SNP Report

Basic Information

Name	rs1360780 dbSNP Ensembl
Location	Chrchr6:35639794(Forward)
Variant Alleles	T/C
Ancestral Allele	T
No. of Studies (Positive/Negative)	3 (2/1)

Positive relationship between rs1360780 and MDD (count: 1)

Reference	Research Type	Statistical Result	Relation Description
Szczepankiewicz, 2014	Patients and nomal controls	P-value=0.011	We observed an association of five FKBP5 polymorphisms (rs13...... We observed an association of five FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) with major depressive disorderas compared tothe control group (p=0.011; p=0.007, p=0.038; p=0.030; p=0.018, respectively). More...

Relationships between rs1360780 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
rs1360780		Child abuse(childhood abuse)	environment	Appel, 2011	normal people	RERI=6.8; 95% CI=0.64-33.7; P-value<0.05	Significant interaction (p=0.006) of physical abuse with the...... Significant interaction (p=0.006) of physical abuse with the TT genotype of rs1360780 was found increasing the BDI-II score to 17.4 (95% confidence interval (CI)=12.0-22.9) compared with 10.0 (8.2-11.7) in exposed CC/CT carriers. Likewise, the adjusted odds ratio for MDD in exposed TT carriers was 8.2 (95% CI=1.9-35.0) compared with 1.3 (0.8-2.3) in exposed subjects with CC/CT genotypes. Relative excess risk due to interaction (RERI) analyses confirmed a significant additive interaction effect (RERI=6.8; 95% CI=0.64-33.7; p<0.05). In explorative analyses, the most severe degree of sexual and emotional abuse also yielded significant interaction effects (p<0.05). More...

Positive relationship network of rs1360780 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between rs1360780 and MDD (count: 0)

Negative relationships between rs1360780 and other components at different levels (count: 1)

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
rs1360780		Stress(stressful life events)	environment	Shimasaki, 2014	Patients and nomal controls	P(ADD)=0.0255;P(ADDxSLE)=0.251	Application of the quality control procedure showed that 45 ...... Application of the quality control procedure showed that 45 SNPs and 888 subjects were eligible for examination of the main effect of SNP and SNP 6 SLE interactions on the depressive state. In the logistic regression analysis, SLEs (experienced or not experienced) were associated with the depressive state for all SNPs (P=0.0042-4.0E-11). The effect size was relatively large, which indicated that the presence of SLEs has a high impact on developing the depressive state. Three SNPs showed significant associations as main effects on the depressive state ( full results are shown in S3 Table). The top finding was observed at rs7296288, which was selected on the basis of the BD GWAS results. More...

rs1360780 related genes (count: 0)