MK4MDD

Gene Report

Basic Information
Approved Symbol FKBP5
Approved Name FK506 binding protein 5
Previous Name "FK506-binding protein 5"
Symbol Alias FKBP51, FKBP54, PPIase, P54, Ptg-10
Location 6p21.31
Position chr6:35696285-35696360 (-)
External Links Entrez Gene: 2289
Ensembl: ENSG00000096060
UCSC: uc003okx.2
HGNC ID: 3721
No. of Studies (Positive/Negative) 3(3/0) Help
Type Literature-origin

Positive relationships between FKBP5 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
FKBP5 Zobel, 2010 patients and normal controls For three of the five investigated SNPs we were able to show...... For three of the five investigated SNPs we were able to show association with the diagnosis of depression. More...
FKBP5 Szczepankiewicz, 2014 Patients and nomal controls P-value(CCACTAT)=0.014;P-value(ACATTGT)=0.043 Strong linkage disequilibriumwas observed between seven out ...... Strong linkage disequilibriumwas observed between seven out of eight FKBP5 polymorphisms. Haploviewanalysis defined 1 haplotype block containing all analyzed polymorphisms except rs4713916. We observed that haplotypes CCACTAT and ACATTGT were significantly more frequent in the patients with major depressive disorder as compared to the healthy subjects (p=0.014 and p=0.043,respectively), however the significancewas not observed after multiple testing correction (after 10 000 permutations: p=0.078 and p=0.220, respectively)." More...

Positive relationships between FKBP5 and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of FKBP5 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between FKBP5 and MDD (count: 0)
Negative relationships between FKBP5 and other components at different levels (count: 0) Help
FKBP5 related SNPs in MK4MDD (count: 0)
FKBP5 related proteins in MK4MDD (count: 0)
FKBP5 related GO terms (count: 11)
FKBP5 related KEGG pathways (count: 0)
FKBP5 related BioCarta pathways (count: 0)
FKBP5 related Reactome pathways (count: 0)
FKBP5 related interactors from protein-protein interaction data in HPRD (count: 5)