MK4MDD

Environment Report

Basic Information
Name Child abuse
Description "Child abuse is the physical, sexual, emotional mistreatment, or neglect of children. Child abuse can occur in a child's home, or in the organizations, schools or communities the child interacts with. There are four major categories of child abuse: neglect, physical abuse, psychological/emotional abuse, and child sexual abuse. Child abuse (physical, emotional, sexual, or neglect) is also associated with increased risk of developing depressive disorders later in life. Such a link has good face validity given that it is during the years of development that a child is learning how to become a social being. Abuse of the child by the caregiver is bound to distort the developing personality and create a much greater risk for depression and many other debilitating mental and emotional states."
No. of Studies (Positive/Negative) 20(22/0) Help

Positive relationships between Child abuse and MDD (count: 8)
Name in Literature Reference Research Type Statistical Result Relation Description Help
childhood abuse Vythilingam, 2002 patients and normal controls The depressed subjects with childhood abuse had an 18% small...... The depressed subjects with childhood abuse had an 18% smaller mean left hippocampal volume than the nonabused depressed subjects and a 15% smaller mean left hippocampal volume than the healthy subjects. More...
childhood trauma Heim, 2008 patients and normal controls Men with childhood trauma histories exhibited increases in A...... Men with childhood trauma histories exhibited increases in ACTH and cortisol responses to dexamethasone/CRF compared with non-abused men. In particular, abused men with current MDD showed increased responsiveness compared with control subjects and depressed men without childhood abuse experience More...
childhood adversity Lenze, 2008 patients and normal controls We found that childhood adversity was associated with a hist...... We found that childhood adversity was associated with a history of recurrent depression and with earlier age of depression onset. More...
emotional neglect Frodl, 2010 patients and normal controls Patients carrying the risk S-allele developed smaller hippoc...... Patients carrying the risk S-allele developed smaller hippocampal volumes when they had a history of emotional neglect compared with patients who only had one risk factor (environmental or genetic). More...
childhood sexual abuse Cong E, 2011 patients and normal controls Any form of CSA was significantly associated with recurrent ...... Any form of CSA was significantly associated with recurrent MD [OR 3.26, 95% confidence interval (CI) 1.95-5.45]. This association strengthened with increasing CSA severity: non-genital (OR 2.47, 95% CI 1.17-5.23), genital (OR 2.77, 95% CI 1.32-5.83) and intercourse (OR 13.35, 95% CI 1.83-97.42). The association between any form of CSA and MD remained significant after accounting for parental history of depression, childhood emotional neglect (CEN), childhood physical abuse (CPA) and parent-child relationship. Among the depressed women, those with CSA had an earlier age of onset, longer depressive episodes and an increased risk for generalized anxiety disorder (GAD; OR 1.92, 95% CI 1.39-2.66) and dysthymia (OR 2.16, 95% CI 1.52-3.09). More...
Physical abuse Gutierrez, 2015 patients only p<0.001 MD was found to be significantly associated with all types o...... MD was found to be significantly associated with all types of early maltreatment experiences (Table 2) More...
Sexual abuse Gutierrez, 2015 patients only p<0.001 MD was found to be significantly associated with all types o...... MD was found to be significantly associated with all types of early maltreatment experiences (Table 2) More...
Childhood Abuse Cruz-Fuentes, 2014 Patients and nomal controls The psychosocial adversity composite factors: Abuse, neglect...... The psychosocial adversity composite factors: Abuse, neglect, and family dysfunctions (Wald¡¯s 88.2, OR 3.6; CI 2.7¨C4.6; P < 0.001); parental maladjustment (Wald¡¯s 8.2, OR 1.9; CI 1.2¨C2.9; P < 0.01), parental death (Wald¡¯s 6.5, OR 2.0; CI 1.2¨C3.4; P < 0.01), and to have experienced a life-threatening physical illness (Wald¡¯s 7.0, OR 1.9; CI 1.2¨C3.1; P < 0.01) More...

Positive relationships between Child abuse and other components at different levels (count: 25) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Child abuse in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Child abuse and MDD (count: 0)
Negative relationships between Child abuse and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment