Protein Report

Basic Information

Protein Name	Protein S100-B
UniPortKB	P04271
No. of Studies (Positive/Negative)	4 (4/0)
Type	Literature-origin

Positive relationship between Protein S100-B and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
S100B	Schroeter, 2008	patients and normal controls		S100B was elevated at admission and discharge in our patient...... S100B was elevated at admission and discharge in our patients with major depression compared with control subjects More...
S100B	Yang, 2008	patients and normal controls		The S100B levels in major depressed patients were significan...... The S100B levels in major depressed patients were significantly higher than those in controls. More...

Positive relationships between Protein S100-B and other components at different levels (count: 5)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
s100 calcium binding protein b		Brain-derived neurotrophic factor(BDNF)	protein	Ye Y, 2011	animal model	CUMS produced decreased glial fibrillary acidic protein (GFA...... CUMS produced decreased glial fibrillary acidic protein (GFAP) expression and increased s100 calcium binding protein b (s100b) expression in rat hippocampus, which were partially rescued by BDNF administration More...
S100B		N200(N2)	neurobiological system	Dietrich, 2004	patients only	Patients with increased S100B serum levels (n=6) showed a no...... Patients with increased S100B serum levels (n=6) showed a normal N2- and P3-amplitude in contrast to a reduced N2- and P3-amplitude in patients with normal S100B serum levels (n=6). More...
S100B		P300(P3)	neurobiological system	Dietrich, 2004	patients only	Patients with increased S100B serum levels (n=6) showed a no...... Patients with increased S100B serum levels (n=6) showed a normal N2- and P3-amplitude in contrast to a reduced N2- and P3-amplitude in patients with normal S100B serum levels (n=6). More...
S100B		Attention(attentional processes)	cognition and behavior	Dietrich, 2004	patients only	Patients with increased S100B serum levels (n=6) showed a no...... Patients with increased S100B serum levels (n=6) showed a normal N2- and P3-amplitude in contrast to a reduced N2- and P3-amplitude in patients with normal S100B serum levels (n=6). These findings provide evidence of a correlation between S100B levels and attentional processes in patients with recurrent depression. More...
s100 calcium binding protein b		Stress(stress)	environment	Ye Y, 2011	animal model	CUMS produced decreased glial fibrillary acidic protein (GFA...... CUMS produced decreased glial fibrillary acidic protein (GFAP) expression and increased s100 calcium binding protein b (s100b) expression in rat hippocampus More...

Positive relationship network of Protein S100-B in MK4MDD

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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between Protein S100-B and MDD (count: 0)

Negative relationships between Protein S100-B and other components at different levels (count: 0)

Related Gene Info

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
S100B	S100 calcium binding protein B	Literature-origin; Protein mapped	3 (1/2)