Brain Morphology and Function Report

Basic Information

Name	Fronto-parietal connection
Brain Morphology	The fronto-parietal connection contains frontal cortex and parietal cortex and their connectivity.
No. of Studies (Positive/Negative)	19(19/0)

Positive relationships between Fronto-parietal connection and MDD (count: 10)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
frontal cortex	Grimm, 2008	patients and normal controls		The MDD patients showed hypoactivity in the left DLPFC durin...... The MDD patients showed hypoactivity in the left DLPFC during both unattended and attended emotional judgment. More...
parietal cortex	Awata, 1998	patients and normal controls		(patients with major depressive disorder in late life) compa...... (patients with major depressive disorder in late life) compared with 13 age-matched controls, relative rCBF(regional cerebral blood flow) was significantly decreased bilaterally in the parietal cortex More...
frontal cortex	Pagani, 2004	patients and normal controls	P<0.025	As compared to normal controls, MDD rCBF (regional cerebral ...... As compared to normal controls, MDD rCBF (regional cerebral blood flow) was relatively higher in frontal cortex ( P<0.025), More...
frontal cortex	Graff-Guerrero, 2004	patients only		The frontal cortex plays an important role in the expression...... The frontal cortex plays an important role in the expression of MDD symptoms. More...
frontal cortex	Nofzinger, 2005	patients and normal controls		Depressed patients showed smaller decreases than healthy sub...... Depressed patients showed smaller decreases than healthy subjects in relative metabolism in broad regions of the frontal cortex from waking to NREM sleep. More...
parietal cortex	Nofzinger, 2005	patients and normal controls		Depressed patients showed smaller decreases than healthy sub...... Depressed patients showed smaller decreases than healthy subjects in relative metabolism in broad regions of the parietal cortex from waking to NREM sleep. More...
frontal cortex	Kohn, 2007	patients and normal controls		Baseline rCBF (regional cerebral blood flow) was lower in de...... Baseline rCBF (regional cerebral blood flow) was lower in depressed patients than in controls in the frontal cortex and subcortical nuclei bilaterally. More...
frontal cortex	Michopoulos, 2008	patients and normal controls		MDD patients showed neuropsychological deficits on tasks of ...... MDD patients showed neuropsychological deficits on tasks of executive function and memory, supporting the model of frontal-temporal dysfunction More...
frontal cortex	Selvaraj, 2011	patients and normal controls		The depressed patients had lowered 5-HTT binding in several ...... The depressed patients had lowered 5-HTT binding in several brain regions including frontal cortex. More...
frontal cortex	Jiao, 2011	patients and normal controls		Resting brain activity levels measured by ALFF was higher in...... Resting brain activity levels measured by ALFF was higher in the frontal cortex than that in the subcortical system involving mainly (para) limbic-striatal regions in both HC and MDD adolescents. More...

Positive relationships between Fronto-parietal connection and other components at different levels (count: 11)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Related Components
Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
frontal cortex		5-hydroxytryptamine receptor 2A(5-HT2 receptor (serotonin-2 receptor))	protein	Yatham, 1999	patients only		The decrease in 5-HT2 receptor binding was observed bilatera...... The decrease in 5-HT2 receptor binding was observed bilaterally and was particularly prominent in frontal cortex. More...
frontal cortex		ATP-citrate synthase(citrate synthase)	protein	Gardner, 2008	patients only		Voxel-based analysis showed significantly higher 99mTc-HMPAO...... Voxel-based analysis showed significantly higher 99mTc-HMPAO retention in the patients with low CS (citrate synthase) compared with the patients with normal CS in the posterior and inferior frontal cortex, the superior and posterior temporal cortex, the somato-sensory cortex, and the associative parietal cortex. More...
parietal cortex		ATP-citrate synthase(citrate synthase)	protein	Gardner, 2008	patients only		Voxel-based analysis showed significantly higher 99mTc-HMPAO...... Voxel-based analysis showed significantly higher 99mTc-HMPAO retention in the patients with low CS (citrate synthase) compared with the patients with normal CS in the posterior and inferior frontal cortex, the superior and posterior temporal cortex, the somato-sensory cortex, and the associative parietal cortex. More...
parietal cortex		Erythropoietin(erythropoietin (Epo))	protein	Miskowiak, 2009	patients only		Erythropoietin (Epo) reduced neural response to negative vs....... Erythropoietin (Epo) reduced neural response to negative vs. positive pictures 3 days post-administration in a network of areas including the hippocampus, ventromedial prefrontal and parietal cortex. More...
frontal cortex		anhedonic-like behavior from animal model(anhedonic-like behavior)	cognition and behavior	Tordera RM, 2011	animal model		gene expression changes in the frontal cortex gene expression changes in the frontal cortex
frontal cortex		anhedonic-like behavior from animal model(anhedonic-like behavior)	cognition and behavior	Qi X, 2009	animal model		The ERK pathway inhibition in the medial prefrontal cortex i...... The ERK pathway inhibition in the medial prefrontal cortex induced anhedonia and locomotor impairment in rats More...
frontal cortex		Low energy(psychomotor retardation)	symptoms	Dunn, 2002	patients only		In unipolars, the negative cognitions cluster correlated wit...... In unipolars, the negative cognitions cluster correlated with lower absolute metabolism bilaterally in right dorsolateral frontal cortex. More...
frontal cortex		Irritability(impulsivity)	symptoms	Oquendo, 2005	patients only		Impulsivity was positively correlated with rCMRglu in superi...... Impulsivity was positively correlated with rCMRglu in superior and middle frontal cortex (BA 6 and 44). More...
frontal cortex		Suicide(suicide attempt)	symptoms	Lalovic, 2010	patients and normal controls		Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp...... Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects More...
fronto-parietal connection		Increased agitation(somatic anxiety)	symptoms	Lee, 2011	patients only		A higher symptom severity of somatic anxiety was associated ...... A higher symptom severity of somatic anxiety was associated with higher regional power over widespread cortical regions and lower strengths at bi-temporal, temporo-parietal and fronto-parietal connections. More...
frontal cortex		Stress(stress)	environment	Li HC, 2007	animal model		Nitric oxide contents in prefrontal cortex and hippocampus w...... Nitric oxide contents in prefrontal cortex and hippocampus were significantly higher More...

Positive relationship network of Fronto-parietal connection in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between Fronto-parietal connection and MDD (count: 0)

Negative relationships between Fronto-parietal connection and other components at different levels (count: 0)

Fronto-parietal connection involved components (count: 2)

Name	Type
Frontal Lobe	brain morphology and function
Parietal Lobe	brain morphology and function