseline levels of tumour necrosis factor-alpha (TNFalpha, P=0.04) in the blood. More...
tumor necrosis factor-alpha (TNFalpha)	Eller, 2009	patients and normal controls		Tumor necrosis factor-alpha (TNFalpha) levels were higher in...... Tumor necrosis factor-alpha (TNFalpha) levels were higher in drug-nalve patients with major depressive disorder with recurrent episode compared with previously treated patients. More...
tumor necrosis factor-alpha	Lopes, 2012	patients and normal controls		PBMCs of MDD patients produced significantly lower interleuk...... PBMCs of MDD patients produced significantly lower interleukin (IL)-2, IL-4 and tumor necrosis factor-alpha levels when compared to healthy controls. More...
tumor necrosis factor alpha	Crnkovic D, 2012	patients and normal controls		Study results showed a statistically significant difference ...... Study results showed a statistically significant difference in the concentrations of inflammatory markers (C-reactive protein (CRP), interleukin-6 and tumor necrosis factor alpha) between the group of MDD subjects and control group of healthy subjects. These concentrations were higher in MDD subjects. More...

Positive relationships between Tumor necrosis factor and other components at different levels (count: 6)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
tumor necrosis factor (TNF)-alpha		Pro-opiomelanocortin(ACTH)	protein	Schuld, 2003	patients only		Baseline TNF-alpha levels were negatively correlated with th...... Baseline TNF-alpha levels were negatively correlated with the amount of ACTH released upon CRH stimulation during the DEX/CRH test. More...
TNF¦Á		B1 bradykinin receptor(Kinin B1 receptors)	protein	Viana AF, 2010	animal model		The increased immobility time following LPS treatment was pr...... The increased immobility time following LPS treatment was preceded by an enhancement of hippocampal and cortical B1 receptor mRNA expression (which were maximal at 1 h), and a marked production of TNFalpha in serum, brain and cerebrospinal fluid (between 1 and 6 h) More...
TNFalpha		Depression-like behaviors from animal model(depressive-like behavior)	cognition and behavior	Viana AF, 2010	animal model		The depression-like behavior was virtually abolished in TNFa...... The depression-like behavior was virtually abolished in TNFalpha p55 receptor-knockout mice More...
tumor necrosis factor-alpha (TNF-alpha)		Suicide(suicide)	symptoms	Gabbay, 2009	patients and normal controls	P-value = 0.03	suicidal adolescents with MDD had significantly decreased pl...... suicidal adolescents with MDD had significantly decreased plasma TNF-alpha concentrations compared to nonsuicidal adolescents with MDD (1.33 +/- 2.95 pg/mL versus 30.9 +/- 110.9 pg/mL; p = 0.03) More...
tumor necrosis factor-alpha (TNFalpha)		Low energy(decreased activity)	symptoms	Eller, 2009	patients and normal controls		TNFalpha was associated with decreased activity and suicidal...... TNFalpha was associated with decreased activity and suicidality. More...
tumor necrosis factor-alpha (TNFalpha)		Suicide(suicidality)	symptoms	Eller, 2009	patients and normal controls		TNFalpha was associated with decreased activity and suicidal...... TNFalpha was associated with decreased activity and suicidality. More...

Positive relationship network of Tumor necrosis factor in MK4MDD

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1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between Tumor necrosis factor and MDD (count: 3)

Name in Literature	Reference	Research Type	Relation Description
TNF alpha	Farid Hosseini R, 2007	patients and nomal controls	We found no significant differences in plasma concentration ...... We found no significant differences in plasma concentration of IL-4, IL-10, TNF-alpha, IFN-gamma, and immunoglobulins as well as total number of NK cells, B cells, and T cells between major depressed patients and healthy control subjects. More...
tumor necrosis factor-alpha	Einvik G, 2012	patients and normal controls	Group comparisons revealed no significant difference in the ...... Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1beta, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1beta] between persons with (n=34) and without MDD (n=68) More...
TNF-alpha	Hughes MM, 2012	patients and normal controls	Whilst no changes in TNF-alpha or IL-1beta were observed, pl...... Whilst no changes in TNF-alpha or IL-1beta were observed, plasma concentrations of IL-6, IFN-gamma and CRP were increased in the depressed cohort. More...

Negative relationships between Tumor necrosis factor and other components at different levels (count: 0)

Related Gene Info

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
TNF	tumor necrosis factor	Literature-origin; SNP mapped; Protein mapped	5 (5/0)