Protein Report

Protein Name	Cyclic AMP-responsive element-binding protein 1
UniPortKB	P16220
No. of Studies (Positive/Negative)	7 (7/0)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CREB	Yamada, 2003	patients and normal controls		Immunoreactivies of both CREB and phosphorylated CREB were s...... Immunoreactivies of both CREB and phosphorylated CREB were significantly decreased in depressive subjects compared to controls. More...
CREB	Laifenfeld, 2005	patients and normal controls		Levels of CAM-L1 and of phosphorylated CREB (pCREB) were inc...... Levels of CAM-L1 and of phosphorylated CREB (pCREB) were increased in the prefrontal cortex of the depressed group, while CAM-L1, laminin and pCREB were decreased in the parieto-occipital cortex. More...
CREB	Ren, 2011	patients and normal controls		We found that the CRE-DNA binding activity and CREB protein ...... We found that the CRE-DNA binding activity and CREB protein expression were significantly decreased in the neutrophils of drug-free MDD patients compared with normal control subjects. More...
Cyclic-AMP response element binding (CREB) protein	Ren, 2011	patients and normal controls		The CRE-DNA binding activity and CREB protein expression wer...... The CRE-DNA binding activity and CREB protein expression were significantly decreased in the neutrophils of drug-free MDD patients compared with normal control subjects. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
cAMP response element-binding protein (CREB)		BDNF(BDNF)	gene	Schmidt HD, 2010	animal model		BDNF levels as well as expression of pCREB and pERK were ele...... BDNF levels as well as expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF More...
CREB		Brain-derived neurotrophic factor(BDNF)	protein	Schmidt HD, 2010	animal model		Expression of pCREB and pERK were elevated in the hippocampu...... Expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF More...
cAMP response element-binding protein (CREB)		mapkkk cascade(ERK pathway)	pathway	Qi X, 2009	animal model		The phosphorylation of the cyclic AMP-responsive-element-bin...... The phosphorylation of the cyclic AMP-responsive-element-binding protein (CREB) was decreased following the ERK pathway inhibition More...
cAMP response element-binding protein (CREB)		Emotion(conditioned fear)	cognition and behavior	Muschamp JW, 2011	animal model		Elevation of CREB within the nucleus accumbens shell impaire...... Elevation of CREB within the nucleus accumbens shell impaired extinction of conditioned fear More...
cAMP response element-binding protein (CREB)		anhedonic-like behavior from animal model(anhedonic-like behavior)	cognition and behavior	Muschamp JW, 2011	animal model		Elevated CREB within the nucleus accumbens shell produced in...... Elevated CREB within the nucleus accumbens shell produced increases in intracranial self-stimulation thresholds, a depressive-like sign reflecting anhedonia More...
CREB		Suicide(suicide attempt)	symptoms	Dowlatshahi, 1999	patients and normal controls		We also detected a significant effect of suicide on temporal...... We also detected a significant effect of suicide on temporal cortex CREB levels in subjects that died as a result of suicide relative to those that did not, which was more evident in patients with major depressive disorder. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
CREB1	cAMP responsive element binding protein 1	Literature-origin; Protein mapped	12 (10/2)