MK4MDD

Protein Report

Basic Information
Protein Name 5-hydroxytryptamine receptor 1A
UniPortKB P08908
No. of Studies (Positive/Negative) 14 (14/0) Help
Type Literature-origin
Positive relationship between 5-hydroxytryptamine receptor 1A and MDD (count: 12)
Name in Literature Reference Research Type Statistical Result Relation Description Help
5HT1A receptor (serotonin-1A receptor) Drevets, 1999 patients and normal controls P-value<0.025 The mean 5HT1A receptor BP was reduced 41.5% in the raphe (p...... The mean 5HT1A receptor BP was reduced 41.5% in the raphe (p < .02) and 26.8% in the mesiotemporal cortex (p < .025) in the depressives relative to the controls. More...
5-HT1A receptor Hsiung, 2003 patients and normal controls Measurements of [35S]GTPgammaS binding to Galphai/o in the o...... Measurements of [35S]GTPgammaS binding to Galphai/o in the occipital cortex of suicide victims and matched controls revealed a blunted response in suicide subjects and a decrease in the coupling of 5-HT1A receptor to adenylyl cyclase. More...
5-HT(1A) receptor Meltzer, 2004 patients and normal controls P-value = 0.0016 We used [11C]WAY 100635 and positron emission tomography (PE...... We used [11C]WAY 100635 and positron emission tomography (PET) to test our hypothesis that 5-HT(1A) receptor binding, We observed significantly diminished [11C]WAY 100635 binding in the DRN (dorsal raphe nucleus) in depressed (BP = 2.31+/-0.90) relative to control (BP = 3.69+/-1.56) subjects (p = 0.0016). More...
5-HT(1A) Parsey, 2006 patients and normal controls P-value=0.008 Post hoc testing reveals higher BP (5-HT(1A) binding potenti...... Post hoc testing reveals higher BP (5-HT(1A) binding potential) in AN (antidepressant naive) compared to controls (p = .008) and to AE (antidepressant exposure, p = .007). More...
serotonin 1A (5-HT1A) Parsey, 2006 patients and normal controls Despite equivalent treatment, nonremitters have higher pretr...... Despite equivalent treatment, nonremitters have higher pretreatment cortical BP and the GG genotype is over-represented compared with remitters. Higher 5-HT1A BP, perhaps due to greater gene expression, may predict antidepressant medication nonremission. More...
5-HT(1A) receptor Hasler, 2007 patients only Comorbid MDD was associated with a significantly more pronou...... Comorbid MDD was associated with a significantly more pronounced reduction in 5-HT(1A) receptor binding in TLE ( temporal lobe epilepsy) patients. Reductions in 5-HT(1A) receptor binding might help elucidate the neurobiological mechanisms underlying the TLE-MDD comorbidity. More...
5-HT1A receptor Hirvonen, 2008 patients and normal controls Compared with healthy controls, the BP of [carbonyl-11C]WAY-...... Compared with healthy controls, the BP of [carbonyl-11C]WAY-100635 was reduced in patients with MDD in most brain regions, ranging from -9% to -25%. This study demonstrated a widespread reduction in the availability of serotonin 5-HT1A receptors in a relatively large sample of drug-naive primary-care patients with MDD, suggesting the involvement of this receptor subtype in the pathophysiology of the illness. More...
5-HT1A receptor Szewczyk, 2009 patients and normal controls P-value=0.03 5-HT1A receptor protein level was significantly reduced in t...... 5-HT1A receptor protein level was significantly reduced in the prefrontal cortex of female depressed subjects (46%, p=0.03) and unchanged in male depressed subjects compared to gender-matched control subjects. More...
Serotonin-1A Stockmeier, 2009 patients and normal controls Antagonist of Serotonin-1A binding was significantly decreas...... Antagonist of Serotonin-1A binding was significantly decreased in outer layers of orbitofrontal cortex in MDD. More...
5-HT(1A) receptor Miller, 2009 patients and normal controls Remitted depressed subjects had higher 5-HT(1A) BP(F) compar...... Remitted depressed subjects had higher 5-HT(1A) BP(F) compared with healthy controls. Elevated 5-HT(1A) BP(F) level among subjects with remitted MDD appears to be a trait abnormality in MDD, which may underlie recurrent MDEs. More...
5-HT(1a) receptor Li, 2010 patients and normal controls We found that the level of 5-HT was decreased in peripheral ...... We found that the level of 5-HT was decreased in peripheral serum, and the expression of 5-HT(1a) receptor was also decreased in peripheral lymphocytes of major depression patients More...
Serotonin 1A receptors (5-HT(1A)) Parsey, 2010 patients and normal controls P-value =0 .0001 5-HT(1A) binding potential (BP(F)) was higher in the NRM (no...... 5-HT(1A) binding potential (BP(F)) was higher in the NRM (not recently medicated MDD subjects) compared with control subjects (p = .0001). More...

Positive relationships between 5-hydroxytryptamine receptor 1A and other components at different levels (count: 9) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Positive relationship network of 5-hydroxytryptamine receptor 1A in MK4MDD
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1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between 5-hydroxytryptamine receptor 1A and MDD (count: 0)
Negative relationships between 5-hydroxytryptamine receptor 1A and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Literature-origin; Protein mapped 15 (11/4)