Protein Report

Basic Information

Protein Name	5-hydroxytryptamine receptor 1A
UniPortKB	P08908
No. of Studies (Positive/Negative)	14 (14/0)
Type	Literature-origin

Positive relationship between 5-hydroxytryptamine receptor 1A and MDD (count: 12)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
5HT1A receptor (serotonin-1A receptor)	Drevets, 1999	patients and normal controls	P-value<0.025	The mean 5HT1A receptor BP was reduced 41.5% in the raphe (p...... The mean 5HT1A receptor BP was reduced 41.5% in the raphe (p < .02) and 26.8% in the mesiotemporal cortex (p < .025) in the depressives relative to the controls. More...
5-HT1A receptor	Hsiung, 2003	patients and normal controls		Measurements of [35S]GTPgammaS binding to Galphai/o in the o...... Measurements of [35S]GTPgammaS binding to Galphai/o in the occipital cortex of suicide victims and matched controls revealed a blunted response in suicide subjects and a decrease in the coupling of 5-HT1A receptor to adenylyl cyclase. More...
5-HT(1A) receptor	Meltzer, 2004	patients and normal controls	P-value = 0.0016	We used [11C]WAY 100635 and positron emission tomography (PE...... We used [11C]WAY 100635 and positron emission tomography (PET) to test our hypothesis that 5-HT(1A) receptor binding, We observed significantly diminished [11C]WAY 100635 binding in the DRN (dorsal raphe nucleus) in depressed (BP = 2.31+/-0.90) relative to control (BP = 3.69+/-1.56) subjects (p = 0.0016). More...
5-HT(1A)	Parsey, 2006	patients and normal controls	P-value=0.008	Post hoc testing reveals higher BP (5-HT(1A) binding potenti...... Post hoc testing reveals higher BP (5-HT(1A) binding potential) in AN (antidepressant naive) compared to controls (p = .008) and to AE (antidepressant exposure, p = .007). More...
serotonin 1A (5-HT1A)	Parsey, 2006	patients and normal controls		Despite equivalent treatment, nonremitters have higher pretr...... Despite equivalent treatment, nonremitters have higher pretreatment cortical BP and the GG genotype is over-represented compared with remitters. Higher 5-HT1A BP, perhaps due to greater gene expression, may predict antidepressant medication nonremission. More...
5-HT(1A) receptor	Hasler, 2007	patients only		Comorbid MDD was associated with a significantly more pronou...... Comorbid MDD was associated with a significantly more pronounced reduction in 5-HT(1A) receptor binding in TLE ( temporal lobe epilepsy) patients. Reductions in 5-HT(1A) receptor binding might help elucidate the neurobiological mechanisms underlying the TLE-MDD comorbidity. More...
5-HT1A receptor	Hirvonen, 2008	patients and normal controls		Compared with healthy controls, the BP of [carbonyl-11C]WAY-...... Compared with healthy controls, the BP of [carbonyl-11C]WAY-100635 was reduced in patients with MDD in most brain regions, ranging from -9% to -25%. This study demonstrated a widespread reduction in the availability of serotonin 5-HT1A receptors in a relatively large sample of drug-naive primary-care patients with MDD, suggesting the involvement of this receptor subtype in the pathophysiology of the illness. More...
5-HT1A receptor	Szewczyk, 2009	patients and normal controls	P-value=0.03	5-HT1A receptor protein level was significantly reduced in t...... 5-HT1A receptor protein level was significantly reduced in the prefrontal cortex of female depressed subjects (46%, p=0.03) and unchanged in male depressed subjects compared to gender-matched control subjects. More...
Serotonin-1A	Stockmeier, 2009	patients and normal controls		Antagonist of Serotonin-1A binding was significantly decreas...... Antagonist of Serotonin-1A binding was significantly decreased in outer layers of orbitofrontal cortex in MDD. More...
5-HT(1A) receptor	Miller, 2009	patients and normal controls		Remitted depressed subjects had higher 5-HT(1A) BP(F) compar...... Remitted depressed subjects had higher 5-HT(1A) BP(F) compared with healthy controls. Elevated 5-HT(1A) BP(F) level among subjects with remitted MDD appears to be a trait abnormality in MDD, which may underlie recurrent MDEs. More...
5-HT(1a) receptor	Li, 2010	patients and normal controls		We found that the level of 5-HT was decreased in peripheral ...... We found that the level of 5-HT was decreased in peripheral serum, and the expression of 5-HT(1a) receptor was also decreased in peripheral lymphocytes of major depression patients More...
Serotonin 1A receptors (5-HT(1A))	Parsey, 2010	patients and normal controls	P-value =0 .0001	5-HT(1A) binding potential (BP(F)) was higher in the NRM (no...... 5-HT(1A) binding potential (BP(F)) was higher in the NRM (not recently medicated MDD subjects) compared with control subjects (p = .0001). More...

