Brain Morphology and Function Report

Basic Information

Name	Parietal Lobe
Brain Morphology	The parietal lobe is a part of the Brain positioned above (superior to) the occipital lobe and behind (posterior to) the frontal lobe. The parietal lobe is defined by four anatomical boundaries: the central sulcus separates the parietal lobe from the frontal lobe; the parieto-occipital sulcus separates the parietal and occipital lobes; the lateral sulcus (sylvian fissure) is the most lateral boundary separating it from the temporal lobe; and the medial longitudinal fissure divides the two hemispheres. The parietal lobe integrates sensory information from different modalities, particularly determining spatial sense and navigation.
Brain Function	Parietal Lobe- associated with movement, orientation, recognition, perception of stimuli
Picture	Source
No. of Studies (Positive/Negative)	11(11/0)

Positive relationships between Parietal Lobe and MDD (count: 8)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
parietal neocortex	Ballard, 2002	patients only	BA 7a area 1 t = 3.3, P-value = 0.004; BA 7a area 3 t = 3.8, P-value = 0.001	Major depression was associated with a significant preservat...... Major depression was associated with a significant preservation of 5HT transporter re-uptake sites in the parietal neocortex compared with non-affected cases (BA 7a area 1 t = 3.3, P = 0.004; BA 7a area 3 t = 3.8, P = 0.001). More...
parietal cortical regions	Anderson, 2004	patients and normal controls		Unlike healthy male subjects who have significant increases ...... Unlike healthy male subjects who have significant increases in rCMRglu in prefrontal and parietal cortical regions after receiving fenfluramine, depressed male subjects have no significant increases in rCMRglu. More...
parietal region	Fujimoto, 2008	patients only		The 3D-SSP score map showed decreased relative metabolism in...... The 3D-SSP score map showed decreased relative metabolism in the parietal region in both hemispheres in patients compared with controls. More...
parietal lobes	Halari, 2009	patients and normal controls		Adolescents with depression compared to healthy controls dem...... Adolescents with depression compared to healthy controls demonstrated reduced activation in the parietal lobes during the Stop and Switch tasks More...
parietal regions	Werner, 2009	patients and normal controls		during encoding, depressive patients showed increased activi...... during encoding, depressive patients showed increased activity in the left parahippocampal gyrus and decreased activity in frontal and parietal regions. More...
parietal lobe	Abe, 2010	patients and normal controls		Local areas showing significant gray matter volume reduction...... Local areas showing significant gray matter volume reduction in depressive patients compared with controls were observed in the left parietal lobe More...
posterior areas	Silveira, 2010	patients only		Our cross-sectional study showed that a lower mean frequency...... Our cross-sectional study showed that a lower mean frequency (MF) in posterior areas is related to depression in the elderly. More...
parietal regions	Zhang, 2011	patients and normal controls		The MDD patients exhibited increased nodal centralities, pre...... The MDD patients exhibited increased nodal centralities, predominately in the default-mode regions, including the parietal regions. More...

Positive relationships between Parietal Lobe and other components at different levels (count: 3)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
parietal cortical areas		Low energy(loss of motivated behavior)	symptoms	Milak, 2005	patients only	Loss of motivated behavior was negatively associated with pa...... Loss of motivated behavior was negatively associated with parietal and superior frontal cortical areas. More...
parietal regions		Suicide(suicide)	symptoms	Hwang, 2010	patients and normal controls	Compared with nonsuicidal counterpart, suicidal depression w...... Compared with nonsuicidal counterpart, suicidal depression was associated with decreased GM(gray matter) and WM(white matter) volume in the parietal regions More...
parietal regions		Psychotic symptoms(delusion)	symptoms	Lee, 2011	patients only	A higher symptom severity of delusion was associated with hi...... A higher symptom severity of delusion was associated with higher regional power in the frontal and temporal regions, and lower strengths at inter-hemispheric (frontal, temporal and parietal) and fronto-temporo-parietal connections. More...

Positive relationship network of Parietal Lobe in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between Parietal Lobe and MDD (count: 0)

Negative relationships between Parietal Lobe and other components at different levels (count: 0)