Protein Report

Basic Information

Protein Name	Sodium-dependent dopamine transporter
UniPortKB	Q01959
No. of Studies (Positive/Negative)	6 (6/0)
Type	Literature-origin

Positive relationship between Sodium-dependent dopamine transporter and MDD (count: 5)

Name in Literature	Reference	Research Type	Relation Description
dopamine transporter	Meyer, 2001	patients and normal controls	Low striatal dopamine transporter binding potential (DAT BP)...... Low striatal dopamine transporter binding potential (DAT BP) in major depressive episodes is consistent with a downregulation of DAT (dopamine transporter) . More...
dopamine transporter	Klimek, 2002	patients and normal controls	The binding of [(125)I]RTI 55 to DA (dopamine) transporter w...... The binding of [(125)I]RTI 55 to DA (dopamine) transporter was significantly lower in the basal and central amygdaloid nuclei in major depression compared with control subjects. More...
dopamine transporter	Brunswick, 2003	patients and normal controls	The specific uptake values of [(99m)Tc]TRODAT-1 (a selective...... The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects. More...
dopamine transporter (DAT)	Yang, 2008	patients and normal controls	DAT binding in the patient group were significantly higher t...... DAT binding in the patient group were significantly higher than in control group. More...
dopamine transporter	Lehto, 2008	patients and normal controls	Major depression groups had lower midbrain [123I] nor-beta-C...... Major depression groups had lower midbrain [123I] nor-beta-CIT(a selective dopamine transporter imaging agent) binding compared with the controls. More...

Positive relationships between Sodium-dependent dopamine transporter and other components at different levels (count: 8)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
dopamine transporter		Dopamine(dopamine)	molecule	Meyer, 2001	patients and normal controls		Lower dopamine transporter binding potential (DAT BP) itself...... Lower dopamine transporter binding potential (DAT BP) itself reduces extracellular clearance of dopamine. More...
dopamine transporter		Basal amygdaloid nuclei(basal amygdaloid nuclei)	brain morphology and function	Klimek, 2002	patients and normal controls		The binding of [(125)I]RTI 55 to DA (dopamine) transporter w...... The binding of [(125)I]RTI 55 to DA (dopamine) transporter was significantly lower in the basal and central amygdaloid nuclei in major depression compared with control subjects. More...
dopamine transporter		Central amygdaloid nuclei(central amygdaloid nuclei)	brain morphology and function	Klimek, 2002	patients and normal controls		The binding of [(125)I]RTI 55 to DA (dopamine) transporter w...... The binding of [(125)I]RTI 55 to DA (dopamine) transporter was significantly lower in the basal and central amygdaloid nuclei in major depression compared with control subjects. More...
dopamine transporter		left putamen(left posterior putamen)	brain morphology and function	Brunswick, 2003	patients and normal controls		The specific uptake values of [(99m)Tc]TRODAT-1 (a selective...... The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects. More...
dopamine transporter		right putamen(right anterior putamen)	brain morphology and function	Brunswick, 2003	patients and normal controls		The specific uptake values of [(99m)Tc]TRODAT-1 (a selective...... The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects. More...
dopamine transporter		right putamen(right posterior putamen)	brain morphology and function	Brunswick, 2003	patients and normal controls		The specific uptake values of [(99m)Tc]TRODAT-1 (a selective...... The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects. More...
dopamine transporter		Midbrain(midbrain)	brain morphology and function	Lehto, 2008	patients and normal controls		Major depression groups had lower midbrain [123I] nor-beta-C...... Major depression groups had lower midbrain [123I] nor-beta-CIT(a selective dopamine transporter imaging agent) binding compared with the controls. More...
dopamine transporter (DAT)		Depressed mood(depression)	symptoms	Newberg, 2007	normal people	P-value=0.009	We observed a greater Tc-TRODAT-1(selective DAT radiopharmac...... We observed a greater Tc-TRODAT-1(selective DAT radiopharmaceutical) DVR (distribution volume ratios) in the right caudate of subjects with high POMS (Profile of Mood States) mood scores compared to subjects with low scores on depressive items on the POMS (2.99+/-0.35 and 2.79+/-0.35, respectively; P=0.009). More...

Positive relationship network of Sodium-dependent dopamine transporter in MK4MDD

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1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between Sodium-dependent dopamine transporter and MDD (count: 0)

Negative relationships between Sodium-dependent dopamine transporter and other components at different levels (count: 0)

Related Gene Info

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Literature-origin; SNP mapped; Protein mapped	3 (2/1)