MK4MDD

Pathway Report

Basic Information
Name Long-term depression
KEGG Link ID: hsa04730
Name: long term_depression
Brief Description: Long-term depression
Full Description: Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization.
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between Long-term depression and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
Long-term depression Kao CF, 2012 patients and normal controls We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

Positive relationships between Long-term depression and other components at different levels (count: 0) Help
Positive relationship network of Long-term depression in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
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3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Long-term depression and MDD (count: 0)
Negative relationships between Long-term depression and other components at different levels (count: 0) Help
Pathway Long-term depression related genes in MK4MDD (count: 20)