Protein Report

Basic Information

Protein Name	D(3) dopamine receptor
UniPortKB	P35462
No. of Studies (Positive/Negative)	6 (6/0)
Type	Literature-origin

Positive relationship between D(3) dopamine receptor and MDD (count: 4)

Name in Literature	Reference	Research Type	Relation Description
dopamine D3 receptor	Shah, 1997	patients and normal controls	Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratio...... Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratios were significantly higher in depressed patients than controls. More...
dopamine D3 receptor	Klimek, 2002	patients and normal controls	The binding of [(125)I]epidepride to D3 receptors was signif...... The binding of [(125)I]epidepride to D3 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects. More...
D3 receptor	Montgomery, 2007	patients and normal controls	[(11)C]raclopride binding was reduced in the dorsal striatum...... [(11)C]raclopride binding was reduced in the dorsal striatum of people taking antidepressants suggesting that D(2/3) expression was reduced compared to untreated controls. More...
D3 receptor	Lehto, 2008	patients and normal controls	Among the major depressives there was a strong bilateral cor...... Among the major depressives there was a strong bilateral correlation between the scores on the 21-item Hamilton Depression Rating Scale and D(2/3) receptor binding. More...

Positive relationships between D(3) dopamine receptor and other components at different levels (count: 7)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
dopamine D3 receptor		right striatum(right striatal region)	brain morphology and function	Shah, 1997	patients and normal controls	Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratio...... Right striatal 123I-IBZM (dopamine D2/3 ligand) uptake ratios were significantly higher in depressed patients than controls. More...
dopamine D3 receptor		Amygdala(amygdaloid nuclei)	brain morphology and function	Klimek, 2002	patients and normal controls	The binding of [(125)I]epidepride to D3 receptors was signif...... The binding of [(125)I]epidepride to D3 receptors was significantly higher in the basal, central, and lateral amygdaloid nuclei in major depression compared with control subjects. More...
D3 receptor		Striatum(striatum)	brain morphology and function	Montgomery, 2007	patients and normal controls	[(11)C]raclopride binding was reduced in the dorsal striatum...... [(11)C]raclopride binding was reduced in the dorsal striatum of people taking antidepressants suggesting that D(2/3) expression was reduced compared to untreated controls. More...
dopamine D3 receptor		Reaction time(reaction time)	cognition and behavior	Shah, 1997	patients and normal controls	There were significant correlations between 123I-IBZM (dopam...... There were significant correlations between 123I-IBZM (dopamine D2/3 ligand) binding in left and right striatum and measures of reaction time. More...
dopamine D3 receptor		Language(verbal fluency)	cognition and behavior	Shah, 1997	patients and normal controls	There were significant correlations between 123I-IBZM (dopam...... There were significant correlations between 123I-IBZM (dopamine D2/3 ligand) binding in left and right striatum and measures of verbal fluency. More...
dopamine D3 receptor		Low energy(psychomotor retardation)	symptoms	Ebert, 1996	patients and normal controls	123I-IBZM (dopamine D2/3 ligand) binding was increased in de...... 123I-IBZM (dopamine D2/3 ligand) binding was increased in depressed patients with psychomotor retardation. More...
dopamine D3 receptor		Depressed mood(depressed mood)	symptoms	Willner, 2005	patients and normal controls	In the antidepressant-treated patients, a low dose of the se...... In the antidepressant-treated patients, a low dose of the selective dopamine D2/D3 receptor antagonist sulpiride caused a substantial reinstatement of depressed mood. More...

Positive relationship network of D(3) dopamine receptor in MK4MDD

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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between D(3) dopamine receptor and MDD (count: 0)

Negative relationships between D(3) dopamine receptor and other components at different levels (count: 0)

Related Gene Info

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
DRD3	dopamine receptor D3	SNP mapped; Protein mapped	0 (0/0)