Positive relationships between 5-hydroxytryptamine receptor 1A and other components at different levels (count: 9)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Related Components
Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
serotonin 1A (5-HT1A)		HTR1A(5-HT1A)	gene	Parsey, 2006	patients and normal controls		Despite equivalent treatment, nonremitters have higher pretr...... Despite equivalent treatment, nonremitters have higher pretreatment cortical BP and the GG genotype is over-represented compared with remitters. Higher 5-HT1A BP, perhaps due to greater gene expression, may predict antidepressant medication nonremission. More...
Serotonin 1A (5-HT(1A)) receptor		Fluoxetine(Fluoxetine)	molecule	Cornelisse, 2007	animal model		selective serotonin reuptake inhibitors selective serotonin reuptake inhibitors
5HT1A receptor (serotonin-1A receptor)		mesiotemporal cortex(mesiotemporal cortex)	brain morphology and function	Drevets, 1999	patients and normal controls	P-value<0.025	The mean 5HT1A receptor BP was reduced 26.8% in the mesiotem...... The mean 5HT1A receptor BP was reduced 26.8% in the mesiotemporal cortex (p < .025) in the depressives relative to the controls. More...
5HT1A receptor (serotonin-1A receptor)		Occipital Lobe(occipital cortex)	brain morphology and function	Drevets, 1999	patients and normal controls		The mean 5HT1A receptor BP was reduced in the occipital cort...... The mean 5HT1A receptor BP was reduced in the occipital cortex in the depressives relative to the controls. More...
5HT1A receptor (serotonin-1A receptor)		Postcentral gyrus(postcentral gyrus)	brain morphology and function	Drevets, 1999	patients and normal controls		The mean 5HT1A receptor BP was reduced in the postcentral gy...... The mean 5HT1A receptor BP was reduced in the postcentral gyrus in the depressives relative to the controls. More...
5HT1A receptor (serotonin-1A receptor)		Raphe(raphe)	brain morphology and function	Drevets, 1999	patients and normal controls	P-value<0.025	The mean 5HT1A receptor BP was reduced 41.5% in the raphe (p...... The mean 5HT1A receptor BP was reduced 41.5% in the raphe (p < .02) in the depressives relative to the controls. More...
5-HT1A receptor		Suicide(suicide)	symptoms	Hsiung, 2003	patients and normal controls		Measurements of [35S]GTPgammaS binding to Galphai/o in the o...... Measurements of [35S]GTPgammaS binding to Galphai/o in the occipital cortex of suicide victims and matched controls revealed a blunted response in suicide subjects and a decrease in the coupling of 5-HT1A receptor to adenylyl cyclase. More...
5-HT(1A) receptor		Depressed mood(depression)	symptoms	Meltzer, 2004	patients and normal controls	r = 0.60, P-value = 0.014	the DRN(dorsal raphe nucleus) BP(5-HT(1A) receptor binding )...... the DRN(dorsal raphe nucleus) BP(5-HT(1A) receptor binding ) was correlated with pretreatment Hamilton Depression Rating Scores (r = 0.60, p = 0.014) in the depressed cohort. More...
Serotonin 1A (5-HT(1A)) receptor		Stress(stress)	environment	Wang SH, 2009	animal model		On the 19th and 28th days after initiating CMS, PSD animals ...... On the 19th and 28th days after initiating CMS, PSD animals displaying a behavioral index of depression (anhedonia) have significantly decreased protein expression of 5-HT(1A) receptors and mRNA level in DG relative to ischemic stroke animals at each timepoint, respectively More...

Positive relationship network of 5-hydroxytryptamine receptor 1A in MK4MDD

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1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between 5-hydroxytryptamine receptor 1A and MDD (count: 0)

Negative relationships between 5-hydroxytryptamine receptor 1A and other components at different levels (count: 0)

Related Gene Info

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	Literature-origin; SNP mapped; Protein mapped	13 (11/2)