MK4MDD

Protein Report

Basic Information
Protein Name Tumor necrosis factor
UniPortKB P01375
No. of Studies (Positive/Negative) 14 (10/4) Help
Type Literature-origin
Positive relationship between Tumor necrosis factor and MDD (count: 7)
Name in Literature Reference Research Type Statistical Result Relation Description Help
TNF-alpha Pavon, 2006 patients and normal controls The MDD subjects showed higher levels of cortisol and TNF-al...... The MDD subjects showed higher levels of cortisol and TNF-alpha, More...
TNF-¦Á Leo, 2006 patients and normal controls Compared with control subjects, MDD patients had higher base...... Compared with control subjects, MDD patients had higher baseline levels of TNF-¦Á More...
tumor necrosis factor-alpha (TNF-alpha) Kim, 2007 patients and normal controls At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN...... At admission, IL-6, TNF-alpha, TGF-beta1 production, and IFN-gamma/IL-4 ratio were significantly higher in MDD patients. More...
TNF-¦Á Piletz, 2010 patients and normal controls P-value=0.04 Compared to controls, patients with MDD had significantly hi...... Compared to controls, patients with MDD had significantly higher baseline levels of tumour necrosis factor-alpha (TNFalpha, P=0.04) in the blood. More...
tumor necrosis factor-alpha (TNFalpha) Eller, 2009 patients and normal controls Tumor necrosis factor-alpha (TNFalpha) levels were higher in...... Tumor necrosis factor-alpha (TNFalpha) levels were higher in drug-nalve patients with major depressive disorder with recurrent episode compared with previously treated patients. More...
tumor necrosis factor-alpha Lopes, 2012 patients and normal controls PBMCs of MDD patients produced significantly lower interleuk...... PBMCs of MDD patients produced significantly lower interleukin (IL)-2, IL-4 and tumor necrosis factor-alpha levels when compared to healthy controls. More...
tumor necrosis factor alpha Crnkovic D, 2012 patients and normal controls Study results showed a statistically significant difference ...... Study results showed a statistically significant difference in the concentrations of inflammatory markers (C-reactive protein (CRP), interleukin-6 and tumor necrosis factor alpha) between the group of MDD subjects and control group of healthy subjects. These concentrations were higher in MDD subjects. More...

Positive relationships between Tumor necrosis factor and other components at different levels (count: 6) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Positive relationship network of Tumor necrosis factor in MK4MDD
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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Tumor necrosis factor and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description
TNF alpha Farid Hosseini R, 2007 patients and nomal controls We found no significant differences in plasma concentration ...... We found no significant differences in plasma concentration of IL-4, IL-10, TNF-alpha, IFN-gamma, and immunoglobulins as well as total number of NK cells, B cells, and T cells between major depressed patients and healthy control subjects. More...
tumor necrosis factor-alpha Einvik G, 2012 patients and normal controls Group comparisons revealed no significant difference in the ...... Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1beta, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1beta] between persons with (n=34) and without MDD (n=68) More...
TNF-alpha Hughes MM, 2012 patients and normal controls Whilst no changes in TNF-alpha or IL-1beta were observed, pl...... Whilst no changes in TNF-alpha or IL-1beta were observed, plasma concentrations of IL-6, IFN-gamma and CRP were increased in the depressed cohort. More...

Negative relationships between Tumor necrosis factor and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
TNF tumor necrosis factor Literature-origin; SNP mapped; Protein mapped 7 (7/0)