MK4MDD

Protein Report

Basic Information
Protein Name Sodium-dependent dopamine transporter
UniPortKB Q01959
No. of Studies (Positive/Negative) 6 (6/0) Help
Type Literature-origin
Positive relationship between Sodium-dependent dopamine transporter and MDD (count: 5)
Name in Literature Reference Research Type Statistical Result Relation Description Help
dopamine transporter Meyer, 2001 patients and normal controls Low striatal dopamine transporter binding potential (DAT BP)...... Low striatal dopamine transporter binding potential (DAT BP) in major depressive episodes is consistent with a downregulation of DAT (dopamine transporter) . More...
dopamine transporter Klimek, 2002 patients and normal controls The binding of [(125)I]RTI 55 to DA (dopamine) transporter w...... The binding of [(125)I]RTI 55 to DA (dopamine) transporter was significantly lower in the basal and central amygdaloid nuclei in major depression compared with control subjects. More...
dopamine transporter Brunswick, 2003 patients and normal controls The specific uptake values of [(99m)Tc]TRODAT-1 (a selective...... The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects. More...
dopamine transporter (DAT) Yang, 2008 patients and normal controls DAT binding in the patient group were significantly higher t...... DAT binding in the patient group were significantly higher than in control group. More...
dopamine transporter Lehto, 2008 patients and normal controls Major depression groups had lower midbrain [123I] nor-beta-C...... Major depression groups had lower midbrain [123I] nor-beta-CIT(a selective dopamine transporter imaging agent) binding compared with the controls. More...

Positive relationships between Sodium-dependent dopamine transporter and other components at different levels (count: 8) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Positive relationship network of Sodium-dependent dopamine transporter in MK4MDD
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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Sodium-dependent dopamine transporter and MDD (count: 0)
Negative relationships between Sodium-dependent dopamine transporter and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 Literature-origin; Protein mapped 3 (2/1)