Protein Report

Basic Information

Protein Name	Amine oxidase [flavin-containing] A
UniPortKB	P21397
No. of Studies (Positive/Negative)	4 (4/0)
Type	Literature-origin

Positive relationship between Amine oxidase [flavin-containing] A and MDD (count: 4)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
monoamine oxidase A (MAO-A)	Meyer, 2006	patients and normal controls	P-value<=0.001	The MAO-A DVS (specific distribution volume) was highly sign...... The MAO-A DVS (specific distribution volume) was highly significantly elevated in every brain region assessed (t test; P=.001 to 3x10(-7)). The MAO-A DVS was elevated on average by 34% (2 SDs) throughout the brain during major depression. More...
monoamine oxidase A (MAO-A)	Meyer, 2009	patients and normal controls		Monoamine oxidase A V(T), an index of MAO-A density, was sig...... Monoamine oxidase A V(T), an index of MAO-A density, was significantly elevated in each brain region both during MDE (major depressive episodes) and after SSRI treatment as compared with healthy controls. More...
monoamine oxidase A	Zhang, 2010	patients and normal controls		quantity of MAOA messenger RNA was significantly higher in p...... quantity of MAOA messenger RNA was significantly higher in patients with MDD than in control subjects (fold change = 5.28, p = 1.7 ¡Á 10^-7) More...
MAO A	Johnson, 2011	patients and normal controls	P-value<0.05	An increase (approximately 40%; p<0.05) in MAO A protein lev...... An increase (approximately 40%; p<0.05) in MAO A protein levels within the MDD groups compared with controls, the MAO A catalytic activity was significantly greater in both MDD groups compared with controls More...

Positive relationships between Amine oxidase [flavin-containing] A and other components at different levels (count: 12)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Related Components
Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
monoamine oxidase A		Ribonucleoside-diphosphate reductase large subunit(R1)	protein	Johnson, 2011	patients and normal controls	P-value<0.05	Western blot analysis showed that R1 was significantly decre...... Western blot analysis showed that R1 was significantly decreased by 37.5% (p<0.005) in untreated MDD subjects. The R1 level in medicated MDD subjects was also significantly lower (by 30%; p<0.05) compared with control subjects, but was not significantly different compared with untreated MDD subjects. Interestingly, the reduction in R1 was significantly correlated with an increase (approximately 40%; p<0.05) in MAO A protein levels within the MDD groups compared with controls. More...
monoamine oxidase A (MAO-A)		Monoamine neurotransmitters(monoamine neurotransmitters)	neurobiological system	Meyer, 2006	patients and normal controls		The sizable magnitude of this finding and the absence of oth...... The sizable magnitude of this finding and the absence of other compelling explanations for monoamine loss during major depressive episodes led to the conclusion that elevated MAO-A density is the primary monoamine-lowering process during major depression. More...
monoamine oxidase A (MAO-A)		Anterior cingulate cortex(anterior cingulate cortex)	brain morphology and function	Meyer, 2006	patients and normal controls		The MAO-A DVS (specific distribution volume) was highly sign...... The MAO-A DVS (specific distribution volume) was highly significantly elevated in anterior cingulate cortex. More...
monoamine oxidase A (MAO-A)		anterior temporal cortex(anterior temporal cortex)	brain morphology and function	Meyer, 2006	patients and normal controls		The MAO-A DVS (specific distribution volume) was highly sign...... The MAO-A DVS (specific distribution volume) was highly significantly elevated in anterior temporal cortex. More...
monoamine oxidase A (MAO-A)		Caudate nucleus(caudate)	brain morphology and function	Meyer, 2006	patients and normal controls		The MAO-A DVS (specific distribution volume) was highly sign...... The MAO-A DVS (specific distribution volume) was highly significantly elevated in caudate. More...
monoamine oxidase A (MAO-A)		Hippocampus(hippocampus)	brain morphology and function	Meyer, 2006	patients and normal controls		The MAO-A DVS (specific distribution volume) was highly sign...... The MAO-A DVS (specific distribution volume) was highly significantly elevated in hippocampus. More...
monoamine oxidase A (MAO-A)		Midbrain(midbrain)	brain morphology and function	Meyer, 2006	patients and normal controls		The MAO-A DVS (specific distribution volume) was highly sign...... The MAO-A DVS (specific distribution volume) was highly significantly elevated in midbrain. More...
monoamine oxidase A (MAO-A)		Parahippocampal gyrus(parahippocampus)	brain morphology and function	Meyer, 2006	patients and normal controls		The MAO-A DVS (specific distribution volume) was highly sign...... The MAO-A DVS (specific distribution volume) was highly significantly elevated in parahippocampus. More...
monoamine oxidase A (MAO-A)		Posterior cingulate cortex(posterior cingulate cortex)	brain morphology and function	Meyer, 2006	patients and normal controls		The MAO-A DVS (specific distribution volume) was highly sign...... The MAO-A DVS (specific distribution volume) was highly significantly elevated in posterior cingulate cortex. More...
monoamine oxidase A (MAO-A)		Prefrontal cortex(prefrontal cortex)	brain morphology and function	Meyer, 2006	patients and normal controls		The MAO-A DVS (specific distribution volume) was highly sign...... The MAO-A DVS (specific distribution volume) was highly significantly elevated in prefrontal cortex. More...
monoamine oxidase A (MAO-A)		Putamen(putamen)	brain morphology and function	Meyer, 2006	patients and normal controls		The MAO-A DVS (specific distribution volume) was highly sign...... The MAO-A DVS (specific distribution volume) was highly significantly elevated in putamen. More...
monoamine oxidase A (MAO-A)		Thalamus(thalamus)	brain morphology and function	Meyer, 2006	patients and normal controls		The MAO-A DVS (specific distribution volume) was highly sign...... The MAO-A DVS (specific distribution volume) was highly significantly elevated in thalamus. More...

Positive relationship network of Amine oxidase [flavin-containing] A in MK4MDD

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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between Amine oxidase [flavin-containing] A and MDD (count: 0)

Negative relationships between Amine oxidase [flavin-containing] A and other components at different levels (count: 0)

Related Gene Info

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
MAOA	monoamine oxidase A	Literature-origin; SNP mapped; Protein mapped	12 (9/3)